Prognostic Importance of Bone Marrow Uptake on Baseline <sup>18</sup>F-FDG Positron Emission Tomography in Diffuse Large B Cell Lymphoma

Soydal, Çiğdem; Köksoy, Elif Berna; Yaşar, Arzu; Turgal, Ebru; Erdoğan, Beyza Doğanay; Akbulut, Hakan; Küçük, Ömer

doi:10.1089/cbr.2016.2132

Cited by 7 publications

(7 citation statements)

References 18 publications

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“…The finding of dPET+ of BM is not rare in DLBCL. In some studies, this kind of BM pattern was interpreted negative for BMI 2 , while some other researchers considered it as positive 11 , 19 , 20 . The disagreement on the interpretation made it difficult to accurately assess the value of dPET+ in DLBCL.…”

Section: Discussionmentioning

confidence: 99%

“…The prognostic value of BMI based on FDG PET/CT is still not demonstrated clearly. Some studies indicated the excellent prognostic value of PET-BMI in DLBCL patients 2 , 11 , 13 , 22 , while some studies drew the opposite conclusion 14 , 19 , 20 . In their studies, the diffuse BM pattern was interpreted differently, thus more or less leading to different conclusions.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Value of Bone Marrow FDG Uptake Pattern of PET/CT in Newly Diagnosed Diffuse Large B-cell Lymphoma

et al. 2018

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Purpose: The value of 18F-fluorodeoxyglucose positron emission tomography /computed tomography (18F-FDG PET/CT) in assessing bone marrow involvement (BMI) of lymphoma remains controversial. The present study aims to evaluate the prognostic meaning of bone marrow FDG uptake pattern in PET/CT of newly diagnosed diffuse large B-cell lymphoma (DLBCL) patients.Materials and Methods: 193 newly diagnosed DLBCL patients were retrospectively analyzed. All patients received 6-8 cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). The type of BM FDG uptake pattern was recorded by two blinded reviewers independently. The relationship between clinicopathologic features and BM patterns was analyzed. The prognostic value of different BM patterns was evaluated by Log-rank test and Cox-regression analysis.Results: Out of 193 patients, 28 (15%) patients had focal BM FDG uptake higher than liver (fPET+), 18 (9%) patients showed diffuse BM uptake higher than liver (dPET+) and 147 (76%) patients had normal BM uptake (lower than liver) (nPET). BMB positive was found in 35.7% (10/28) of fPET+ patients, in 16.7% (3/18) of dPET+ patients and in 0.7% (1/147) of nPET patients. Diffuse BM pattern was associated with lower hemoglobin level and a trend of higher erythrocyte sedimentation rate (ESR). dPET+ patients had similar 3y-progression-free survival (3y-PFS) and 3y-overall survival (3y-OS) compared with nPET patients (80.5% vs 81.5%, p=0.701; 94.1% vs 90.6%, p=0.809, respectively), while fPET+ patients had worse 3y-PFS and 3y-OS compared with fPET- patients (32.7% vs 81.4%, p<0.001; 69.4% vs 90.9%, p=0.003, respectively). Multivariate analysis showed fPET+ (HR=2.270, p=0.025) and stage III/IV (HR=4.909, p=0.026) were independent predictors for PFS, but no factors were independently predictive for OS.Conclusion: PET/CT-directed BM patterns are meaningful in predicting prognosis of newly diagnosed DLBCL patients. Focal BM pattern is an independent predictor for PFS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Bone Marrow FDG Uptake Pattern of PET/CT in Newly Diagnosed Diffuse Large B-cell Lymphoma

et al. 2018

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“…Molecular imaging provides early-response assessment 208 , chemotherapy monitoring 209 , as well as prognostic insight 210 ; for these purposes, to date, no agent has rivalled the importance and ubiquity of FDG.…”

Section: Imaging and Chemotherapymentioning

confidence: 99%

Multiplexed imaging for diagnosis and therapy

et al. 2017

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Complex molecular and metabolic phenotypes depict cancers as a constellation of different diseases with common themes. Precision imaging of such phenotypes requires flexible and tuneable modalities capable of identifying phenotypic fingerprints by using a restricted number of parameters whilst ensuring sensitivity to dynamic biological regulation. Common phenotypes can be detected by in vivo imaging technologies, and effectively define the emerging standards for disease classification and patient stratification in radiology. However, for the imaging data to accurately represent a complex fingerprint, the individual imaging parameters need to be measured and analysed in relation to their wider spatial and molecular context. In this respect, targeted palettes of molecular imaging probes facilitate the detection of heterogeneity in oncogene-driven alterations and their response to treatment, and lead to the expansion of rational-design elements for the combination of imaging experiments. In this Review, we evaluate criteria for conducting multiplexed imaging, and discuss its opportunities for improving patient diagnosis and the monitoring of therapy.

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“…In recent years, positron emission tomography/computed tomography (PET/CT) has become an effective method in the diagnosis and staging of lymphoma [13]. In recent retrospective studies, the diagnostic and prognostic value of PET/CT to determine BMI remains controversial [14,15].…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Accuracy of Bone Marrow Biopsy Versus PET/CT Scan in Identifying Bone Marrow Involvement in Diffuse Large B Cell Lymphoma Patients at a Cancer Hospital

Asif¹,

Zubair²,

Siddiqui³

et al. 2023

Cureus

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BackgroundIt is of great importance to assess bone marrow involvement (BMI) in diffuse large B cell lymphoma (DLBCL) for staging, prognostic, and therapeutic purposes. The gold standard method used for the identification of bone marrow involvement is bone marrow biopsy (BMB), but it has certain drawbacks. In recent years, positron emission tomography/computed tomography (PET/CT) has become a highly effective method in the diagnosis and staging of lymphoma. ObjectiveThe objective of this study is to estimate the diagnostic accuracy of PET/CT in identifying bone marrow involvement in DLBCL patients in a cancer care hospital in Lahore, using BMB as a reference standard.

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Prognostic Importance of Bone Marrow Uptake on Baseline ¹⁸F-FDG Positron Emission Tomography in Diffuse Large B Cell Lymphoma

Abstract: BM uptake in pretreatment F-FDG PET/CT is an important prognostic factor in DLBCL patients. Moreover, in consideration of high NPV,F-FDG PET/CT could eliminate unnecessary BMB in FDG-negative patients.

Cited by 7 publications

References 18 publications

Prognostic Value of Bone Marrow FDG Uptake Pattern of PET/CT in Newly Diagnosed Diffuse Large B-cell Lymphoma

Prognostic Value of Bone Marrow FDG Uptake Pattern of PET/CT in Newly Diagnosed Diffuse Large B-cell Lymphoma

Multiplexed imaging for diagnosis and therapy

The Diagnostic Accuracy of Bone Marrow Biopsy Versus PET/CT Scan in Identifying Bone Marrow Involvement in Diffuse Large B Cell Lymphoma Patients at a Cancer Hospital

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Prognostic Importance of Bone Marrow Uptake on Baseline 18F-FDG Positron Emission Tomography in Diffuse Large B Cell Lymphoma

Abstract: BM uptake in pretreatment F-FDG PET/CT is an important prognostic factor in DLBCL patients. Moreover, in consideration of high NPV,F-FDG PET/CT could eliminate unnecessary BMB in FDG-negative patients.

Cited by 7 publications

References 18 publications

Prognostic Value of Bone Marrow FDG Uptake Pattern of PET/CT in Newly Diagnosed Diffuse Large B-cell Lymphoma

Prognostic Value of Bone Marrow FDG Uptake Pattern of PET/CT in Newly Diagnosed Diffuse Large B-cell Lymphoma

Multiplexed imaging for diagnosis and therapy

The Diagnostic Accuracy of Bone Marrow Biopsy Versus PET/CT Scan in Identifying Bone Marrow Involvement in Diffuse Large B Cell Lymphoma Patients at a Cancer Hospital

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Prognostic Importance of Bone Marrow Uptake on Baseline ¹⁸F-FDG Positron Emission Tomography in Diffuse Large B Cell Lymphoma