Prognostic Factors in Follicular Lymphoma

Relander, Thomas; Johnson, Nathalie A.; Farinha, Pedro; Connors, Joseph M.; Sehn, Laurie H.; Gascoyne, Randy D.

doi:10.1200/jco.2009.26.1693

Cited by 135 publications

(118 citation statements)

References 178 publications

Supporting

Mentioning

112

Contrasting

Order By: Relevance

“…The present study found no difference in survival between t(14;18)-positive and -negative groups in conjunction with studies of extranodal follicular lymphomas outside the ocular adnexal region (Goodlad et al 2004;Weinberg et al 2009;Relander et al 2010). However, only patients with the t(14;18) had recurrence.…”

Section: Discussionsupporting

confidence: 64%

Follicular lymphoma of the ocular adnexal region: A nation‐based study

Rasmussen

Ralfkiær

Prause

et al. 2014

Acta Ophthalmologica

View full text Add to dashboard Cite

ABSTRACT.Purpose: To characterize the clinicopathological features of follicular lymphoma of the ocular adnexal region. Methods: Retrospective nation-based study of Danish patients with ocular adnexal follicular lymphoma from January 1st 1980 through December 31st 2009. Results: Twenty-four patients with ocular adnexal follicular lymphoma were identified. Fourteen (58%) of the patients were females. The median age was 63 years (range: 42-96 years). Eleven (46%) of the patients had primary ocular adnexal lymphoma, seven (29%) had an ocular adnexal lesion in conjunction with a concurrent systemic lymphoma and six patients (25%) presented with an ocular adnexal relapse. The most frequently affected sites were the lacrimal gland (38%) and the orbit (33%). Thirteen patients (54%) presented with Ann Arbor stage IE lymphoma, four (17%) had stage IIE, two patients (8%) stage IIIE, and five patients (21%) had stage IV lymphoma. Radiotherapy was primarily used in patients with primary lymphoma and those with a stage IE/IIE relapse (82%), while stage IIIE/IV lymphomas most frequently received alkylating chemotherapy (67%). Complete remission was observed in 19 of the patients (79%), but of these 11(58%) had a relapse. The 10-year overall survival for the entire cohort was 59%. The translocation t(14;18) was detected in 16 patients (16/24, 76%). Recurrence was only observed in patients with the t(14;18) (p = 0.05, log-rank). Conclusions: Ocular adnexal follicular lymphoma is more commonly found in elderly female patients. The lacrimal gland is relatively frequently involved. Radiotherapy is the treatment of choice for localized ocular adnexal follicular lymphoma providing a favourable prognosis for majority of patients.

show abstract

Section: Discussionsupporting

confidence: 64%

Follicular lymphoma of the ocular adnexal region: A nation‐based study

Rasmussen

Ralfkiær

Prause

et al. 2014

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…2 Summerfield et al, 11 studying 46 follicular lymphoma patients under 40 years of age, found that 74% were Ann Arbor stages III and IV. In our series, these stages corresponded to 66% (56 of the 85).…”

Section: Discussionmentioning

confidence: 99%

“…1,2 It is the commonest form of indolent B-cell lymphoma, and is clinically manifested with multiple relapses and remissions. The median age at diagnosis is about 60 years and there is a slight female predominance.…”

mentioning

confidence: 99%

Follicular lymphoma in young adults: a clinicopathological and molecular study of 200 patients

et al. 2013

View full text Add to dashboard Cite

Follicular lymphoma is clinically heterogenous, and therefore necessitates the identification of prognostic markers to stratify risk groups and optimize clinical management. It is relatively rare in patients younger than 40 years, and the clinicopathologic characteristics and biological behavior in this age group are poorly understood. In the current study, samples from a cohort of 200 patients between 19 and 40 years were evaluated retrospectively with respect to clinical, histologic, and genetic features. These were then correlated with clinical outcome. The median age at presentation was 35 years with a slight female prepoderance (56%). Most of the cases are presented with nodal disease (90%). Concomitant follicular lymphoma and diffuse large B-cell lymphoma were observed in 7 (4%) patients. Immunohistologic studies showed the expression of CD10 (91%), BCL6 (97%), BCL2 (95%), MUM1/IRF4 (12%), MDM2 (17%), and CD23 (25%). BCL2 rearrangement was present in 74%, and BCL6 in 20%. The estimated overall survival of patients was 13 years (mean). The presence of anemia, elevated lactose dehydrogenase, bone marrow involvement, and high-risk follicular lymphoma international prognostic index correlated with adverse overall survival. Our findings revealed that follicular lymphoma in young adults demonstrate similarities with that of older adults, including the frequency of presentation at various anatomic sites, grade, and adverse prognostic factors.

show abstract

“…It is also likely that specific types of treatment influence or modify the prognostic impact of certain parameters in the microenvironment. 6,11 Another possible explanation for the contradictory results is variation in the immunohistochemical staining and scoring across laboratories. We have previously shown that the reproducibility of scoring immunohistochemical stainings is poor and often inadequate for several frequently reported markers expressed on lymphoma cells in diffuse large B-cell lymphoma (DLBCL).…”

mentioning

confidence: 99%

The reliability of immunohistochemical analysis of the tumor microenvironment in follicular lymphoma: a validation study from the Lunenburg Lymphoma Biomarker Consortium

et al. 2014

View full text Add to dashboard Cite

The cellular microenvironment in follicular lymphoma is of biological and clinical importance. Studies on the clinical significance of non-malignant cell populations have generated conflicting results, which may partly be influenced by poor reproducibility in immunohistochemical marker quantification. In this study, the reproducibility of manual scoring and automated microscopy based on a tissue microarray of 25 follicular lymphomas as compared to flow cytometry is evaluated. The agreement between manual scoring and flow cytometry was moderate for CD3, low for CD4, and moderate to high for CD8, with some laboratories scoring closer to the flow cytometry results. Agreement in manual quantification across the 7 laboratories was low to moderate for CD3, CD4, CD8 and FOXP3 frequencies, moderate for CD21, low for MIB1 and CD68, and high for CD10. Manual scoring of the architectural distribution resulted in moderate agreement for CD3, CD4 and CD8, and low agreement for FOXP3 and CD68. Comparing manual scoring to automated microscopy demonstrated that manual scoring increased the variability in the low and high frequency interval with some laboratories showing a better agreement with automated scores. Manual scoring reliably identified rare architectural patterns of T-cell infiltrates. Automated microscopy analyses for T-cell markers by two different instruments were highly reproducible and provided acceptable agreement with flow cytometry. These validation results provide explanations for the heterogeneous findings on the prognostic value of the microenvironment in follicular lymphoma. We recommend a more objective measurement, such as computer-assisted scoring, in future studies of the prognostic impact of microenvironment in follicular lymphoma patients.

show abstract

Prognostic Factors in Follicular Lymphoma

Cited by 135 publications

References 178 publications

Follicular lymphoma of the ocular adnexal region: A nation‐based study

Follicular lymphoma of the ocular adnexal region: A nation‐based study

Follicular lymphoma in young adults: a clinicopathological and molecular study of 200 patients

The reliability of immunohistochemical analysis of the tumor microenvironment in follicular lymphoma: a validation study from the Lunenburg Lymphoma Biomarker Consortium

Contact Info

Product

Resources

About