Prognostic factors for survival in patients with advanced renal cell carcinoma undergoing nonmyeloablative allogeneic stem cell transplantation

Abstract

Formation of toxic amyloid structures is believed to be associated with various late‐onset neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. The fact that many proteins in addition to those that are associated with clinical conditions have the potential to form amyloid fibrils in vitro provides opportunities for studying the fundamentals of protein aggregation and amyloid formation in model systems. Accordingly, considerable interest and effort has been directed toward developing small molecules to inhibit the formation of fibrillar assemblies and their associated toxicities. In the present study, we investigated the inhibitory effect of crocin and safranal, two principal components of saffron, on fibrillation of apo‐α‐lactalbumin (a‐α‐LA), used as a model protein, under amyloidogenic conditions. In the absence of any ligand, formation of soluble oligomers became evident after 18 h of incubation, followed by subsequent appearance of mature fibrils. Upon incubation with crocin or safranal, while transition phase to monomeric beta structures was not significantly affected, formation of soluble oligomers and following fibrillar assemblies were inhibited. While both safranal and crocin had the ability to bind to hydrophobic patches provided in the intermediate structures, and thereby inhibit protein aggregation, crocin was found more effective, possibly due to its simultaneous hydrophobic and hydrophilic character. Cell viability assay indicated that crocin could diminish toxicity while safranal act in reverse order. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 854–865, 2010.

Reduced-intensity unrelated cord blood transplantation for treatment of metastatic renal cell carcinoma: first evidence of cord-blood-versus-solid-tumor effect

“…However, the worldwide clinical experience of allogeneic SCT for metastatic RCC is limited, with approximately 200 cases reported in the literature. [3][4][5][6][7][8][9][10][11][12][13][14][15]24 One of the major restrictions of this approach is the requirement that transplant candidates have an HLA-identical related donor. This requirement may limit the use of allogeneic stem cell transplantation to a minority of patients with metastatic RCC.…”

“…The results of pilot reduced-intensity transplant trials for metastatic RCC are encouraging and show that responses can occur in patients with advanced metastatic disease that has failed to respond to conventional cytokine-based therapy. 1,[3][4][5][6][7][8][9][10][11][12][13][14][15] Unrelated cord blood (UCB) is considered an alternative hematopoietic stem cell source for transplantation, and its use in adult patients with hematologic disorders is increasing. [16][17][18][19][20][21] Thus far, UCB transfer has not been attempted in patients with a solid-organ malignancy such as RCC.…”

Non-Infectious Early Complications of Allogeneic Stem Cell Transplantations

“…Especially busulfan, fludarabine, platinum-based chemotherapy and total body irradiation are blamed. [71][72][73][74][75][76][77][78][79][80] Various fungal factors, especially Aspergillus, and various viral factors, especially CMV and Adenovirus, may cause endothelial damage by causing an increase in soluble fms-like tyrosine kinase or thrombomodulin, PAI-1, and inflammatory cytokines. 71,81 Other potential infectious causes include parvovirus B19, HHV-6, and, most recently, BK virus.…”

Prognostic Significance of C-reactive Protein in Urological Cancers: a Systematic Review and Meta-analysis

“…A total of 43 eligible studies (7, 490 patients) were identified for this meta-analysis (25 for RCC (Atzpodien et al, 2003;Bromwich et al, 2004;Casamassima et al, 2005;Peccatori et al, 2005;Ito et al, 2006;Lamb et al, 2006;Vogl et al, 2006;Karakiewicz et al, 2007;Komai et al, 2007;Ramsey et al, 2007;Kawata et al, 2008;Ramsey et al, 2008;Tanaka et al, 2008;Iimura et al, 2009;Jagdev et al, 2010;Cho et al, 2011;Falkensammer et al, 2011;Bedke et al, 2012;Fujita et al, 2012;Sim et al, 2012;Steffens et al, 2012;de Martino et al, 2013;Yasuda et al, 2013), 10 for UC (Hilmy et al, 2005;Hilmy et al, 2006;Saito et al, 2007;Yoshida et al, 2008;Gakis et al, 2011;Saito and Kihara, 2011;Ishioka et al, 2012;Obata et al, 2012;Tanaka et al, 2012;Stein et al, 2013), and 8 for PC (McArdle et al, 2006;Beer et al, 2008;Nakashima et al, 2008;McArdle et al, 2010;Pond et al, 2012;Prins et al, ...…”