Prognostic factors in epithelial ovarian cancer: A population-based study

Abstract

The overall survival (OS) of patients with ovarian cancer is poor while epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer. The aim of the present study was to evaluate the clinico-pathologic characteristics, especially the prognostic factors, for patients with epithelial ovarian cancer (EOC) in Taiwan. Information about newly diagnosed patients with EOC from 2009 to 2012 was retrieved from the database of the Taiwan Cancer Registry. Data from 2009 to 2013 for the respective cases from the claims database of Taiwan’s National Health Insurance and National Death Registry were then retrieved. Potential prognostic factors were analyzed. The mean age at diagnosis of the 2,498 patients was 52.8 years. Serous carcinoma and clear cell carcinoma were diagnosed in 43.3% and 22.8% of the total patients, respectively. For patients with early-stage disease, taxane-based adjuvant chemotherapy, stage I, and younger age at diagnosis led to better overall survival (p = 0.030, p = 0.002, p<0.001, respectively) in multivariable analysis. For advanced-stage patients, histology (endometrioid type), taxane-based adjuvant chemotherapy, stage, and age at diagnosis had a significant impact on OS (p<0.001, p = 0.020, p<0.001, p<0.001, respectively). In conclusion, taxane-based chemotherapy impacts the outcome of patients with EOC. Personalized medicine may be needed for different histological types of EOC because of their different outcomes.

<p>Parity as a Prognostic Factor in Patients with Advanced-Stage Epithelial Ovarian Cancer</p>

“…A change in the peak age at diagnosis from approximately 60 years old to 50 years old From 1979 to 2008 was reported in a study by Chiang et al 2 The mean age at diagnosis of the patients with EOC was reported as 52.8 years old in another study. 11 However, the mean age at diagnosis in the present study was 49 years old which was lower than those of the previously mentioned studies. 2,11 The percentage of ESEOC patients was 34.3% during the study period in the present study.…”

“…11 However, the mean age at diagnosis in the present study was 49 years old which was lower than those of the previously mentioned studies. 2,11 The percentage of ESEOC patients was 34.3% during the study period in the present study. The percentage of ESEOC patients in the current study was lower than a previous study which reported the percentage of earlystage patients as 44.4%.…”

“…The percentage of ESEOC patients in the current study was lower than a previous study which reported the percentage of earlystage patients as 44.4%. 11 Regarding the histologic subtype, the most common histologic subtype of EOC in the present study was serous carcinoma (82.9%) followed by mucinous carcinoma (10.1%). The pattern of histological types varied across the studies.…”

“…Also, patients ≥60 years old had poorer overall survival than those <60 years old. 11 In contrast, tumor grade, chemotherapeutic regimens/cycles, and stage were found to be independent prognostic factors for early-stage EOC in another study. Moreover, no significant differences were found between histologic types and the 5-year OS.…”

Ovarian Cancer, Cancer Stem Cells and Current Treatment Strategies: A Potential Role of Magmas in the Current Treatment Methods

“…Among malignant gynaecologic diseases, OC has the second highest incidence in Western countries after cervical cancer, and the third highest prevalence in Asian countries [3]. Prognostic factors for advanced OC include age, post treatment residual tumour volume, tumour histology, presence or absence of ascites, and serum CA-125 levels [4]. A combination of taxane and platinum-based therapies has been the standard treatment of OC for more than four decades.…”