Dementia and outcomes from coronavirus disease 2019 (COVID-19) pneumonia: A systematic review and meta-analysis

Hariyanto, Timotius Ivan; Putri, Cynthia; Arisa, Jessie; Situmeang, Rocksy Fransisca V.; Kurniawan, Andree

doi:10.1016/j.archger.2020.104299

Cited by 105 publications

(119 citation statements)

References 46 publications

(33 reference statements)

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“…Our data also confirmed the negative impact of dementia on COVID-19 prognosis ( Covino, De Matteis, et al 2020 ) showing in our cohort an adjusted hazard risk of death in patients with dementia of 2.34. Similarly, in a recent meta-analysis on 56577 patients with COVID-19, dementia whose prevalence was about 10%, was associated with increased mortality in both pooled unadjusted and adjusted effect estimates, with about a two-fold risk of death ( Hariyanto et al 2021 ).…”

Section: Discussionmentioning

confidence: 94%

Predictors of in-hospital mortality AND death RISK STRATIFICATION among COVID-19 PATIENTS aged ≥ 80 YEARs OLD

Covino

Matteis

Polla

et al. 2021

Archives of Gerontology and Geriatrics

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Introduction : To date, mainly due to age-related vulnerability and to coexisting comorbidities, older patients often face a more severe COVID-19. This study aimed to identify at Emergency Department (ED) admission the predictors of in-hospital mortality and suitable scores for death risk stratification among COVID-19 patients ≥ 80 years old. Methods : Single-centre prospective study conducted in the ED of an university hospital, referral center for COVID-19 in central Italy. We included 239 consecutive patients ≥ 80 years old with laboratory-confirmed COVID-19. The primary study endpoint was all-cause in-hospital mortality. Multivariable Cox regression analysis was performed on significant variables at univariate analysis to identify independent risk factor for death. Overall performance in predicting mortality of WHO severity scale, APACHE II score, NEWS score, and CURB-65 was calculated. Results : Median age was 85 [82-89] and 112 were males (46.9%). Globally, 77 patients (32.2%) deceased. The presence of consolidations at chest x-ray and the hypoxemic respiratory failure were significant predictors of poor prognosis. Moreover, age ≥ 85 years, dependency in activities of daily living (ADL), and dementia were risk factors for death, even after adjusting for clinical covariates and disease severity. All the evaluated scores showed a fairly good predictive value in identifying patients who could experience a worse outcome. Conclusions : Among patients ≥ 80 years old hospitalized with COVID-19, not only a worse clinical and radiological presentation of the disease, but also the increasing age, dementia, and impairment in ADL were strong risk factors for in-hospital death, regardless of disease severity.

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Section: Discussionmentioning

confidence: 94%

Predictors of in-hospital mortality AND death RISK STRATIFICATION among COVID-19 PATIENTS aged ≥ 80 YEARs OLD

Covino

Matteis

Polla

et al. 2021

Archives of Gerontology and Geriatrics

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“…People with dementia also face worse health outcomes following COVID-19 exposure, including a nearly 3-fold elevated risk of mortality. 50 Altogether, elderly patients are a subset of the chronic disease population that may face especially amplified fear and difficulty maintaining chronic disease healthcare routines due to the COVID-19 pandemic.…”

Section: Healthcare Characteristics and Utilization By Individuals Wimentioning

confidence: 99%

The Effects of the Health System Response to the COVID-19 Pandemic on Chronic Disease Management: A Narrative Review

Kendzerska¹,

Zhu²,

Gershon³

et al. 2021

RMHP

179

143

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Background Individuals with chronic conditions require ongoing disease management to reduce risks of adverse health outcomes. During the COVID-19 pandemic, health care for non-COVID-19 cases was affected due to the reallocation of resources towards urgent care for COVID-19 patients, resulting in inadequate ongoing care for chronic conditions. Methods A keyword search was conducted in PubMed, Google Scholar, Science Direct, and Scopus for English language articles published between January 2020 and January 2021. Findings During the COVID-19 pandemic, in-person care for individuals with chronic conditions have decreased due to government restriction of elective and non-urgent healthcare visits, greater instilled fear over potential COVID-19 exposure during in-person visits, and higher utilization rates of telemedicine compared to the pre-COVID-19 period. Potential benefits of a virtual-care framework during the pandemic include more effective routine disease monitoring, improved patient satisfaction, and increased treatment compliance and follow-up rates. However, more needs to be done to ensure timely and effective access to telemedicine, particularly for individuals with lower digital literacy. Capitation primary care models have been proposed as a more financially-robust approach during the COVID-19 pandemic than fee-for-service primary care models; however, the interplay between different primary models and the health outcomes is still poorly understood and warrants further investigation. Shortages of medication used to manage chronic conditions were also observed at the beginning of the COVID-19 pandemic due to global supply chain disruptions. Finally, patients with chronic conditions faced lifestyle disruptions due to the COVID-19 pandemic, specifically in physical activity, sleep, stress, and mental health, which need to be better addressed. Interpretation Overall, this review elucidates the disproportionately greater barriers to primary and specialty care that patients with chronic diseases face during the COVID-19 pandemic and emphasizes the urgent need for better chronic disease management strategies moving forward.

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“… 1 , 2 Previously published meta-analysis studies have identified several comorbidities that were associated with severe outcomes from COVID-19, such as obesity, hypertension, diabetes, thyroid disease, dyslipidemia, cardiovascular disease, and pulmonary disease. [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ] Among patients with obesity, one of the most prevalent co-existing comorbid conditions was obstructive sleep apnea (OSA). OSA is the most common sleep-related breathing disorder and is highly prevalent, possibly affecting up to 1 billion people around the world.…”

Section: Introductionmentioning

confidence: 99%

Obstructive sleep apnea (OSA) and outcomes from coronavirus disease 2019 (COVID-19) pneumonia: a systematic review and meta-analysis

Hariyanto

Kurniawan

2021

Sleep Medicine

Self Cite

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Background Obstructive sleep apnea (OSA) is the most prevalent sleep-related breathing disorder which could impair someone's quality of life and is also associated with poor outcomes from many diseases. Currently, the evidence regarding the link between OSA and coronavirus disease 2019 (COVID-19) is still conflicting. This study aims to analyze the relationship between OSA and poor outcomes of COVID-19. Materials and Methods We systematically searched the PubMed and Europe PMC database using specific keywords related to our aims until December 10 th , 2020. All articles published on COVID-19 and OSA were retrieved. The quality of the study was assessed using the Newcastle Ottawa Scale (NOS) tool for observational studies. Statistical analysis was done using Review Manager 5.4 software. Results A total of 21 studies with 54,276 COVID-19 patients were included in this meta-analysis. This meta-analysis showed that OSA was associated with composite poor outcome [OR 1.72 (95% CI 1.55 – 1.91), p < 0.00001, I 2 = 36%, random-effect modelling] and its subgroup which comprised of severe COVID-19 [OR 1.70 (95% CI 1.18 – 2.45), p = 0.005], ICU admissions [OR 1.76 (95% CI 1.51 – 2.05), p < 0.00001], the need for mechanical ventilation [OR 1.67 (95% CI 1.48 – 1.88), p < 0.00001], and mortality [OR 1.74 (95% CI 1.39 – 2.19), p < 0.00001]. Conclusions Extra care and close monitoring should be provided to patients with OSA to minimize the risk of infections. Simple questionnaires such as STOP-Bang questionnaire can be used for screening patients who may be at risk for severe adverse outcomes.

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Dementia and outcomes from coronavirus disease 2019 (COVID-19) pneumonia: A systematic review and meta-analysis

Cited by 105 publications

References 46 publications

Predictors of in-hospital mortality AND death RISK STRATIFICATION among COVID-19 PATIENTS aged ≥ 80 YEARs OLD

Predictors of in-hospital mortality AND death RISK STRATIFICATION among COVID-19 PATIENTS aged ≥ 80 YEARs OLD

The Effects of the Health System Response to the COVID-19 Pandemic on Chronic Disease Management: A Narrative Review

Obstructive sleep apnea (OSA) and outcomes from coronavirus disease 2019 (COVID-19) pneumonia: a systematic review and meta-analysis

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