Cell proliferation, measured as flow cytometric S‐phase fraction, is a strong prognostic indicator in FIGO stage I endometrioid endometrial carcinoma: a population‐based study

Abstract

Cell proliferation, measured as flow cytometric S-phase fraction, is a strong prognostic indicator in FIGO stage I endometrioid endometrial carcinoma: a population-based study.Green, Rasmus W; Engblom, Sanna; Baldetorp, Bo; Werner Hartman, Linda; Måsbäck, Anna; Bjurberg, Maria Citation for published version (APA): Green, R. W., Engblom, S., Baldetorp, B., Werner Hartman, L., Måsbäck, A., & Bjurberg, M. (2015). Cell proliferation, measured as flow cytometric S-phase fraction, is a strong prognostic indicator in FIGO stage I endometrioid endometrial carcinoma: a population-based study. Acta Obstetricia et Gynecologica Scandinavica, 94(10), 1064-1073. https://doi.org/10.1111/aogs.12704General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Conflicts of interestsNone of the authors have any conflicts of interests to declare.

DNA ploidy status, S-phase fraction, and p53 are not independent prognostic factors for survival in endometrioid endometrial carcinoma FIGO stage I–III

“…When an S-phase fraction cut-off >5.5% was used in an equivalent study, S-phase fraction was associated with worse outcome for endometrial cancer death (HR 2.6, 95% CI 1.5 to 4.4; p=0.001) 19. These reverse results might be explained by the different cut-offs used, different estimations of survival (relative vs overall survival), and by the large amount of missing data in the latter study.…”

“…Other strengths are the large sample size of 1113 women, the limited amount of missing data compared with previous studies,19 and the fact that patients were only lost to follow-up because of emigration. Moreover, histopathology, grade, and p53 staining was audited in a reference demonstration to avoid misclassification, and S-phase fraction and DNA ploidy were analyzed in a single laboratory.…”

“…Studies of S-phase fraction by flow cytometry have shown a prognostic impact in endometrial carcinoma 12. In stage I endometrioid endometrial carcinoma the results are conflicting,18 even though a large recent Swedish study on S-phase fraction showed independent prognostic significance when adjusted for stage, age, and grade 19…”

International Society of Gynecological Pathologists (ISGyP) Endometrial Cancer Project: Guidelines From the Special Techniques and Ancillary Studies Group

“…Similar comments pertain to ploidy analysis. There is some literature on the association of ploidy with prognosis, with promising results 8,9, but there is a lack of definitive studies to determine its true prognostic impact 10.…”

Egenskaper ved kreftcellenes DNA påvirker prognosen

“…I en studie med 1 140 pasienter observerte man signifikant sammenheng mellom DNAploidistatus og prognose i univariate overlevelsesanalyser, mens kun andelen celler i delingsfase hadde uavhengig prognostisk verdi i multivariatanalyser (14).…”