Prognostic factors of drug‐resistant epilepsy in childhood: An Italian study

Russo, Angelo; Posar, Annio; Conti, Sara; Parmeggiani, Antonia

doi:10.1111/ped.12705

Cited by 8 publications

(8 citation statements)

References 29 publications

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“…In addition, the pattern of the pathological finding of MRI was also considered a risk factor for the development of intractable epilepsy. Russo et al (23) conducted a study for this purpose and found structural and heterogeneous brain malformations more frequently. In our study, structural and congenital anomalies (34.6%) were the most common pathologies found in the intractable epilepsy group.…”

Section: Discussionmentioning

confidence: 99%

Six Clinical Predictors for Intractable Childhood Epilepsy

Ayça¹,

Oral²,

Dündar³

et al. 2019

jpr

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This study aimed to determine the significance of six clinical predictors associated with medically intractable childhood epilepsy. Materials and Methods: A retrospective cohort study was conducted. A total of 241 children with diagnosed epilepsy were recruited and divided into two groups: 61 patients with intractable epilepsy, and the other 180 patients who responded well to antiepileptic drugs. We investigated seizure semiology, etiology of epileptic encephalopathy, EEG abnormalities and defined the odds ratios (ORs) of predictor factors for intractable childhood epilepsy; age of seizure onset, asphyxia, neonatal intensive care unit (NICU) history, consanguineous marriage, abnormal neuro-imaging, neuropathologic exam, prematurity, parents' seizure history. Results: According to logistic regression analysis, the major risk factors for intractable childhood epilepsy are (1) neuropathologic examination p=0.

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Section: Discussionmentioning

confidence: 99%

Six Clinical Predictors for Intractable Childhood Epilepsy

Ayça¹,

Oral²,

Dündar³

et al. 2019

jpr

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“…It has been established that the main clinical predictors of pharmacoresistance are the presence of psychiatric [82] and depressive [83,84] disorders, as well as organic brain pathology diagnosed with the MRI [85,86]. In adults, the predictors of pharmacoresistance in epilepsy include the early age of the debut, frequent seizures, failure of previous therapy, diffuse epileptiform According to some authors, an adequate choice of pharmacotherapy considering the possible drug interactions and the individual characteristics of the patient may be the way to overcome pharmacoresistance in epilepsy and concomitant diseases [88,89].…”

Section: Current Options Of Identifying Predictors Of the Antiepileptmentioning

confidence: 99%

Individual Approaches to Diagnosis and Treatment of Epilepsia (Review)

Zemlyanaya¹,

Федотчев²

2018

Sovrem Tehnol Med

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Epilepsy is one of the most common and treatment-resistant neurological diseases; it has heterogenic manifestations and requires individual approaches to its diagnosis and treatment. The ground for such approaches has been laid by modern science-based technologies, currently available in clinical practice. The aim of this review is to analyze publications on personalized approaches to the diagnosis and treatment of epilepsy over the past 10 years. In this review, we discuss the issue of individual markers of epilepsy and their predictive power, new approaches to localizing the epileptic foci, the relationship between the left-sided, right-sided and interhemispheric asymmetry and epileptogenesis, the role of comorbid disorders in epilepsy, as well as the available options for identifying the predictors of treatment efficacy.

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“…Several clinical characteristics were found to be indicative of a higher risk for resistance to ASMs. Symptomatic etiology, history of perinatal insults, earlier age of onset, history of febrile seizure, presence of multiple types of seizure, complex partial seizure, abnormalities on EEG or brain imaging, and poor response to first drug have been associated with drug resistant epilepsy [4,6,[9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Drug Resistance in Epileptic Children with Age of Onset above Five Years: A Case-Control Study

Mangunatmadja

Indra

Widodo

et al. 2021

Behavioural Neurology

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Background. Children with epilepsy with onset above five years encompass distinct epidemiological and clinical characteristics that may have specific risk factors for resistance to antiseizure medications (ASMs). Studies on this age group are limited. Purpose. To identify risk factors for drug resistance in children with epilepsy with the age of onset above five years. Methods. A case-control study was conducted on children with epilepsy with the age of onset above five years visiting the Pediatric Neurology Clinic of Cipto Mangunkusumo and Mohammad Hoesin Hospital between September 2015 and August 2016. Cases consisted of drug-resistant children while control consisted of drug-responsive children according to 2010 ILAE classification. Risk factors studied include onset, number of seizures, illness duration before treatment, cause, seizure type, status epilepticus, initial and evolution of EEG, brain imaging, and initial treatment response. Results. Thirty-two pairs of children were included in the study. After logistic regression analysis, symptomatic etiology and failure to achieve early response to treatment were found to be associated with drug resistance with adjusted OR of 84.71 (95% CI: 5.18-1359.15) and 72.55 (95% CI: 7.08-743.85), respectively. Conclusion. Poor initial response to ASM and symptomatic etiology are independent risk factors for drug resistance in children with epilepsy with the age of onset above five years.

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Prognostic factors of drug‐resistant epilepsy in childhood: An Italian study

Abstract: Predictive factors of DR can be recognized in a large number of patients with epilepsy at disease onset, although the current possibility of predicting epilepsy outcome remains limited. In the long term, evidence of cerebral lesions appears to become the most significant prognostic factor.

Cited by 8 publications

References 29 publications

Six Clinical Predictors for Intractable Childhood Epilepsy

Six Clinical Predictors for Intractable Childhood Epilepsy

Individual Approaches to Diagnosis and Treatment of Epilepsia (Review)

Risk Factors for Drug Resistance in Epileptic Children with Age of Onset above Five Years: A Case-Control Study

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