Prognostic factors of malignant mesothelioma of the pleura

Anand, Ajay

doi:10.1002/1097-0142(19940201)73:3<755::aid-cncr2820730343>3.0.co;2-u

Cited by 1 publication

(1 citation statement)

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“…The univariate and multivariate analyses indicate our five-gene signature to be an independent prognostic factor for MPM patients. Simultaneously, our results showed that histological subtype, gender, and lymph node had relatively significant impact on prognosis, and these results were in agreement with many other researches for prognostic factors (Spirtas et al, 1988;Anand, 1994;Curran et al, 1998;Vigneswaran et al, 2017). To evaluate the accuracy and discrimination power of our risk score model, we did the ROC and C-index analyses.…”

Section: Discussionsupporting

confidence: 87%

Identification of a Five-Gene Signature for Predicting Survival in Malignant Pleural Mesothelioma Patients

et al. 2020

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Malignant pleural mesothelioma (MPM), predominantly caused by asbestos exposure, is a highly aggressive cancer with poor prognosis. The staging systems currently used in clinics is inadequate in evaluating the prognosis of MPM. In this study, a five-gene signature was developed and enrolled into a prognostic risk score model by LASSO Cox regression analysis based on two expression profiling datasets (GSE2549 and GSE51024) from Gene Expression Omnibus (GEO). The five-gene signature was further validated using the Cancer Genome Atlas (TCGA) MPM dataset. Univariate and multivariate Cox analyses proved that the five-gene signature was an independent prognostic factor for MPM. The signature remained statistically significant upon stratification by Brigham stage, AJCC stage, gender, tumor size, and lymph node status. Time-dependent receiver operating characteristic (ROC) curve indicated good performance of our model in predicting 1-and 2-years overall survival in MPM patients. The C-index was 0.784 for GSE2549 and 0.753 for the TCGA dataset showing moderate predictive accuracy of our model. Furthermore, Gene Set Enrichment Analysis suggested that the five-gene signature was related to pathways resulting in MPM tumor progression. Together, we have established a five-gene signature significantly associated with prognosis in MPM patients. Hence, the five-genes signature may serve as a potentially useful prognostic tool for MPM patients.

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Section: Discussionsupporting

confidence: 87%