Prognostic factors of minimally invasive follicular thyroid carcinoma: Extensive vascular invasion significantly affects patient prognosis

Ito, Yasuhiro; Hirokawa, Mitsuyoshi; Masuoka, Hiroo; Yabuta, Tetsuro; Kihara, Minoru; Higashiyama, Takuya; Takamura, Yuuki; Kobayashi, Kaoru; Miya, Akihiro; Miyauchi, Akira

doi:10.1507/endocrj.ej12-0419

Cited by 83 publications

(57 citation statements)

References 26 publications

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“…Therefore, the tumor size was not recognized as an independent prognostic factor. In the subset of minimally invasive FTC, a large tumor size had a prognostic value in the series of Sugino et al [22] and ours [23]. Also, in this series, a tumor size larger than 4 cm was independently related to DFS normally consume large amount of iodine, which can explain, at least in part, the difference in prognosis of FTC, including widely invasive FTC, between foreign countries and Japan.…”

Section: Discussionsupporting

confidence: 53%

“…Age had a prognostic impact both on our entire series [3] and on the subset of minimally invasive FTC [22,23]. However, it did not show any prognostic value in widely invasive FTC patients, which was in sharp contrast to minimally invasive FTC.…”

Section: Discussionmentioning

confidence: 68%

“…Even in the subset of minimally invasive FTC, the 10-year CSS rate of M1 patients in the series of Sugino et al [22] and us [23] was 55 and 21%, respectively. In our series of widely invasive FTC, 4 of the 9 M1 patients died of FTC and, although follow-up periods are comparably short, none of M1 patients have survived for 10 years after the initial surgery.…”

Section: Discussionmentioning

confidence: 82%

“…In contrast to studies from foreign countries [25][26][27] oxyphilic cell carcinoma did not show a poorer prognosis than non-oxyphilic cell carcinoma in our study. Previous Japanese studies also showed a negative relationship between oxyphilic cell carcinoma and patients' prognosis [3,22,23]. The reason for such a discrepancy remains unknown, but there are some endemic reasons.…”

Section: Discussionmentioning

confidence: 97%

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Distant metastasis at diagnosis and large tumor size are significant prognostic factors of widely invasive follicular thyroid carcinoma

et al. 2013

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 97%

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Distant metastasis at diagnosis and large tumor size are significant prognostic factors of widely invasive follicular thyroid carcinoma

et al. 2013

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“…Western guidelines highly recommend RAI therapy for high-risk patients [4,[6][7][8]. Mazafferri et al [14] demwhich independently affected patient carcinoma death [37,39]. The present situation suggests that the pathological issue of whether follicular carcinoma is minimally or widely invasive has a very important impact on future therapy.…”

Section: Rai Ablation and Tsh Suppression Therapymentioning

confidence: 99%

Therapeutic strategy for low-risk thyroid cancer in Kanaji Thyroid Hospital [Review]

et al. 2014

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Abstract. It is well-known that differentiated thyroid carcinoma (DTC) has a generally indolent character and shows a favorable prognosis in comparison with many other carcinomas. The therapeutic strategy for patients with DTC in Japan has differed from that in Western countries. Total thyroidectomy followed by radioactive iodine (RAI) ablation has been standard in Western countries, whereas limited hemi-thyroidectomy and subtotal thyroidectomy has been extensively accepted in Japan. Papillary thyroid carcinoma (PTC) accounts for over 90% of all thyroid cancers in Japan. The majority of patients with PTC are categorized into a low-risk group on the basis of the recent risk-group classification schemes, and they show excellent outcomes. Several management guidelines for thyroid cancers have been published in Western countries. However, the optimal therapeutic options for PTC remain controversial, and high-level clinical evidence aimed at resolving these issues is lacking. Moreover, as socioeconomic differences in medical care exist, conventional policies for the treatment of PTC have differed between Japan and other countries. This review focuses on the special features of treatment in Japan for patients with low-risk DTC involving subtotal thyroidectomy without adjuvant therapies, rather than total thyroidectomy with RAI, with the aim of preserving quality of life. At our institution in Japan, we have had extensive experience with RAI treatment for high-risk DTC patients, and this represents a very rare situation. Here we introduce the therapeutic strategy for low-risk thyroid cancer in Japan, including the measures adopted at our institution.

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Hürthle cell lesions of the thyroid: Progress made and challenges remaining

Wong

Angell

Barletta

et al. 2020

Cancer Cytopathology

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Hürthle cell–predominant thyroid fine needle aspirations (FNA) are encountered frequently in routine practice, yet they are often challenging to diagnose accurately and are associated with significant interobserver variability. This is largely due to the ubiquity of Hürthle cells in thyroid pathology, ranging from nonneoplastic conditions to aggressive malignancies. Although limitations in cytomorphologic diagnoses likely will remain for the foreseeable future, our knowledge of the molecular pathogenesis of Hürthle cell neoplasia and application of molecular testing to cytologic material have increased dramatically within the past decade. This review provides context behind the challenges in diagnosis of Hürthle cell lesions and summarizes the more recent advances in diagnostic tools.

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Prognostic factors of minimally invasive follicular thyroid carcinoma: Extensive vascular invasion significantly affects patient prognosis

Cited by 83 publications

References 26 publications

Distant metastasis at diagnosis and large tumor size are significant prognostic factors of widely invasive follicular thyroid carcinoma

Distant metastasis at diagnosis and large tumor size are significant prognostic factors of widely invasive follicular thyroid carcinoma

Therapeutic strategy for low-risk thyroid cancer in Kanaji Thyroid Hospital [Review]

Hürthle cell lesions of the thyroid: Progress made and challenges remaining

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