Prognostic Factors in Operated T3-T4 Gastric Cancer

Uzun, Orhan; Gülmez, Şelçuk; Senger, Aziz Serkan; Percem, Askin Kadir; Polat, Erdal; Duman, Mustafa

doi:10.29271/jcpsp.2020.10.1047

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…The first surgical procedure in TLDG is to resect the distal stomach and perigastric lymph nodes radically, which accounts for primary intraoperative bleeding and embodies the oncological safety of the surgery [ 11 ]. In the present study, this procedure in the B-IIB and R-Y groups is almost identical and performed in a standardized way, which could explain the results that the number of retrieved lymph nodes and intraoperative bleeding did not differ between the study groups.…”

Section: Discussionmentioning

confidence: 99%

Billroth-II with Braun versus Roux-en-Y reconstruction in totally laparoscopic distal gastrectomy for gastric cancer.

Chi¹,

Lan²,

Bi³

et al. 2021

Videosurgery and Other Miniinvasive Techniques

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Introduction: Totally laparoscopic distal gastrectomy (TLDG) has been increasingly adopted for the treatment of gastric cancer. Both Billroth-II with Braun (B-IIB) reconstruction and Roux-en-Y (R-Y) reconstruction are commonly performed in TLDG; however, which of these reconstruction techniques is better remains unclear. Aim: To compare the efficacy of B-IIB reconstruction and R-Y reconstruction in TLDG for gastric cancer. Material and methods: A total of 105 gastric cancer patients who underwent TLDG with B-IIB or R-Y reconstruction were reviewed from January 2019 to July 2020. Clinicopathological characteristics and perioperative data of the B-IIB and R-Y groups were compared. Results: Clinicopathological characteristics were not significantly different between the B-IIB and R-Y groups. The average total operative time for the R-Y group (161.9 ±20.7 min) was significantly longer than that for the B-IIB group (141.9 ±16.7 min). The average anastomosis time for the R-Y group (25.5 ±4.1 min) was also significantly longer than that for the B-IIB group (18.9 ±3.3 min). Blood loss volume, number of retrieved lymph nodes, time to first flatus, average length of postoperative hospital stay, inflammatory parameters and postoperative complications did not differ between the two groups. Conclusions: Both B-IIB reconstruction and R-Y reconstruction are safe and effective in TLDG. B-IIB reconstruction is easier and faster to perform than R-Y reconstruction in TLDG.

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Section: Discussionmentioning

confidence: 99%

Billroth-II with Braun versus Roux-en-Y reconstruction in totally laparoscopic distal gastrectomy for gastric cancer.

Chi¹,

Lan²,

Bi³

et al. 2021

Videosurgery and Other Miniinvasive Techniques

View full text Add to dashboard Cite

show abstract

“…GC is divided into early GC (stage I and II) and advanced GC (stage III or higher tumors) ( 36 – 38 ), and there are differences in treatment and surgical methods between early and advanced GC ( 39 , 40 ). Uzun et al ( 41 ) revealed that T1-T2 and T3-T4 classifications of patients with GC showed differences in their clinicopathological characteristics and survival status. T3-T4 classification was an important indicator for patients with GC to choose GC chemotherapy and surgical procedures ( 42 , 43 ).…”

Section: Discussionmentioning

confidence: 99%

“…According to the American Joint Committee on Cancer Staging System (8 th edition) ( 31 ), and the differences in treatment and surgical methods between early gastric cancer group (stage I and II) and advanced gastric cancer group (stage III or higher tumors) ( 36 – 40 ), patients with GC with regards to pathological stage were divided into the early GC group (stage I and II) and advanced GC group (stage III or higher tumors). According to the United States Joint Committee on Cancer Staging System (8 th edition) ( 31 ) and the differences between T3-T4 group and T1-T2 classification group with GC in chemotherapy and surgery ( 41 – 43 ), patients with GC in tumor (T) classification were divided into the T1-T2 and T3-T4 groups.…”

Section: Methodsmentioning

confidence: 99%

hsa_circ_0060975 is highly expressed and predicts a poor prognosis in gastric cancer

Zhang

et al. 2021

Oncol Lett

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Gastric cancer (GC) is the fifth most common cancer and GC has a high mortality rate worldwide. Circular (circ) RNAs serve an important role in cancer. The present study aimed to investigate the expression level of hsa_circ_0060975 in gastric cancer (GC) and to determine the clinical pathological significance of hsa_circ_0060975 in patients with GC. Reverse transcription-quantitative PCR was used to detect expression level of hsa_circ_0060975 in 192 GC and adjacent non-cancerous gastric tissues, in GC cell lines (MKN-45, HGC27 and AGS) and a human gastric epithelium cell line (GES-1), as well as in plasma samples from 126 patients with GC and 92 healthy volunteers. All plasma and tissue samples of were obtained from The First Affiliated Hospital of Anhui Medical University (Hefei, China). The relationship between hsa_circ_0060975 expression and clinical pathological factors was analyzed using the χ 2 test. The diagnostic value of hsa_circ_0060975 was analyzed using the receiver operating characteristic curve (ROC curve), while the Kaplan-Meier method was used to analyze the relationship of hsa_circ_0060975 expression with the survival of patients with GC as determined by log-rank tests. Univariate and multivariate Cox regression analyses were used to identify the prognostic factors, including hsa_circ_0060975 expression and clinical pathological factors. In addition, the potential function of hsa_circ_0060975 was evaluated via bioinformatics analysis. The expression level of hsa_circ_0060975 was higher in GC tissues compared with adjacent non-cancerous gastric tissues, GC cell lines compared with GES-1 and plasma samples from patients with GC compared with plasma samples from healthy volunteers. In addition, higher hsa_circ_0060975 expression was associated with histological grade, pathological stage and tumor (T) classification in GC tissues and plasma samples (P<0.05). The area under the ROC curves of hsa_circ_0060975, the combination with hsa_circ_0060975 and carcinoembryonic antigen (CEA) or CEA alone were 0.804 (sensitivity, 0.746; specificity, 0.783; P<0.001); 0.931 (sensitivity, 0.937; specificity, 0.870; P<0.001) and 0.924 (sensitivity, 0.937; sspecificity, 0.804; P<0.001) respectively. The Kaplan-Meier survival analysis revealed that the overall survival (OS) and disease-free survival (DFS) time of patients with higher hsa_circ_0060975 expression were shorter compared with those in patients with lower hsa_circ_0060975 expression. Univariate and multivariate Cox regression analyses in OS and DFS time determined that the expression level of hsa_circ_0060975, histological grade and pathological stage were independent prognostic factors for patients with GC. In addition, the bioinformatics analysis results suggested that the abnormal expression of hsa_circ_0060975 may serve an important role in tumorigenesis. Hence, hsa_circ_0060975 expression may be an independent prognostic factor for patients with GC and may be a potential marker for biological malignancy.

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The significance of the tumor microenvironment and molecular biological parameters in assessing the prognosis of the disease in patients with early-stage gastric cancer

Rumyantseva¹,

Avdalyan²,

Ivanov³

et al. 2023

Onkol. Z. im. P.A. Gercena

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Prognostic Factors in Operated T3-T4 Gastric Cancer

Abstract: Objective: To investigate the prognostic factors affecting survival in patients with a deep gastric wall invasion of T3-T4 advanced gastric cancer. Study Design: Descriptive study.

Cited by 3 publications

References 18 publications

Billroth-II with Braun versus Roux-en-Y reconstruction in totally laparoscopic distal gastrectomy for gastric cancer.

Billroth-II with Braun versus Roux-en-Y reconstruction in totally laparoscopic distal gastrectomy for gastric cancer.

hsa_circ_0060975 is highly expressed and predicts a poor prognosis in gastric cancer

The significance of the tumor microenvironment and molecular biological parameters in assessing the prognosis of the disease in patients with early-stage gastric cancer

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