Prognostic impact of morphometric nuclear grade of endometrial carcinoma

Salvesen, Helga B.; Iversen, Ole Erik; Akslen, Lars A.

doi:10.1002/(sici)1097-0142(19980901)83:5<956::aid-cncr22>3.3.co;2-f

Cited by 3 publications

(6 citation statements)

References 15 publications

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“…This is in agreement with three former investigations showing that morphometric evaluation of nuclear size has an important prognostic impact (7,12,13) . Another study also showed nuclear perimeter to be the most important morphometric factor in combination with stage and grade (13) . These results are in agreement with the present results in which nuclear perimeter was the only statistically significant morphometric factor in the logistic regression analysis.…”

Section: Discussionsupporting

confidence: 93%

“…The multivariate survival analysis showed that the morphometric nuclear parameters were prognostically superior to subjectively assessed grade. This is in agreement with three former investigations showing that morphometric evaluation of nuclear size has an important prognostic impact (7,12,13) . Another study also showed nuclear perimeter to be the most important morphometric factor in combination with stage and grade (13) .…”

Section: Discussionsupporting

confidence: 91%

“…Both ploidy and myometrial invasion were significantly related to prognosis in the univariate analysis. Both factors lost their prognostic power in the logistic regression model, which is consistent with a previous report (13) . It thus seems that that genomic instability as reflected by flowcytometric DNA measurement is of highest value when FIGO I cancers of the endometrium are studied separately (7,26) .…”

Section: Discussionsupporting

confidence: 90%

“…Quantitative pathologic features derived from techniques such as morphometry, stereology (9) , and DNA image and flow cytometry (10,11) are examples of more objective methods that may be more reproducible than grade. During the past decade morphometric studies have been published showing a strong prognostic impact of nuclear measurement for endometrial cancer (7,8,12,13) . The current work was performed to evaluate the prognostic value of nuclear morphometric data and DNA ploidy in retrospective material gathered from patients with all stages of endometrial carcinoma in northern Norway.…”

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confidence: 99%

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Significance of morphometric, DNA cytometric features, and other prognostic markers on survival of endometrial cancer patients in northern Norway

Ørbo¹,

Rydningen²,

Straume³

et al. 2002

International Journal of Gynecological Cancer

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The objective of this study was to evaluate the prognostic value of nuclear morphometric features and DNA ploidy by flow cytometry next to depth of myometrial invasion and vascular invasion in endometrial cancer of all FIGO stages. A total of 123 women (103 FIGO stage I, eight stage II, and 12 stage III and IV) from northern Norway were studied. The follow-up period was between 7 and 19 years. The median age of patients was 62 years. The primary surgery was performed in the University Hospital of Tromso or in the seven different reference hospitals in the northern part of Norway after an endometrial cancer diagnosis. The histologic, morphometric,flow cytometric and immunohistochemical investigations were based on archival paraffin-embedded material. The information regarding the follow-up data and clinical information were obtained from the medical records. Thirteen (10.6%) patients from the entire group (all stages) but only three (2.7%) of the FIGO stage I and II patients died from locally recurrent or metastatic disease. FIGO substage (P = 0.0006; odds ratio [OR] =16.44, 95% confidence interval [CI] = 3.36-80.45), vascular invasion (P =0.01, OR = 6.42, CI = 1.57-26.34) and nuclear size (P = 0.025, OR = 1.3,CI = 1.05-1.61) were independently correlated with recurrence in a multivariate analysis but histologic grade and DNA ploidy were not. Vascular invasion was poorly reproducible both between and within the same observer, however. In this retrospective study of all stages of endometrial carcinoma with long follow-up periods the primary tumor characteristics nuclear perimeter and FIGO stage were of prognostic significance in addition to the poorly reproducible vessel invasion.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

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Significance of morphometric, DNA cytometric features, and other prognostic markers on survival of endometrial cancer patients in northern Norway

Ørbo¹,

Rydningen²,

Straume³

et al. 2002

International Journal of Gynecological Cancer

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“…Both DNA ploidy and SPF have been investigated extensively, but due to variations in inclusion criteria, different risk groupings, and other methodological problems, the results have been conflicting. Some studies have found a strong prognostic value of DNA ploidy , which has not been found by others . Likewise, SPF has been found to have and not have prognostic value in different studies, and some authors have reported independent prognostic value of both variables in multivariable analysis .…”

Section: Introductionmentioning

confidence: 86%

Cell proliferation, measured as flow cytometric S‐phase fraction, is a strong prognostic indicator in FIGO stage I endometrioid endometrial carcinoma: a population‐based study

Green

Engblom

Baldetorp

et al. 2015

Acta Obstet Gynecol Scand

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Cell proliferation, measured as flow cytometric S-phase fraction, is a strong prognostic indicator in FIGO stage I endometrioid endometrial carcinoma: a population-based study.Green, Rasmus W; Engblom, Sanna; Baldetorp, Bo; Werner Hartman, Linda; Måsbäck, Anna; Bjurberg, Maria Citation for published version (APA): Green, R. W., Engblom, S., Baldetorp, B., Werner Hartman, L., Måsbäck, A., & Bjurberg, M. (2015). Cell proliferation, measured as flow cytometric S-phase fraction, is a strong prognostic indicator in FIGO stage I endometrioid endometrial carcinoma: a population-based study. Acta Obstetricia et Gynecologica Scandinavica, 94(10), 1064-1073. https://doi.org/10.1111/aogs.12704General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Conflicts of interestsNone of the authors have any conflicts of interests to declare.

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Molecular pathogenesis and prognostic factors in endometrial carcinoma

Salvesen

Akslen

2002

APMIS

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Endometrial carcinoma is today among the most common gynecologic malignancies in industrialized countries. In order to improve the treatment and follow-up of these patients, various prognostic factors have been extensively studied. Patient age, stage of disease, histologic type and histologic grade have been shown to influence survival significantly, and the prognostic impact of these traditional clinicopathologic variables is well established. In addition, parity, hormone receptor concentration in the tumor, DNA ploidy and morphometric nuclear grade have all been found to influence prognosis. Information about DNA ploidy has especially been used in the clinical situation to determine individualized treatment. The prognostic significance of markers for tumor cell proliferation, cell cycle regulation (p53, p21 and p16) and angiogenesis is discussed as well as the molecular basis of endometrial carcinoma. In conclusion, several prognostic markers have been identified. It is likely that the information derived from these tumor biomarkers will reduce the need for extensive surgical staging and adjuvant treatment in endometrial carcinoma.

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Prognostic impact of morphometric nuclear grade of endometrial carcinoma

Cited by 3 publications

References 15 publications

Significance of morphometric, DNA cytometric features, and other prognostic markers on survival of endometrial cancer patients in northern Norway

Significance of morphometric, DNA cytometric features, and other prognostic markers on survival of endometrial cancer patients in northern Norway

Cell proliferation, measured as flow cytometric S‐phase fraction, is a strong prognostic indicator in FIGO stage I endometrioid endometrial carcinoma: a population‐based study

Molecular pathogenesis and prognostic factors in endometrial carcinoma

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