Prognostic Indicators in 35 Patients with Extramammary Paget's Disease

Abstract

The presence of a nodule on the primary lesion, clinically palpable lymph nodes, the level of tumor invasion, and lymph node metastases were found to be significant prognostic factors in the 35 EMPD cases at our institution.

The Role of Radiotherapy in Extramammary Paget Disease: A Systematic Review

“…8Y25 Doses ranged from 30 to 80.2 Gy delivered in 3 to 43 fractions by means of photons or electrons. A sporadic use of concomitant chemoradiation therapy to treat the EMPD and the concurrent underlying anal cancer was reported by Brown et al 12 Radiotherapy was administered as postoperative adjuvant treatment in 9 articles accounting for 63 (32.3%) patients 9,13,15,17,19,20,22,23,26 with doses ranging between 32 and 64.8 Gy in 20 to 30 fractions delivered by means of photons or electrons.…”

Extramammary Paget′s disease: Analysis of 17 Chinese cases

“…Poor prognostic factors include dermal invasion or metastasis via the lymphatic system. [7,29] Lymph node metastasis in most cases involves inguinal, peri-rectal, retroperitoneal, iliac, and para-aortic lymph nodes. Distant metastasis involves predominantly the liver, bone, lung, and suprarenal glands.…”

Cutaneous Malignancies of the Perineum

“…12,[29][30][31] The role of sentinel lymph node biopsy (SLNB) in EMPD remains unclear; however, it should be considered in cases with invasion (especially with invasion to the reticular dermis) or in cases with palpable lymphadenopathy.…”

“…12,31 Outcomes for in situ EMPD are good, whereas there is a poor prognosis in patients with lymph node involvement and/or distant metastasis. 12 Patients require long-term dermatologic assessments given the potential for EMPD to recur locally.…”