Prognostic Implications of Plaque Characteristics and Stenosis Severity in Patients With Coronary Artery Disease

Lee, Joo Myung; Choi, Gi Hong; Koo, Bon Kwon; Park, Jonghanne; Kim, Jihoon; Hwang, Doyeon; Rhee, Tae Min; Kim, Hyung Yoon; Jung, Hae Won; Kim, Kyung Jin; Kawase, Yoshiaki; Shin, Eun Seok; Doh, Joon Hyung; Chang, Hyuk Jae; Cho, Yun–Kyeong; Yoon, Hyuck Jun; Nam, Chang Wook; Hur, Seung Ho; Wang, Jianan; Chen, Shao‐Liang; Kuramitsu, Shoichi; Tanaka, Nobuhiro; Matsuo, Hitoshi; Akasaka, Takashi

doi:10.1016/j.jacc.2019.02.060

Cited by 126 publications

(95 citation statements)

References 34 publications

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“…Coronary atherosclerotic heart disease (CHD), referred to as coronary heart disease, is mainly due to the occurrence of atherosclerosis in the coronary artery, which makes the lumen narrow or obstructed [ 1 , 2 ]. This heart disease is associated with coronary spasm, leading to myocardial ischemia, hypoxia, or necrosis [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

lncRNA-SNHG14 Promotes Atherosclerosis by Regulating RORα Expression through Sponge miR-19a-3p

Zhu

Liu

Zhao

et al. 2020

Computational and Mathematical Methods in Medicine

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Coronary heart disease (CHD) is the most common cardiovascular disease with high prevalence, disability, and mortality. The balance between proliferation and apoptosis of vascular smooth muscle cells (VSMCs) plays a key role in the initiation of atherosclerosis. In this study, we found a significant decrease in the expression of lncRNA-SNHG14 in atherosclerotic plaque tissues of ApoE-/- mice. Overexpression of lncRNA-SNHG14 can inhibit VSMC proliferation while promoting apoptosis. There is a potential reciprocal regulatory relationship between lncRNASNHG14 and miR-19a-3p, which inhibit each other’s expression in vascular smooth muscle cells. In addition, the luciferase reporter gene analysis results showed that there was a direct interaction between miR-19a-3p and the 3′UTR of RORα. The results of qRT-PCR showed that the level of RORα mRNA was significantly increased in the aortas treated with miR-19a-3p and SNHG14 compared with that treated with miR-19a-3p alone. In conclusion, we demonstrated that lncRNA-SNHG14 regulates the apoptosis/proliferation balance of VSMCs in atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

lncRNA-SNHG14 Promotes Atherosclerosis by Regulating RORα Expression through Sponge miR-19a-3p

Zhu

Liu

Zhao

et al. 2020

Computational and Mathematical Methods in Medicine

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“…Another high-risk vulnerable plaque feature is spotty calcifications, small calcium deposits that can be detected via OCT, IVUS, and CT. For IVUS and OCT, spotty calcification is defined as a calcium length <4 mm and a maximal calcium angle ranging from 22.5 to 90° ( 26 ). For CT, spotty calcifications are typically defined as average density >130 HU, diameter <3 mm in any direction, length of the calcium <1.5× the vessel diameter, and width of the calcification less than two-thirds of the vessel diameter ( 27 ).…”

Section: Plaque Pathobiologymentioning

confidence: 99%

Intravascular Molecular Imaging: Near-Infrared Fluorescence as a New Frontier

Khraishah

Jaffer

2020

Front. Cardiovasc. Med.

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Despite exciting advances in structural intravascular imaging [intravascular ultrasound (IVUS) and optical coherence tomography (OCT)] that have enabled partial assessment of atheroma burden and high-risk features associated with acute coronary syndromes, structural-based imaging modalities alone do not comprehensively phenotype the complex pathobiology of atherosclerosis. Near-infrared fluorescence (NIRF) is an emerging molecular intravascular imaging modality that allows for in vivo visualization of pathobiological and cellular processes at atheroma plaque level, including inflammation, oxidative stress, and abnormal endothelial permeability. Established intravascular NIRF imaging targets include macrophages, cathepsin protease activity, oxidized low-density lipoprotein and abnormal endothelial permeability. Structural and molecular intravascular imaging provide complementary information about plaque microstructure and biology. For this reason, integrated hybrid catheters that combine NIRF-IVUS or NIRF-OCT have been developed to allow co-registration of morphological and molecular processes with a single pullback, as performed for standalone IVUS or OCT. NIRF imaging is approaching application in clinical practice. This will be accelerated by the use of FDA-approved indocyanine green (ICG), which illuminates lipid- and macrophage-rich zones of permeable atheroma. The ability to comprehensively phenotype coronary pathobiology in patients will enable a deeper understanding of plaque pathobiology, improve local and patient-based risk prediction, and usher in a new era of personalized therapy.

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“…It can further identify the independent predictors of adverse cardiac outcomes: plaque burden, location and composition [103,104]. Specific high-risk plaque characteristics which can be identified by CCTA are low-attenuating plaques, positive remodeling and plaque calcifications [105]. Additionally, these high-risk features are independent predictors of acute coronary syndrome in patients presenting with acute chest pain and initial negative electrocardiogram and serum troponin [9].…”

Section: The Implications Of Thementioning

confidence: 99%

“…Lee et al in 2019 provided insight into the implications of simultaneous physiological assessment and quantitative and qualitative plaque evaluation in this patient group [105]. Of note, in the FFR ≤ 0.80 group, similar findings to the previously mentioned studies were noted, whereby the number of high-risk plaque characteristics (HRPC) increased with decreases in FFR and both measures independently predicted adverse outcomes at 5 years (expressed as vessel-oriented composite outcome (VOCO) (a composite of vessel-related ischemia-driven revascularization, vessel-related myocardial infarction, or cardiac death)) [105]. The novel finding was that the presence of ≥3 HRPC was independently associated with the risk of VOCO in the FFR >0.80 group.…”

Section: The Link Between Plaque Characteristics On Ccta and Hemodynamentioning

confidence: 99%

Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics

Clarke

Lau

Zarich

2020

JCM

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The evaluation of coronary lesions has evolved in recent years. Physiologic-guided revascularization (particularly with pressure-derived fractional flow reserve (FFR)) has led to superior outcomes compared to traditional angiographic assessment. A greater importance, therefore, has been placed on the functional significance of an epicardial lesion. Despite the improvements in the limitations of angiography, insights into the relationship between hemodynamic significance and plaque morphology at the lesion level has shown that determining the implications of epicardial lesions is rather complex. Investigators have sought greater understanding by correlating ischemia quantified by FFR with plaque characteristics determined on invasive and non-invasive modalities. We review the background of the use of these diagnostic tools in coronary artery disease and discuss the implications of analyzing physiological stenosis severity and plaque characteristics concurrently.

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Prognostic Implications of Plaque Characteristics and Stenosis Severity in Patients With Coronary Artery Disease

Cited by 126 publications

References 34 publications

lncRNA-SNHG14 Promotes Atherosclerosis by Regulating RORα Expression through Sponge miR-19a-3p

lncRNA-SNHG14 Promotes Atherosclerosis by Regulating RORα Expression through Sponge miR-19a-3p

Intravascular Molecular Imaging: Near-Infrared Fluorescence as a New Frontier

Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics

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