Pattern of invasion and lymphovascular invasion in squamous cell carcinoma of the floor of the mouth: an interobserver variability study

Beggan, Caitlin; Fives, Cassie; O’Leary, Gerard; Sheahan, Patrick; Heffron, Cynthia; Feeley, Linda

doi:10.1111/his.13014

Cited by 16 publications

(16 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the single histopathological features, Sawair et al found moderate Kappa values for keratinisation (0.48) and even worse ones for pattern of invasion 33. Analysis of Kappa values for the pattern of invasion as defined by the Royal College of Pathologists34 resulted in kappa values between 0.43 and 0.58 in a study by Beggan et al ,35 whereas Heerema et al found values between 0.25 and 0.5853 and Chang et al a value of 0.72 36. Interobserver agreement of the HR model was good with κ =0.84 37.…”

Section: Discussionmentioning

confidence: 98%

Novel prognostic histopathological grading system in oral squamous cell carcinoma based on tumour budding and cell nest size shows high interobserver and intraobserver concordance

et al. 2018

View full text Add to dashboard Cite

AimsSquamous cell carcinoma of the oral cavity (OSCC) is a common tumour entity with a variable, partially highly aggressive clinical course. Recently, we proposed a novel (three-tiered) clinically useful grading scheme strongly associated with patient outcome in OSCC, consisting of a sum score of the histomorphological patterns tumour budding and cell nest size which outperforms WHO based grading algorithms currently in use. The aim of our study was to probe for interobserver and intraobserver reliability of this novel grading system.Methods108 OSCC were retrospectively scored according to the proposed grading scheme by three independent pathologists—two experienced head and neck pathologists and one pathologist in training—blinded to each other’s scoring results.ResultsThe Cohen’s Kappa (κ) values for concordance rates between experienced pathologists were κ=0.97 for the overall grade, κ=0.97 for budding activity and κ=0.91 for cell nest size, indicating a strong interobserver reliability of our proposed grading system. Initial interobserver agreement was markedly lower with the pathologist in training (κ=0.55 for overall grade) but improved significantly after a training session (κ=0.87 for overall grade). Intraobserver concordance was high (κ=0.95 for overall grade), indicating a high reproducibility of the algorithm.ConclusionsIn conclusion, our study indicates that OSCC grading based on our proposed novel scheme yields an excellent inter-reader and intrareader agreement, further supporting the suitability of this grading system for routine pathological practice.

show abstract

Section: Discussionmentioning

confidence: 98%

Novel prognostic histopathological grading system in oral squamous cell carcinoma based on tumour budding and cell nest size shows high interobserver and intraobserver concordance

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Agreement was not improved with the use of CD31 (κ = 0.26) or D2‐40 (κ = 0.32). LVSI assessment in squamous carcinoma of the floor of the mouth was performed on H&E slides from 58 cases by three pathologists using their own criteria. This resulted in substantial agreement for LVSI (κ = 0.64), comparable to our findings.…”

Section: Discussionmentioning

confidence: 99%

“…Reproducibility of LVSI assessment has also been studied in the context of other tumours, such as hepatocellular carcinoma (HCC), colorectal cancer and squamous cell carcinoma of the floor of the mouth . In the HCC study, inter‐ and intraobserver reproducibility of six pathologists were analysed.…”

Section: Discussionmentioning

confidence: 99%

Reproducibility of lymphovascular space invasion (LVSI) assessment in endometrial cancer

et al. 2019

View full text Add to dashboard Cite

AimsLymphovascular space invasion (LVSI) in endometrial cancer (EC) is an important prognostic variable impacting on a patient's individual recurrence risk and adjuvant treatment recommendations. Recent work has shown that grading the extent of LVSI further improves its prognostic strength in patients with stage I endometrioid EC. Despite this, there is little information on the reproducibility of LVSI assessment in EC. Therefore, we designed a study to evaluate interobserver agreement in discriminating true LVSI from LVSI mimics (Phase I) and reproducibility of grading extent of LVSI (Phase II).Methods and resultsScanned haematoxylin and eosin (H&E) slides of endometrioid EC (EEC) with a predefined possible LVSI focus were hosted on a website and assessed by a panel of six European gynaecological pathologists. In Phase I, 48 H&E slides were included for LVSI assessment and in Phase II, 42 H&E slides for LVSI grading. Each observer was instructed to apply the criteria for LVSI used in daily practice. The degree of agreement was measured using the two‐way absolute agreement average‐measures intraclass correlation coefficient (ICC). Reproducibility of LVSI assessment (ICC = 0.64, P < 0.001) and LVSI grading (ICC = 0.62, P < 0.001) in EEC was substantial among the observers.ConclusionsGiven the good reproducibility of LVSI, this study further supports the important role of LVSI in decision algorithms for adjuvant treatment.

show abstract

“…In contrast histopathologically superficial cortical erosion is insufficient to classify a patient as having pathological bone involvement (pT4a) as this has not consistently been shown to be of prognostic significance. Instead invasion into the medullary cavity is necessary pathologically to be called positive bone invasion 12, 13. This is a likely contributory factor to the reported low specificity of both CT and MRI in the evaluation of mandibular bone invasion by SCC 6, 16, 17, 18.…”

Section: Discussionmentioning

confidence: 99%

Utility of CT and MRI in assessment of mandibular involvement in oral cavity cancer

Nae

O’Leary

Feeley

et al. 2019

World j. otorhinolaryngol.-head neck surg.

Self Cite

View full text Add to dashboard Cite

Objective Oral cavity squamous cell carcinoma (SCC) may present with early invasion of mandibular bone. Preoperative planning of surgery is essential considering patient's postoperative quality of life. Our purpose was to evaluate the efficacy of computer tomography scan (CT) and magnetic resonance imaging (MRI) in detecting mandibular bone involvement in oral SCC. Methods A retrospective study was conducted on 98 patients with SCC of floor of mouth, lower alveolus and retromolar trigone operated on with curative intent. Preoperative CT and MRI scans were re-reviewed by a consultant radiologist and original histology slides were re-reviewed by 3 pathologists. Results Forty-five patients were included in the final study. Combined CT and MRI had a sensitivity of 100% and a specificity of 72%. Conclusion The results suggest that combined CT and MRI have diagnostic utility in detecting mandibular invasion by oral cancer, but with a significant false positive rate.

show abstract

Pattern of invasion and lymphovascular invasion in squamous cell carcinoma of the floor of the mouth: an interobserver variability study

Abstract: Interobserver agreement in the diagnosis of LVI was substantial. The POI at the 50% and 20% cut-offs is moderately reproducible, and has prognostic value in FOM SCC. Further studies are necessary to establish the optimum quantitative cut-off for the POI.

Cited by 16 publications

References 25 publications

Novel prognostic histopathological grading system in oral squamous cell carcinoma based on tumour budding and cell nest size shows high interobserver and intraobserver concordance

Novel prognostic histopathological grading system in oral squamous cell carcinoma based on tumour budding and cell nest size shows high interobserver and intraobserver concordance

Reproducibility of lymphovascular space invasion (LVSI) assessment in endometrial cancer

Utility of CT and MRI in assessment of mandibular involvement in oral cavity cancer

Contact Info

Product

Resources

About