Atypical chemokine receptors in cancer

Samus, Maryna; Rot, Antal

doi:10.1016/j.cyto.2024.156504

Cited by 4 publications

(2 citation statements)

References 150 publications

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“…As suggested above, chemokine decoy receptors or atypical chemokine receptors (ACKRs) scavenge free chemokines including CCL19/CCL21, CXCL11, CXCL12, and CXCL13 without triggering intracellular signaling events [118]. These receptors arise in local microenvironments, including tumors, and can contribute to the pro-and antitumor response.…”

Section: Other Chemokines/receptorsmentioning

confidence: 99%

“…Overall, the mechanisms of decoy receptors may be more complex than their initial portrayal. Research is active to support the understanding of the biology of ACKRs, especially how and when they arise; Samus M and Rot A have extensively reviewed ACKRs in cancer as of 2024 [118], but ongoing efforts will reveal novel mechanisms at work.…”

Section: Other Chemokines/receptorsmentioning

confidence: 99%

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Immune Cell Migration to Cancer

Ryan,

Kim,

Lim

2024

Cells

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Immune cell migration is required for the development of an effective and robust immune response. This elegant process is regulated by both cellular and environmental factors, with variables such as immune cell state, anatomical location, and disease state that govern differences in migration patterns. In all cases, a major factor is the expression of cell surface receptors and their cognate ligands. Rapid adaptation to environmental conditions partly depends on intrinsic cellular immune factors that affect a cell’s ability to adjust to new environment. In this review, we discuss both myeloid and lymphoid cells and outline key determinants that govern immune cell migration, including molecules required for immune cell adhesion, modes of migration, chemotaxis, and specific chemokine signaling. Furthermore, we summarize tumor-specific elements that contribute to immune cell trafficking to cancer, while also exploring microenvironment factors that can alter these cellular dynamics within the tumor in both a pro and antitumor fashion. Specifically, we highlight the importance of the secretome in these later aspects. This review considers a myriad of factors that impact immune cell trajectory in cancer. We aim to highlight the immunotherapeutic targets that can be harnessed to achieve controlled immune trafficking to and within tumors.

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Section: Other Chemokines/receptorsmentioning

confidence: 99%

Section: Other Chemokines/receptorsmentioning

confidence: 99%

Immune Cell Migration to Cancer

Ryan,

Kim,

Lim

2024

Cells

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Atypical chemokine receptor 4 (ACKR4/CCX‐CKR): A comprehensive exploration across physiological and pathological landscapes in contemporary research

Naser,

Hamza,

Alhili

et al. 2024

Cell Biochemistry & Function

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Atypical chemokine receptor 4 (ACKR4), also known as CCX‐CKR, is a member of the chemokine receptor family that lacks typical G protein signaling activity. Instead, ACKR4 functions as a scavenger receptor that can bind and internalize a wide range of chemokines, influencing their availability and activity in the body. ACKR4 is involved in various physiological processes, such as immune cell trafficking and the development of thymus, spleen, and lymph nodes. Moreover, ACKR4 has been implicated in several pathological conditions, including cancer, heart and lung diseases. In cancer, ACKR4 plays a complex role, acting as a tumor suppressor or promoter depending on the type of cancer and the stage of the disease. For instance, ACKR4 may inhibit the growth and metastasis of breast cancer, but it may also promote the progression of hepatocellular carcinoma and gastric cancer. In inflammatory situations, ACKR4 has been found to modulate the recruitment and activation of immune cells, contributing to the pathogenesis of diseases such as myocardial infraction and pulmonary sarcoidosis. The study of ACKR4 is still ongoing, and further research is needed to fully understand its role in different physiological and pathological contexts. Nonetheless, ACKR4 represents a promising target for the development of novel therapeutic strategies for various diseases.

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