Prognostic Factors for Tuberculosis Development in Children With Latent Tuberculosus Infection

Корнева, Н. В.; Старшинова, Анна; Ananiev, S.; Ovchinnikova, Yu. E.; Dovgalyuk, I. F.

doi:10.21292/2075-1230-2016-94-6-14-19

Cited by 6 publications

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“…Thus, the test specificity was 99.0-99.7% (20). The high effectiveness of the test in clinical practice has been confirmed by many authors (21)(22)(23). Studies have demonstrated that the use of the RTA test for TB screening has significantly increased the detection rate of tuberculosis in primary health care facilities (in schoolchildren 8-17 years of age, it is 37-fold higher than that with the use of the Mantoux test) (24).…”

Section: Discussionmentioning

confidence: 84%

Evaluation of the specificity of an intradermal test with recombinant tuberculosis allergen in Bacillus Calmette–Guérin-vaccinated healthy volunteers

et al. 2023

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IntroductionThe tuberculin skin test has significant limitations for use in individuals vaccinated with BCG. The presence in the genome of Mycobacterium tuberculosis of the RDI region, which is absent in the genome of Mycobacterium bovis BCG and most non-tuberculous mycobacteria, made it possible to develop new skin tests, which include a skin test with a recombinant tuberculosis allergen [RTA (Diaskintest®, JSC Generium, Russia)]. Diaskintest has shown high diagnostic performance in clinical trials and in conditions of high prevalence of tuberculosis infection. In 2021, the Russia was excluded from the WHO list of high TB burden countries, which makes relevant an assessment of the specificity of the RTA test under conditions of low epidemiologic risk for tuberculosis to confirm the high specificity of the test.Study objectiveTo assess the specificity of Diaskintest in the regions of the Russian Federation with low epidemiologic risk for tuberculosis.MethodsA multicenter, open-label, prospective study was conducted, which included 150 healthy volunteers aged 18–30 years old, vaccinated with BCG, who were not at risk of tuberculosis, from regions with low epidemiologic risk (Oryol region, Ryazan region, and Arkhangelsk region). During the study, 4 visits were scheduled for each participant: [Visit 0 (screening), Visit 1, Visit 2 (in 72 h) and Visit 3 (in 28 days)]. All participants, who excluded active and latent tuberculosis infection, underwent a test with RTA. To assess the safety of RTA tests, all systemic and local adverse events that occurred during 28 days were recorded. The trial was filed in the NIH clinical trials database ClinicalTrials.gov (NCT05203068).ResultsIn individuals with a negative T-SPOT.TB test, the specificity of the RTA test was 97% (95% CI: 92–99%) with a cut-off of >0 mm. The study findings confirm data 2009: 100.00 (95% CI: 94–100). When evaluating the safety of the RTA test during 28 days of follow-up, the participants did not report local and systemic adverse reactions that had a causal relationship with the RTA test.ConclusionDiaskintest is highly specific and safe, therefore it is a valuable tool as a screening test for early detection of tuberculosis.

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Section: Discussionmentioning

confidence: 84%

Evaluation of the specificity of an intradermal test with recombinant tuberculosis allergen in Bacillus Calmette–Guérin-vaccinated healthy volunteers

et al. 2023

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“…В первом десятилетии XXI столетия в России произошли серьезные изменения в диагностике туберкулезной инфекции у взрослого и детского Оригинальные статьи Original Articles населения. Появились новые диагностические им мунологические тесты с высокой чувствительно стью и специфичностью, позволившие выявлять предболезнь (латентную туберкулезную инфек цию -ЛТИ) еще до развития локальной формы туберкулеза как у детей, так и у взрослых [5][6][7][8][9][10][11].…”

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Possibilities of Detecting an Epidemic Focus of Tuberculosis Infection in an Indicator Patient with a Positive Immunological Test for Tuberculosis

Oganezova,

Bogorodskaya,

Briko

et al. 2023

Epidemiology and Vaccinal Prevention

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Relevance. In connection with the advent of new diagnostic immunological tests, it became possible to determine a potential focus of infection not only through the identification of patients with tuberculosis, but also through the identification of patients infected with M. tuberculosis, who still do not have manifestations of a local form of the disease. This made it possible to search for persons who were infected with an unknown source of tuberculosis infection in order to conduct an in-depth epidemiological investigation and detect hitherto unknown foci of tuberculosis. Aims. To study the effectiveness of identifying the source of infection in the environment of a patient with a positive immunological test for tuberculosis («indicator» patient). Materials and methods. 1) A retrospective study of the data of all 30 patients with tuberculosis in the period from 2014 to 2019 in Moscow, identified by indicator patients with a positive immunological test, was carried out. 2) A cohort of patients with latent tuberculosis infection with and without HIV infection (Moscow) was studied in the period 2020–2021. to determine the prevalence of latent infection in the close circle of communication of indicator patients. Results. Patients with tuberculosis, forming hidden foci and identified by the indicator patients infected by them with a latent infection, in 56.7% of cases were not examined for tuberculosis for 2–10 years, in 50.0% they suffer from tuberculosis with registered bacterial excretion, in 46.7% of cases are internal or external migrants. The prevalence of latent tuberculosis infection among indicator patients is 10%, which is many times higher than the prevalence of latent tuberculosis infection among the permanent population of Moscow (less than 1%), in HIV-infected risk groups (up to 5%), in known foci of tuberculosis on average in Moscow (5%). The TB notification rate in the environment of indicator patients with latent tuberculosis infection is 38.8 per 100,000 of the corresponding group and exceeds that among the permanent population of Moscow by 5.4 times. Conclusion. A modified epidemiological investigation aimed at examining the environment of persons with latent TB infection among adults makes it possible to identify TB patients who have infected indicator patients and to identify other infected patients.

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Description of the Course of Tuberculosis in the Sources of Infection and Children Who Developed Tuberculosis After Exposure to the Infection for Different Periods of Time

Губкина¹,

Khokhlova²,

Yukhimenko³

et al. 2018

TIBL

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Цель исследования: изучение характеристик туберкулезного процесса у предполагаемых источников инфекции и заболевших детей при различной продолжительности контакта� Методы и материалы: всего 136 бытовых очагов туберкулезной инфекции� Три группы с различным сроком проживания в очаге инфекции до выявления заболевания у ребенка: 1-я группа (33 очага)-продолжительность контакта не более 6 мес�; 2-я группа (67 очагов)продолжительность контакта от 6 мес� до 2 лет; 3-я группа (36 очагов)-продолжительность контакта более 2 лет� Возраст детей от 3 до 14 лет� Источники инфекции (136 чел�)-бактериовыделители с различными результатами теста на лекарственную чувствительность M. tuberculosis (МБТ)� Результаты. У источников инфекции при более длительном сроке заболевания возрастала доля фиброзно-кавернозного туберкулеза и МЛУ/ШЛУ МБТ: 1-я группа-6,1 и 36,4%; 2-я группа-29,8 и 53,7%; 3-я группа-66,1 и 63,9%� Процессы у детей в сравниваемых группах были идентичными� Независимо от длительности контакта в основном выявляли туберкулез внутригрудных лимфатических узлов и очаговый туберкулез легких: 1-я группа-36,4 и 30,3%; 2-я группа-52,2 и 37,3%; 3-я группа-33,3 и 36,1%� Во всех группах отмечалась высокая доля «малых» форм туберкулеза и процессов в фазе уплотнения и/или неполной кальцинации: 1-я группа-45,5 и 51,5%; 2-я группа-82,1 и 76,1%; 3-я группа-69,4 и 63,9%� При обследовании по контакту выявлена большая часть детей 1-й и 2-й групп (81,8 и 80,6%)� В 3-й группе отмечено снижение качества диспансерного наблюдения за контактными лицами, в результате чего при обследовании по контакту заболевание у детей выявлено достоверно реже-в 58% случаев (р 1-3 < 0,03, р 2-3 < 0,02)�

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Prognostic Factors for Tuberculosis Development in Children With Latent Tuberculosus Infection

Cited by 6 publications

References 0 publications

Evaluation of the specificity of an intradermal test with recombinant tuberculosis allergen in Bacillus Calmette–Guérin-vaccinated healthy volunteers

Evaluation of the specificity of an intradermal test with recombinant tuberculosis allergen in Bacillus Calmette–Guérin-vaccinated healthy volunteers

Possibilities of Detecting an Epidemic Focus of Tuberculosis Infection in an Indicator Patient with a Positive Immunological Test for Tuberculosis

Description of the Course of Tuberculosis in the Sources of Infection and Children Who Developed Tuberculosis After Exposure to the Infection for Different Periods of Time

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