Prognostic factors of primary fallopian tube carcinoma

Abstract

Aim of the studyFallopian tube cancer is very rare in the literature and so there are not enough data about the therapeutic approaches. The approaches are generally determined in accordance with the data obtained from ovarian cancer. Many prognostic factors have been investigated in an effort to better estimate patient outcome. Stage, age, and residual tumor after surgery are consistently important prognostic factors. In this study, we aimed to evaluate the prognostic factors and survival rates of primary fallopian tube cancer (PFTC), which is rare among gynecological cancers.Material and methodsThirty-eight patients with a diagnosis of PFTC were identified through the gynecologic oncology service database of our Research and Training Hospital in the period 1995–2013. Clinicopathological and surgical data were collected. All patients were evaluated for survival and disease-free survival between the dates specified.ResultsA significant relationship and correlation was found between optimal surgery and life expectancy. Better results were obtained in patients treated with optimal surgery. The survival probability was found to be higher in patients with lower CA-125 levels and serous histologic type adenocarcinoma.ConclusionsStage is one of the factors affecting the survival probability. We determined that the pathological type of tumor, the diameter of residual tumor remaining after surgery, tumor grade, preoperative CA-125 levels and presence of ascites affect the survival probability.

Primary Fallopian Tube Carcinoma: Results of a Single-Institutional Retrospective Analysis of 17 Patients with Evaluation of Staging and Prognostic Factors

“…Our data is in accordance with other studies, the overall 5year survival was ranging from a low of 22% to a high of 57% for all stages of PFTC (3,5). Some authors advocated many prognostic factors associated with survival.…”

“…Some authors advocated many prognostic factors associated with survival. The most one was the FIGO stage (3,4,11,12). Other prognostic factors were advocated in the literature: include patient age at the time of diagnosis, residual tumor after initial surgery, and histologic tumor grade (4,12).…”

“…Primary carcinoma of the fallopian tubes (PFTC) is uncommon gynecological cancer. It constitutes (0.14-0.18%) of gynecological malignancies (1,2).PFTC had several points in common as ovarian cancer, especially factor's risk (hormonal, reproductive, and genetic factors) (3,4). Also, the management of PFTC shares similar concerns and principles as ovarian carcinoma (4).…”

Practical Means of Preoperative Diagnostics of Primary Fallopian Tube Cancer

“…Literature data mainly suggests CA-125, but reports of its diagnostic accuracy are very contradictory [2,3,8]. According to many separate observations and our data, levels of CA-125 are usually normal or dubious in the early stages of PFTC, especially if concomitant chronic diseases are present [4,11,23]. After radical surgery or chemotherapy, level of CA-125 normalizes, and increases again in cancer reactivation [8,11].…”

“…Most often it happens in patients in the early stages of the disease who undergo surgery in non-oncological profile hospitals without suspicion of malignization, which leads to nonradical surgery and delay, or even sometimes absence, of adequate treatment. Up-to-date some authors consider diagnosis of PFTC as an intraoperative finding, others -as pathoanatomical rather than clinical diagnosis [2,11,12]. Even in a specialized oncological institution correct diagnoses of PFTC during surgery were made only in 47.5% cases [7].…”