“…CXCR4 and its chemokine ligand CXCL12 are highly expressed in EAC, and the expression is associated with poor prognosis and lymph node metastases [85,90]. High expression of the chemokine receptor CXCR7 and its chemokine ligand CXCL12 in EAC is also associated with poor prognosis [91]. In addition, the chemokines, chemokine receptors, cytokines and interleukins CXCR1, CXCR2, CXCL1, CXCL2, CXCL3, CXCL6, CXCL8, CCL15, CCR4, IL-2, IL-6, IL-7, IL-8, IL-15 and IL-18 are significantly higher expressed in HGD/EAC compared to LGD/BE [92].…”