Prognostic impact of perineural invasion in early stage oral tongue squamous cell carcinoma: Results from a prospective randomized trial

Yang, Xi; Tian, Xuerui; Wu, Kailong; Liu, Wei; Li, Siyi; Zhang, Zhiyuan; Zhang, Chenping

doi:10.1016/j.suronc.2018.02.005

Cited by 48 publications

(75 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7,13,22,26 PNI is considered an exacerbating feature that can worsen the prognosis of patients with surgical close margins, 21,27 and it has been associated with an increased risk of regional recurrence. 18,[28][29][30][31] Conversely, PNTS is not associated with greater risk of regional metastasis, but the locally mediated morbidity can be severe. In cases of advanced uncontrolled PNTS, patients experience debilitating symptoms such as neuropathic pain, numbness or other sensory nerve dysfunction, paralysis, disfigurement, and injury from motor nerve dysfunction.…”

Section: Clinical Significancementioning

confidence: 99%

“…PNI more frequently develops in small, unnamed nerve fibers within the tumor specimen, at rates as high as 42% to 52%. 13,92 The presence of PNI in oral cavity cancer has been associated with worsened survival and regional nodal metastasis, [29][30][31] and the presence of PNI may be a factor warranting a neck dissection. PNI has also been demonstrated to be predictive of distant recurrences, 93 supporting its role as an adverse prognostic feature.…”

Section: Oral Cavity Cancermentioning

confidence: 99%

See 1 more Smart Citation

Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer

Bakst

Glastonbury

Parvathaneni

et al. 2019

International Journal of Radiation Oncology*Biology*Physics

137

View full text Add to dashboard Cite

Section: Clinical Significancementioning

confidence: 99%

Section: Oral Cavity Cancermentioning

confidence: 99%

Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer

Bakst

Glastonbury

Parvathaneni

et al. 2019

International Journal of Radiation Oncology*Biology*Physics

137

View full text Add to dashboard Cite

“…At sites such as the tongue and/or floor of the mouth, PNI was detected in up to 70% of OSCC, whereas cancer of the lower lip has a lower rate of PNI at 5.2% 6 . PNI exhibited by some OSCC has been known as an independent predictor of poor prognosis and an indicator of aggressive behaviour 7‐9 . The presence of PNI is significantly correlated with advanced T and N tumour staging, extranodal extension, poor tumour differentiation, lymphovascular invasion and increased depth of invasion, and therefore, PNI seems to be critical to prognosis in OSCC 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Perineural invasion in oral squamous cell carcinoma: Incidence, prognostic impact and molecular insight

Alkhadar

Macluskey

White

et al. 2020

J Oral Pathology Medicine

View full text Add to dashboard Cite

Background The objective of this study was to characterise the incidence and prognostic correlation of perineural invasion (PNI) in oral squamous cell carcinoma and determine whether nerve growth factor and its receptor tyrosine Kinase A expression could be used as biological markers for PNI. Methods A retrospective review of pathology reports of 430 patients with oral squamous cell carcinoma who were treated from 1992 to 2014 in Tayside, Scotland, was carried out. The expression of nerve growth factor and tyrosine kinase A was assessed with immunohistochemistry in 132 tissue sections of oral squamous cell carcinoma. Results Perineural invasion was identified in 17.4% of oral squamous cell carcinomas. High expression of nerve growth factor and tyrosine kinase A was seen in 84% and 92% of oral squamous cell carcinoma, respectively. Tumours with PNI expressed nerve growth factor and tyrosine kinase A with a greater frequency than tumours without PNI. PNI and high expression of nerve growth factor were significantly associated with pain. PNI was significantly associated with stage IV tumours and poor disease‐specific survival. Conclusions A higher level of expression of nerve growth factor and tyrosine kinase A may predict PNI and therefore may be considered as biological markers for PNI in oral squamous cell carcinoma. PNI and nerve growth factor overexpression may contribute to the pain generation in oral cancer patients. PNI and nerve growth factor expression can predict the aggressiveness and prognosis of oral squamous cell carcinoma patients.

show abstract

“…PNI is a factor that can determine lymph node involvement, recurrence, disease-free and overall survival necessitating appropriate treatment management if susceptibility is detected. Elective neck dissection is prescribed for T1/T2N0 PNI+ patients [15,16]. Additionally, PNI was identified as a prognostic factor in early stage tongue cancer, while LVI was a significant parameter in late stage buccal mucosal cancers [3].…”

Section: Introductionmentioning

confidence: 99%

Molecular prognosticators in clinically and pathologically distinct cohorts of head and neck squamous cell carcinoma—A meta-analysis approach

2019

View full text Add to dashboard Cite

Head and neck squamous cell carcinomas (HNSCC) includes multiple subsites that exhibit differential treatment outcome, which is in turn reflective of tumor stage/histopathology and molecular profile. This study hypothesized that the molecular profile is an accurate prognostic adjunct in patients triaged based on clinico-pathological characteristics. Towards this effect, publically available micro-array datasets (n = 8), were downloaded, classified based on HPV association (n = 83) and site (tongue n = 88; laryngopharynx n = 53; oropharynx n = 51) and re-analyzed (Genespring; v13.1). The significant genes were validated in respective cohorts in The Cancer Genome Atlas (TCGA) for correlation with clinico-pathological parameters/survival. The gene entities (n = 3258) identified from HPV based analysis, when validated in TCGA identified the subset specifically altered in HPV+ HNSCC (n = 63), with three genes showing survival impact (RPP25, NUDCD2, NOVA1). Site-specific meta-analysis identified respective differentials (tongue: 3508, laryngopharynx: 4893, oropharynx: 2386); validation in TCGA revealed markers with high incidence (altered in >10% of patients) in tongue (n = 331), laryngopharynx (n = 701) and oropharynx (n = 404). Assessment of these genes in clinical sub-cohorts of TCGA indicated that early stage tongue (MTFR1, C8ORF33, OTUD6B) and laryngeal cancers (TWISTNB, KLHL13 and UBE2Q1) were defined by distinct prognosticators. Similarly, correlation with perineural/angiolymophatic invasion, identified discrete marker panels with survival impact (tongue: NUDCD1, PRKC1; laryngopharynx: SLC4A1AP, PIK3CA, AP2M1). Alterations in ANO1, NUDCD1, PIK3CA defined survival in tongue cancer patients with nodal metastasis (node+ECS-), while EPS8 is a significant differential in node+ECS-laryngopharyngeal cancers. In oropharynx, wherein HPV is a major etiological factor, distinct prognosticators were identified in HPV+ (ECHDC2, HERC5, GGT6) and HPV-(GRB10, EMILIN1, FNDC1). Meta-analysis in combination with TCGA validation carried out in this study emphasized on the molecular heterogeneity inherent within HNSCC; the feasibility of leveraging this information for

show abstract

Prognostic impact of perineural invasion in early stage oral tongue squamous cell carcinoma: Results from a prospective randomized trial

Cited by 48 publications

References 25 publications

Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer

Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer

Perineural invasion in oral squamous cell carcinoma: Incidence, prognostic impact and molecular insight

Molecular prognosticators in clinically and pathologically distinct cohorts of head and neck squamous cell carcinoma—A meta-analysis approach

Contact Info

Product

Resources

About