Prognostic factors in adenocarcinoma of the salivary glands

Positive surgical margins in parotid malignancies: Institutional variation and survival association

“…We speculate that we may have not found a survival association with positive margins in adenoid cystic carcinoma because these patients are prone to recurrence delayed beyond the 10‐year timeframe we were able to analyze. In a series of 51 patients with adenocarcinoma, Huang et al found an association of positive margins with OS (HR = 4.6 [95% CI: 1.8‐11.5], P < .001) . However, in a review of 155 patients with acinic cell carcinoma Neskey et al found no association of surgical margins with OS or local recurrence .…”

“…Major salivary gland cancer is rare, making up <1% of the cancer cases diagnosed each year . In addition, different histologic types have different management and prognoses . Surgery is generally recommended for resectable tumors, with adjuvant therapy indicated for high‐grade, tumor spillage or invasion, nodal metastases, and close or positive margins…”

“…Positive margin rates are higher in parotid tumors than in many other cancer sites, likely due to the proximity of the parotid gland to critical structures, including the facial nerve, which is generally spared unless grossly involved . Positive margins are an indication for postoperative radiotherapy (RT) and independently predictive of poor prognosis . Studies have shown institutional variation in positive margin rates at other cancer subsites, likely reflective of inconsistent quality of care across institutions .…”

Profiling of 149 Salivary Duct Carcinomas, Carcinoma Ex Pleomorphic Adenomas, and Adenocarcinomas, Not Otherwise Specified Reveals Actionable Genomic Alterations

“…The genetic underpinnings of adenocarcinoma, NOS are largely unknown. Both adenocarcinoma, NOS and SDC are associated with a worse prognosis than other SGCs, heightening the need for novel, precise therapies (13).…”

Neutrophil to lymphocyte ratio is an independent prognostic factor in patients with recurrent or metastatic head and neck squamous cell cancer

“…In 2014, 12,000 mortalities were expected to occur from head and neck cancer (2). Several factors affect survival and locoregional tumor control in patients with HNSCC (3)(4)(5)(6). In order to better define the risks, analyses of prognostic factors and outcomes have been performed in a number of trials.…”