Prognostic Factors for Severe Coronavirus Disease 2019 in Daegu, Korea

Abstract

Background: Since its first detection in December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 infection has spread rapidly around the world. Although there have been several studies investigating prognostic factors for severe COVID-19, there have been no such studies in Korea. Methods: We performed a retrospective observational study of 110 patients with confirmed COVID-19 hospitalized at a tertiary hospital in Daegu, Korea. Demographic, clinical, laboratory, and outcome data were collected and analyzed. Severe disease was defined as a composite outcome of acute respiratory distress syndrome, intensive care unit care, or death. Results: Diabetes mellitus (odds ratio [OR], 19.15; 95% confidence interval [CI], 1.90-193.42; P = 0.012), body temperature ≥ 37.8°C (OR, 10.91; 95% CI, 1.35-88.36; P = 0.025), peripheral oxygen saturation < 92% (OR, 33.31; 95% CI, 2.45-452.22; P = 0.008), and creatine kinase-MB (CK-MB) > 6.3 (OR, 56.84; 95% CI, 2.64-1,223.78, P = 0.010) at admission were associated with higher risk of severe COVID-19. The likelihood of development of severe COVID-19 increased with an increasing number of prognostic factors. Conclusion: In conclusion, we found that diabetes mellitus, body temperature ≥ 37.8°C, peripheral oxygen saturation < 92%, and CK-MB > 6.3 are independent predictors of severe disease in hospitalized COVID-19 patients. Appropriate assessment of prognostic factors and close monitoring to provide the necessary interventions at the appropriate time in high-risk patients may reduce the case fatality rate of COVID-19.

Dementia and outcomes from coronavirus disease 2019 (COVID-19) pneumonia: A systematic review and meta-analysis

“…A total of 5,332 records were excluded after screening the titles/abstracts because they did not match our inclusion and exclusion criteria. After evaluating 38 full-texts for eligibility, 6 full-text articles were excluded because they do not have the control/comparison group, 5 full-text articles were excluded because they do not have the outcome of interest (risk of COVID-19 infection, severe COVID-19, and mortality), 3 full-text articles were excluded because the articles were not in English, and finally, 24 studies ( Atkins et al, 2020 , Bianchetti et al, 2020 , Covino et al, 2020 , Docherty et al, 2020 , Giorgi Rossi et al, 2020 , Harrison et al, 2020 , Hong et al, 2020 , Hwang et al, 2020 , Jang et al, 2020 , Ji et al, 2020 , Kabarriti et al, 2020 , Knights et al, 2020 , Kokoszka-Bargieł et al, 2020 , Lee et al, 2020 , Miyashita et al, 2020 , Mohamed et al, 2020t , Moon et al, 2020 , Nystad et al, 2020 , Poblador-Plou et al, 2020 , Rozenfeld et al, 2020 , Sapey et al, 2020 , Sung et al, 2020 , Wan et al, 2020 , Yang et al, 2020 ) with a total of 4,648,247 sample size and 46,391 dementia patients were included in the meta-analysis ( Figure 1 ). Of a total of 24 included studies, 21 were retrospective cohort, 2 studies were prospective cohort, while the remaining 1 study was a case-control study.…”

Wnt5a and Wnt11 as acute respiratory distress syndrome biomarkers for severe acute respiratory syndrome coronavirus 2 patients

“…In order to establish reliable diagnostic biomarkers, we have conducted a prior study by exploring clinical manifestations and various risk factors on severe SARS-CoV-2 patients admitted to Yeungnam university medical center in Korea [ 14 , 15 ]. We conducted research to discover new biomarkers in blood based on patient information such as age, BMI, and comorbidities ( fig.…”

Clinical Features of COVID-19 in Uzbekistan

“…Similarly, a study analyzing the characteristics of patients in a university hospital in Daegu, Korea showed the differences of temperature between severe and non-severe group, and high body temperature was found to affect the severity of hospitalized COVID-19 patients. 8 13/17 https://jkms.org https://doi.org/10.3346/jkms.2020. 35.e404…”