Prognostic nutritional index and its dynamics after curative treatment are independent prognostic factors on survival in non-metastatic nasopharyngeal carcinoma

Küçükarda, Ahmet; Erdoğan, Bülent; Gökyer, Ali; Sayın, Sezin; Gökmen, İvo; Özcan, Erkan; Hacıoğlu, Muhammet Bekir; Uzunoğlu, Sernaz; Çiçin, İrfan

doi:10.1007/s00520-021-06627-6

Cited by 17 publications

(17 citation statements)

References 18 publications

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“…PNI was developed to assess the preoperative nutritional immune status and postoperative complications in surgical patients and has since been demonstrated to be a reliable prognostic factor for numerous malignancies, such as gastric cancer [ 16 ], intrahepatic cholangiocarcinoma [ 29 ], esophageal cancer [ 30 ], and nasopharyngeal carcinoma [ 31 ]. In the field of sepsis, Wu et al reported that after adjusting for confounding variables, PNI was asserted to be an independent prognostic factor for all-cause mortality at 30 days [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Value of Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio in Prediction of the Development of Sepsis-Induced Kidney Injury

et al. 2022

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Background. Sepsis-related acute kidney injury (S-AKI) is a frequent complication of hospitalized patients and is linked to increased morbidity and mortality. Early prediction and detection remain conducive to optimizing treatment strategies and limiting further insults. This study was aimed at evaluating the potential predictive value of the combined prognostic nutrition index (PNI) and neutrophil-to-lymphocyte ratio (NLR) to predict the risk of AKI in septic patients. Methods. In this retrospective study, 1238 adult patients with sepsis who were admitted to the First Affiliated Hospital of Xi’an Jiaotong University from January 2015 to June 2021 were enrolled. Patients were divided into two groups: the non-AKI group ( n = 731 ) and the S-AKI group ( n = 507 ). Univariate and multivariate logistic regression analyses were performed to screen the independent predictive factors of S-AKI. A receiver operating characteristic (ROC) curve was used to evaluate the predictive value of PNI and NLR. Results. Multivariate logistic regression analysis indicated that age, chronic liver disease, cardiovascular disease, respiratory rate (RR), white blood cells (WBC), blood urea nitrogen (BUN), creatinine (CRE), international normalized ratio (INR), neutrophil-to-lymphocyte ratio (NLR), and prognostic nutrition index (PNI) were independent prognostic factors of S-AKI. In the three models, the adjusted OR of PNI for S-AKI was 0.802 (0.776-0.829), 0.801 (0.775-0.829), and 0.717 (0.666-0.772), while that of NLR was 1.094 (1.078-1.111), 1.097 (1.080-1.114), and 1.044 (1.016-1.072), respectively. In addition, the area under the ROC curve of the PNI plus NLR group was significantly greater than that of the CRE plus BUN group (0.801, 95% CI: 0.775-0.827 vs. 0.750, 95% CI: 0.722-0.778, respectively; P < 0.001 ). Conclusions. PNI and NLR have been identified as readily available and independent predictors in septic patients with S-AKI. PNI, in combination with NLR, is of vital significance for early warning and efficient intervention of S-AKI and is superior to combined BUN and CRE.

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Section: Discussionmentioning

confidence: 99%

Clinical Value of Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio in Prediction of the Development of Sepsis-Induced Kidney Injury

et al. 2022

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“…Küçükarda 2022 [55] 143 presenting stage III, IVA, and IVB pharyngeal cancers who were treated with concurrent chemoradiotherapy PNI Patients with ↓ PNI had higher likelihoods of grade 3/4 hematological toxicities, sepsis and toxic death. Patients with ↓ PNI were less probable to tolerate concurrent chemoradiotherapy, even when they treated with a considerably lower dosage of cisplatin, showing a decreased completion rate of planned radiotherapy, or a longer overall radiotherapy treatment time.…”

Section: Pharyngeal Cancermentioning

confidence: 99%

May Nutritional Status Positively Affect Disease Progression and Prognosis in Patients with Oesophageal and Pharyngeal Cancers? A Scoping Review of the Current Clinical Studies

Psara¹,

Papadopoulou²,

Tryfonos³

et al. 2023

Preprint

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Background: Malnutrition in oesophageal and pharyngeal cancer patients constitutes a common and serious concern, which significantly reduces patients’ prognosis. Cancers of the oesophagus and the pharynx can considerably impair feeding in patients, resulting in severe undernutrition. This is a scoping review which aims to critically summarize and scrutinize the current clinical evidence on the use and prognostic role of diverse nutritional assessment tools on the prognosis of patients with oesophageal and pharyngeal cancers. Methods: PubMed, Scopus, Web of Science and Google Scholar databases were comprehensively explored utilizing relative keywords to detect clinical studies that investigate whether nutritional status may affect disease prognosis. Results: Several assessment tools have evaluated and highlighted the prognostic role of nutritional status on patients’ survival and disease complications in both oesophageal and pharyngeal cancers. Regarding oesophageal cancer, CONUT, PNI, PG-SGA and NRS-2002 are more commonly used, while albumin is also frequently evaluated. Regarding pharyngeal cancers, fewer studies are currently available. PNI has been evaluated and its significance as a factor for shorter overall survival, distant metastasis-free survival, progression-free survival, and locoregional recurrence-free has been highlighted. Comprehensive Nutritional Index has also been evaluated with positive results, as well as NRS 2002, GPS, and body weight status. However, there is currently a lack of studies with adequate female patients. There is also a significant lack of well-designed prospective studies with well-organized methodology. Conclusion: Nutritional status may significantly affect disease progression and patients’ survival, highlighting the importance of a good nutritional status in patients with oesophageal and pharyngeal cancers. Further large-scaled and well-designed prospective clinical studies are strongly recommended to verify the potential beneficial effects of nutritional status in patients with oesophageal and pharyngeal cancers.

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“…The prognostic nutritional index (PNI), which is based on the total lymphocyte count and serum albumin concentration in the patient's peripheral blood, is easy to obtain 9,10 . Published studies have shown PNI to be a prognostic marker for digestive cancers 11,12 . For example, Pinato et al 13 and Wang et al 14 found that a low PNI was an independent predictor of poor overall survival (OS) in patients with HCC.…”

Section: Introductionmentioning

confidence: 99%

The prognostic nutritional index predicts prognosis after liver resection in elderly patients with early-stage hepatocellular carcinoma

et al. 2023

Preprint

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Aims We aimed to determine the value of the preoperative prognostic nutritional index (PNI) and establish new nomograms to predict recurrence-free and overall survival (RFS and OS) in elderly patients with early-stage hepatocellular carcinoma (HCC). Methods Elderly patients (≥ 60 years of age) with very early-stage HCC (CNLC IA-IIA) after curative surgical resection were identified. PNI was calculated by [10 × serum albumin level (gr/dL)] + [0.005 × total lymphocyte count (per mm3)]. Univariate and multivariate Cox analysis was used to screen the variables and construct the nomogram model. ROC and calibration curves were used for model evaluation. Results The PNI-high was defined as ≥ 49.5 and ≥ 49.05 for RFS and OS, respectively. The 5-year-RFS rate was 34.1% in the PNI-low group versus 57.4% in the PNI-high group (P = 0.014). The 5-year OS rate in the PNI-low group was significantly lower than that in the PNI-high groups (68.2% vs. 84.4%, P = 0.033). The nomogram prediction models for patients’ RFS and OS were built by incorporating the same three independent survival predictors, including PNI-low, tumor presence of vascular invasion, and low differentiation. These two prediction models demonstrated good calibration and discrimination, with all C‑indexes greater than 0.72. The calibration plots basically coincide with the diagonal, indicating that the observed RFS and OS were close to the predicted outcomes. Conclusions The PNI-low, tumor presence of vascular invasion, and low differentiation can be adopted as a decision aid to predict the long-term RFS and OS for elderly patients with resected HCC.

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Prognostic nutritional index and its dynamics after curative treatment are independent prognostic factors on survival in non-metastatic nasopharyngeal carcinoma

Cited by 17 publications

References 18 publications

Clinical Value of Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio in Prediction of the Development of Sepsis-Induced Kidney Injury

Clinical Value of Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio in Prediction of the Development of Sepsis-Induced Kidney Injury

May Nutritional Status Positively Affect Disease Progression and Prognosis in Patients with Oesophageal and Pharyngeal Cancers? A Scoping Review of the Current Clinical Studies

The prognostic nutritional index predicts prognosis after liver resection in elderly patients with early-stage hepatocellular carcinoma

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