Prognostic factors in Burkitt's lymphoma importance of total tumor burden

Magrath, Ian; Lee, Young Jack; Anderson, Tom; Henle, Werner; Ziegler, John L.; Simon, Richard; Schein, Philip S.

doi:10.1002/1097-0142(19800315)45:6<1507::aid-cncr2820450634>3.0.co;2-d

Cited by 103 publications

(30 citation statements)

References 18 publications

(3 reference statements)

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“…Our findings may provide a molecular basis for altered tumor glycolysis when the Warburg effect and previous links between elevated LDH-A levels and human cancers are taken into consideration (2,58,59). In particular, an elevated LDH level is an independent predictor of poor clinical outcome in Burkitt lymphoma, a disease characterized by activation of the c-myc gene by chromosomal translocations (17,59,60). An elevation of lactate production in a transgenic mouse model that overexpresses c-Myc in the liver further supports the ability of c-Myc to induce the Warburg effect (61).…”

Section: Discussion C-myc Regulates the Expression Of Ldh-amentioning

confidence: 99%

c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth

Shim

Dolde

Lewis

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

956

716

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Cancer cells are able to overproduce lactic acid aerobically, whereas normal cells undergo anaerobic glycolysis only when deprived of oxygen. Tumor aerobic glycolysis was recognized about seven decades ago; however, its molecular basis has remained elusive. The lactate dehydrogenase-A gene (LDH-A), whose product participates in normal anaerobic glycolysis and is frequently increased in human cancers, was identified as a c-Myc-responsive gene. Stably transfected Rat1a fibroblasts that overexpress LDH-

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Section: Discussion C-myc Regulates the Expression Of Ldh-amentioning

confidence: 99%

c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth

Shim

Dolde

Lewis

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

956

716

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“…Its concentration rises during tumor growth. Serum LDH level has significant correlation with total tumor burden 8 . There is a good relationship between serum LDH level and the course of neoplasia and the degree of dissemination of the neoplastic process.…”

Section: Introductionmentioning

confidence: 99%

Serum lactate dehydrogenase level in childhood acute lymphoblastic leukemia

Hafiz

Mannan

2008

Bangladesh Med Res Counc Bull

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Serum lactate dehydrogenase (LDH) level was estimated in 44 childhood (age range 1-15 years) acute lymphoblastic leukemia (ALL) on admission, day 14 and day 29 of induction. Another 25 children without ALL were included as control. On admission, the level of serum LDH was significantly high in ALL cases than control (p<0.001). Total WBC count was significantly decreased along with serum LDH level at day 14 and day 29 of induction (p<0.001). A significant rise of platelet count was observed at day 29 of induction in relation to significant decrease of serum LDH level (p<0.001). A significant decrease of peripheral and bone marrow blast cell percentages were also observed at day 29 of induction along with significant decrease level of serum LDH (p<0.001). So, the measurement of serum LDH level can be accepted as an enzymatic tool for presumption of childhood ALL and the response to chemotherapy during induction of remission.

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“…22,52 Increased access to more advanced imaging studies (ie, CT or improved ultrasonography), diagnostic laboratory studies (such as lactate dehydrogenase, uric acid, and Epstein-Barr viral load monitoring), and radiology-guided biopsy procedures may improve uptake of pathologically confirmed diagnoses for abdominal lymphomas. 12,53 …”

Section: Discussionmentioning

confidence: 99%

Beyond Endemic Burkitt Lymphoma: Navigating Challenges of Differentiating Childhood Lymphoma Diagnoses Amid Limitations in Pathology Resources in Lilongwe, Malawi

El‐Mallawany

Mutai

Mtete

et al. 2017

Global Pediatric Health

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Background. Although Burkitt lymphoma (BL) is the most common childhood lymphoma in sub-Saharan Africa, Hodgkin lymphoma (HL) and other non-Hodgkin lymphomas occur. Diagnosing non-jaw mass presentations is challenging with limited pathology resources. Procedure. We retrospectively analyzed 114 pediatric lymphomas in Lilongwe, Malawi, from December 2011 to June 2013 and compared clinical versus pathology-based diagnoses over two time periods. Access to pathology resources became more consistent in 2013 compared with 2011-2012; pathology interpretations were based on morphology only. Results. Median age was 8.4 years (2.1-16.3). The most common anatomical sites of presentation were palpable abdominal mass 51%, peripheral lymphadenopathy 35%, and jaw mass 34%. There were 51% jaw masses among clinical diagnoses versus 11% in the pathology-based group (P < .01), whereas 62% of pathology diagnoses involved peripheral lymphadenopathy versus 16% in the clinical group (P < .01). The breakdown of clinical diagnoses included BL 85%, lymphoblastic lymphoma (LBL) 9%, HL 4%, and diffuse large B-cell lymphoma (DLBCL) 1%, whereas pathology-based diagnoses included HL 38%, BL 36%, LBL 15%, and DLBCL 11% (P < .01). Lymphoma diagnosis was pathology confirmed in 19/66 patients (29%) in 2011-2012 and 28/48 (60%) in 2013 (P < .01). The percentage of non-BL diagnoses was consistent across time periods (35%); however, 14/23 (61%) non-BL diagnoses were pathology confirmed in 2011-2012 versus 16/17 (94%) in 2013. Conclusions. Lymphomas other than Burkitt accounted for 35% of childhood lymphoma diagnoses. Over-reliance on clinical diagnosis for BL was a limitation, but confidence in non-BL diagnoses improved with time as pathology confirmation became standard. Increased awareness of non-BL lymphomas in equatorial Africa is warranted.

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Prognostic factors in Burkitt's lymphoma importance of total tumor burden

Cited by 103 publications

References 18 publications

c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth

c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth

Serum lactate dehydrogenase level in childhood acute lymphoblastic leukemia

Beyond Endemic Burkitt Lymphoma: Navigating Challenges of Differentiating Childhood Lymphoma Diagnoses Amid Limitations in Pathology Resources in Lilongwe, Malawi

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