Prognostic impact of perineural invasion and lymphovascular invasion in advanced stage oral squamous cell carcinoma

Jardim, Juscelino Freitas; Francisco, Ana Lúcia Noronha; Gondak, Rogério; Damascena, Aline Santos; Kowalski, Luiz Paulo

doi:10.1016/j.ijom.2014.10.006

Cited by 130 publications

(129 citation statements)

References 25 publications

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“…results could be explained with the postoperative irradiation, though we found no evidence for less recurrence after adjuvant treatment in general. Similar to recent reports about the role of histologic risk factors [26], in our study, perineural or lymphovascular invasion was significantly associated with initial positive nodes. The rate of 13.3% of histopathological confirmed lymph node metastases recorded in the present study is below the listed range of 17-54% specifically mentioned for maxillary OSCC in related cohort studies [11,19,22,23,[27][28][29][30].…”

Section: Discussionsupporting

confidence: 91%

Metastatic pattern in squamous cell carcinoma of the hard palate and maxillary alveolar ridge: clinical experience and review of the literature

et al. 2017

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Purpose Oral squamous cell carcinoma of the hard palate and upper alveolar ridge is rare with only few published current data regarding regional metastases after elective neck dissection or adjuvant therapy. Our aim was to investigate the incidence of initial and delayed nodal metastasis and to identify predictive factors. Methods In a retrospective cohort study, we enrolled 48 primarily surgical-treated patients from 2004 to 2014. Results Pathological initial nodal metastasis rate was 13.3% (6/45). Poor histologic grade (p = 0.048), lymphovascular infiltration (p \ 0.001) and perineural infiltration (p = 0.01) correlated with initial nodal metastasis, while advanced T-stage showed no significance (p = 0.07). Regional recurrences occurred in 14.6% of patients (7/48) and tended to emerge less frequently after therapeutic than elective neck dissection. Tumor involvement of the vestibular alveolar mucosa was a prognostic factor for developing regional recurrence (p = 0.034). Overall nodal disease rate was 27.1% (13/48). Disease-free and overall survival rates were at 73 and 93%, respectively. Conclusions The presence of poor histologic characteristics is a high risk for nodal metastasis. In patients with tumors in contact with the upper vestibular fold, the hypothesis of an impact on metastasis needs further validation.

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Section: Discussionsupporting

confidence: 91%

Metastatic pattern in squamous cell carcinoma of the hard palate and maxillary alveolar ridge: clinical experience and review of the literature

et al. 2017

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“…Jardim et al 13 and Kosec et al 14 have both recently showed that the presence of PNS is a negative prognostic factor for patient outcomes. Broadly speaking, patients are treated with either combination surgery and radiotherapy, radiation alone or with palliation.…”

Section: Discussionmentioning

confidence: 99%

3T MRI evaluation of large nerve perineural spread of head and neck cancers

et al. 2015

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Targeted 3T MRI is highly accurate in defining the presence and extent of large nerve PNS in head and neck cancers. However, there is still a tendency to undercall the zonal extent due to microscopic, radiologically occult involvement. Superficial large nerve involvement also remains a difficult area of detection for radiologists and should be included as a 'check area' for review. Further research is required to define the role radiation-induced neuritis plays in the presence of false-positive PNS on MRI.

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“…LVI and the POI have been identified as histological parameters that may predict more aggressive tumour biology in early‐stage oral cavity SCC . Therefore, the ability of pathologists to reproducibly identify LVI and classify the POI is clinically relevant.…”

Section: Discussionmentioning

confidence: 99%

Pattern of invasion and lymphovascular invasion in squamous cell carcinoma of the floor of the mouth: an interobserver variability study

et al. 2016

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Prognostic impact of perineural invasion and lymphovascular invasion in advanced stage oral squamous cell carcinoma

Cited by 130 publications

References 25 publications

Metastatic pattern in squamous cell carcinoma of the hard palate and maxillary alveolar ridge: clinical experience and review of the literature

Metastatic pattern in squamous cell carcinoma of the hard palate and maxillary alveolar ridge: clinical experience and review of the literature

3T MRI evaluation of large nerve perineural spread of head and neck cancers

Pattern of invasion and lymphovascular invasion in squamous cell carcinoma of the floor of the mouth: an interobserver variability study

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