Prognostic model for survival based on readily available pretreatment factors in patients with advanced pancreatic cancer receiving palliative chemotherapy

Abstract

This simple prognostic model could help clinicians to estimate survival in patients with APC who receive palliative chemotherapy.

Preoperative platelet lymphocyte ratio as independent predictors of prognosis in pancreatic cancer: A systematic review and meta-analysis

“…Recently, the preoperative platelet to lymphocyte ratio (PLR), which also reflects the degree of systemic inflammation, has been found to be linked to prognosis in patients with PC [7–9]. However, some studies failed to find correlation between PLR and prognosis of PC [10–12]. We therefore conducted a meta-analysis to assess the prognostic effect of preoperative PLR in PC.…”

The neutrophil-to-lymphocyte ratio (NLR) predicts adrenocortical carcinoma and is correlated with the prognosis

“…Previous reports have shown that an NLR > 5.0 indicates a poor prognosis in pancreas cancer and liver metastatic rectal cancer [15, 16]. Our previous study showed that an NLR > 2.4 was associated with a high risk of prostate cancer in patients with a PSA of 4–10 ng/mL [17].…”

Validation and application of a prognostic model for patients with advanced pancreatic cancer receiving palliative chemotherapy

“…In line with the GS model, the current study helped identify performance status, tumor stage, albumin, and NLR as independent prognostic factors that predict survival outcome. Several prognostic models have been developed for survival prediction among APC patients receiving first‐line palliative chemotherapy . Apart from patient factors (age, sex, performance status, weight loss), laboratory variables (albumin, white cell count, NLR, tumor markers) and tumor characteristics (stage, tumor size, metastatic organ, ascites) have all been reported to be independent prognosticators in different prognostic models .…”

“…Table summarizes and compares 13 published prognostic models for the prediction of the survival outcome of PC patients receiving palliative chemotherapy from a literature review . Only one of the models was designed prospectively ; the others were retrospective studies.…”

“…Only one of the models was designed prospectively ; the others were retrospective studies. Of the 13 prognostic models, some were used for the prediction of survival outcome specifically for gemcitabine‐based treatment, while the other models consisted a broad spectrum of chemotherapeutic regimens . The performance reflected by C‐index ranged from 0.66 to 0.80 among these prognostic models.…”