Prognostic implications of node metastatic features in OSCC: A retrospective study on 121 neck dissections

Contaldo, María; Napoli, Antonio Di; Pannone, Giuseppe; Franco, Renato; Ionna, Franco; Feola, Antonia; Rosa, Alfredo De; Santoro, Angela; Sbordone, Carlo; Longo, Francesco; Pasquali, Daniela; Loreto, Carla; Ricciardiello, Filippo; Esposito, Gennaro; D’Angelo, Leonarda; Itro, A; Bufo, Pantaleo; Tombolini, Vincenzo; Serpico, Rosario; Domenico, Marina Di

doi:10.3892/or.2013.2779

Cited by 22 publications

(22 citation statements)

References 29 publications

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“…Oral squamous cell carcinoma (OSCC) at advanced stages can easily be clinically recognized, while the nature and behavior of those at the early or preneoplastic stages, and those with an ambiguous clinical presentation are difficult to foresee based on clinical examination alone. Hence, biopsy and histopathology still represent the diagnostic gold standard in oral oncology . Further complementary noninvasive molecular and imaging techniques could identify the signs of cancerization, thus drastically reducing the diagnostic timing.…”

Section: Discussionmentioning

confidence: 99%

Intraoral confocal microscopy of suspicious oral lesions: a prospective case series

et al. 2019

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Background Oral squamous cell carcinoma (OSCC) accounts for more than 90% of oral epithelial malignancies and often arises from precursor lesions, whose diagnosis is based on biopsy and histopathology. In vivo reflectance confocal microscopy (RCM) images the vital tissues at microscopic resolution, well correlating with conventional histopathology, but it is poorly investigated in oral oncology. The present work aims to describe RCM cytoarchitectural findings in oral mucosae affected by OSCC and its precursors. Materials and Methods A series of clinically suspected oral lesions underwent RCM imaging before conventional biopsy and histopathological assessment in order to identify features suggestive of tumoral changes. Sensitivity (SE), specificity (SP), positive and negative predictive values (PPV and NPV) of RCM compared to histopathology were calculated. Results Totally, 30 sites in 20 patients were considered and clinically classified into 16 “leukoplakia”/“ traumatism”, nine erosive‐ulcerative lesions, three verrucous lesions, and two healthy mucosae, as control. The histopathological “positivity,” due to the presence of various degrees of dysplasia and/or neoplasia, was found in 11 lesions; the RCM “positivity” was referred to nine lesions reporting the RCM detection of polymorphism, multinucleated cells, irregular cellular maturation, altered nuclear/cytoplasm ratio, and abnormal blood vessels. After excluding three verrucous lesions from the RCM analysis, due to the low laser penetration through the hyperkeratotic layers, the results well correlated with histopathology, reporting 1.000 (SE), 0.933 (SP), 0.909 (PPV), and 1.000 (NPV). Conclusion RCM can reveal dysplastic/neoplastic signs occurring in oral lesions, thus supporting their diagnostic pathway.

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Section: Discussionmentioning

confidence: 99%

Intraoral confocal microscopy of suspicious oral lesions: a prospective case series

et al. 2019

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“…They concluded that the destruction of the complex E-cadherin-catenin is a tardive result correlated with tumor infiltration. Some authors have found that the tumors shown a heterogeneous distribution of E-cadherin and that the loss of E-cadherin shows a statistically significant correlation with the degree of oral cancer or with lesions in the advanced stage and nodal metastasis [119, 120]. In contrast, others authors did not show a link between tumor differentiation and E-cadherin expression [121, 122].…”

Section: Epithelial Mesenchymal Transition and Tumorigenesismentioning

confidence: 99%

Signal transduction growth factors: the effective governance of transcription and cellular adhesion in cancer invasion

Domenico

Giordano

2017

Oncotarget

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Giulio Bizzozero classified the tissues concerning their capacity to self-renew during the adult life in labile, stable and permanent tissues. In 1940 Viktor Hamburger and Rita Levi Montalcini exposed the possibility to induce the growth of permanent cells thanks to a specific ligand Nerve Growth Factor (NGF). Stanley Cohen purified a protein the Epidermal Growth Factor (EGF), able to induce epidermis proliferation and to elicit precocious eye disclosure and teeth eruption, establishing the “inverse” relationships between the proliferation and differentiation. These two biological effects induced by EGF were according to EGFR signaling is involved in a large array of cellular functions such as proliferation, survival, adhesion, migration and differentiation. This review is focused on the key role of growth factors signaling and their downstream effectors in physiological and in pathological phenomena, the authors highlight the governance of Growth factors during the EMT in cancer invasion.

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“…OSCC often involves cervical lymph nodes [4], which are associated with up to 50% decrease in survival [5]. The therapeutic management is based, therefore, on the clinically assessed risk of node metastasis of the primary tumor.…”

Section: Introductionmentioning

confidence: 99%

“…The therapeutic management is based, therefore, on the clinically assessed risk of node metastasis of the primary tumor. After clinical TNM evaluation, a radical neck dissection is mandatory for OSCCs showing with clinically positive cervical lymph nodes (cN+), whereas an elective selective procedure is indicated for those with undetectable lymph nodes (cN0) or a risk of regional metastasis greater than 20% [4].…”

Section: Introductionmentioning

confidence: 99%

Oral Cancer Treatment: Still an Indication for Elective Neck Dissection?

Koyama

Matos

Kulcsar

et al. 2018

ORL

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Introduction: Oral squamous cell carcinoma has a high incidence and, although elective neck dissection is recommended, the removed nodes frequently present without metastasis. This surgical approach causes disabilities and increases possible surgical complications. Objective: To evaluate the possibility of a watchful waiting approach in oral cancer. Methods: We compared 78 patients with clinical and pathological node metastases and their counterparts with pathological node metastases but without evident clinical neck disease. Therefore, we provided a theoretical comparison between the patients who had an elective neck dissection and those who waited until a clinically positive node was evident. Results: The prognostic factor rates were similar between the groups. Their regional recurrence and mortality rates had no statistical differences. Conclusion: A watchful waiting policy could be applied to selected oral cancer patients who can undergo a very close follow-up. This option would be more cost-effective and less harmful than elective neck dissection.

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Prognostic implications of node metastatic features in OSCC: A retrospective study on 121 neck dissections

Cited by 22 publications

References 29 publications

Intraoral confocal microscopy of suspicious oral lesions: a prospective case series

Intraoral confocal microscopy of suspicious oral lesions: a prospective case series

Signal transduction growth factors: the effective governance of transcription and cellular adhesion in cancer invasion

Oral Cancer Treatment: Still an Indication for Elective Neck Dissection?

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