Prognostic Factors in Adult Patients with Non-Cystic Fibrosis Bronchiectasis

Machado, Betina Charvet; Jacques, Patrícia Santos; Penteado, Louise Piva; Dalcin, Paulo de Tarso Roth

doi:10.1007/s00408-018-0165-z

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…Although the pathophysiology for most etiologies remains incompletely understood, the commonly accepted “vicious cycle” hypothesis states that there is a reinforcing cycle of inflammation producing airway damage, impaired mucociliary clearance, and frequent respiratory infections, which then cause further inflammation . Bronchiectasis remains an unresolved worldwide cause of impaired quality of life, increased mortality, and significant economic burden …”

mentioning

confidence: 99%

Prevalence and characterization of chronic rhinosinusitis in patients with non‒cystic fibrosis bronchiectasis at a tertiary care center in the United States

Somani

Kwah

Chen

et al. 2019

Int Forum Allergy Rhinol

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Background: Chronic rhinosinusitis (CRS) is associated with bronchiectasis; however, this relationship has not been well studied in the United States (US) population. In this work we aimed to determine the prevalence of CRS among patients with bronchiectasis affiliated with a US tertiary medical center and identify which comorbid diseases are associated with the presence of CRS in patients with bronchiectasis. Methods:This was a retrospective cohort study in which data were obtained from a large database warehouse at a tertiary care center. Patients with bronchiectasis were identified from 2007 to 2017 using diagnosis codes from the the ninth and tenth revisions of the International Classification of Diseases (ICD-9/10) and confirmed by radiographic evidence of bronchiectasis on chest computed tomography (CT) scans. Patients were divided into cohorts based on presence or absence of concomitant CRS. Characteristics analyzed included demographics, comorbidities, peripheral eosinophil counts, and pulmonary function testing.Results: CRS was present in 45% (408 of 900) of patients with bronchiectasis. Females represented a majority of bronchiectasis patients, both with and without CRS (69% and 64%, respectively, p = 0.09). A er controlling for demographic factors, asthma (p < 0.01), allergic rhinitis (p < 0.01), gastroesophageal reflux disease (p < 0.01), and antibody deficiency (p < 0.01) were associated with the presence of CRS in patients with bronchiectasis.Conclusion: CRS had a high prevalence and was associated with numerous comorbid conditions in patients with bronchiectasis. These findings have clinical implications for the treatment of patients with bronchiectasis and future research. C 2019 ARS-AAOA, LLC.

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mentioning

confidence: 99%

Prevalence and characterization of chronic rhinosinusitis in patients with non‒cystic fibrosis bronchiectasis at a tertiary care center in the United States

Somani

Kwah

Chen

et al. 2019

Int Forum Allergy Rhinol

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“…less severe) than non‐Indigenous Australian and New Zealand patients . In the Brazilian study, both the BSI and FACED scores (graded as mild, moderate and severe disease) were inaccurate at predicting mortality, although the overall FACED score was better ( P = 0.001) than BSI ( P = 0.29) at predicting unfavourable outcomes (mortality or lung transplantation) in this cohort . Also unlike other cohorts, tuberculosis predominated as the underlying aetiology (33% of cohort) in the Brazilian cohort where mortality was relatively high (39% after an average of 5.5 years of follow‐up).…”

Section: Epidemiologymentioning

confidence: 68%

“…In contrast, the FACED score (range: 0–7) consists of five dichotomized variables: FEV 1 , age, colonization with P. aeruginosa , extent of bronchiectasis (number of affected lung lobes seen on chest computed tomography (CT) scans) and dyspnoea . However, agreement between these scores and their predictive values varies, which as suggested by two recent studies likely reflects bronchiectasis heterogeneity and outcomes . The Australian‐New Zealand study highlighted outcome disparities where the mortality gap between Indigenous and non‐Indigenous patients was ~22 years in Australia and 4.3 years in New Zealand.…”

Section: Epidemiologymentioning

confidence: 99%

Contemporary Concise Review 2018: Bronchiectasis

Chang

Grimwood

2019

Respirology

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“…Thus, we conducted a crosssectional and observational study that may minimize the risk of selection bias. Second, pulmonary function test results are shown to be associated with poor prognosis in bronchiectasis patients [48]; however, this study does not include pulmonary function tests. A previous study has shown that serial CT changes were correlated with the pulmonary function trends [44]; hence, we used CT findings to evaluate the severity of bronchiectasis.…”

Section: Discussionmentioning

confidence: 94%

Clinical impact of cardiovascular disease on patients with bronchiectasis

et al. 2020

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Background: Patients with bronchiectasis have a higher cardiovascular risk than their matched controls. However, the effect of cardiovascular (CV) disease on bronchiectasis remains unclear. Thus, we aimed to investigate the clinical impacts of cardiovascular disease on adult patients with bronchiectasis. Methods: The study cohort comprised 603 consecutive inpatients diagnosed with bronchiectasis in the Affiliated Yancheng Hospital of Southeast University Medical College (Jiangsu, China) from January 2014 to December 2017. Symptoms, bacterial cultures, blood biochemical indicator levels, and chest high-resolution computed tomography scans were assessed during their initial hospitalization for bronchiectasis. Three hundred and thirty five subjects finished 1 year follow-up after their hospital discharge. Results: Three hundred thirty five patients had at least one bronchiectasis exacerbation during the 1-year follow-up period. Patients with CV comorbidities were more likely to present with symptoms of wheezing (65.3%) and had a higher levels of brain natriuretic peptide (P < 0.001) and D-dimer (P < 0.001) than those without CV comorbidities. Independent risk factors associated with bronchiectasis exacerbations were the presence of comorbidities of cardiovascular diseases (odds ratio [OR] 2.503, 95% confidence interval [CI] 1.298-4.823; P = 0.006), the isolation of Pseudomonas aeruginosa (OR 2.076, 95% CI 1.100-3.919; P = 0.024), and extension to more than two lobes (OR 2.485, 95% CI 1.195-5.168; P = 0.015). Conclusion: The existence of cardiovascular disease was independently associated with increased bronchiectasis exacerbation.

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Prognostic Factors in Adult Patients with Non-Cystic Fibrosis Bronchiectasis

Cited by 7 publications

References 25 publications

Prevalence and characterization of chronic rhinosinusitis in patients with non‒cystic fibrosis bronchiectasis at a tertiary care center in the United States

Prevalence and characterization of chronic rhinosinusitis in patients with non‒cystic fibrosis bronchiectasis at a tertiary care center in the United States

Contemporary Concise Review 2018: Bronchiectasis

Clinical impact of cardiovascular disease on patients with bronchiectasis

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