Prognostic factors for recurrence after conservative treatment in a series of 119 patients with stage I serous borderline tumors of the ovary

The Evaluation of Risk Factors Associated With Relapse and Recurrence of Borderline Ovarian Tumors With Long-Term Follow-up

“…4,14,16,18,20,23Y28 It may be higher in the group managed conservatively and range from 4.9% even to 32% in some reports. 25,26 Our study confirms distinct prognostic outcomes after relapse with borderline versus invasive histology. Relapse with a borderline tumor correlates with conservative surgical treatment, and generally occurs in the ipsilateral or contralateral ovary.…”

Conservative surgery in ovarian borderline tumours: A meta-analysis with emphasis on recurrence risk

“…This led a recent to a recent recommendation that bilateral BOT should be treated with bilateral C and unilateral sBOT treated with C [2][3][4]. Although these major results constitute the only level II of evidence published up to date, the small cohort and discrepancy to this systematic review alert to caution when counselling these women.…”

“…Considering the studies that included only sBOT patients and those studies where recurrence data were provided according to histological subtypes, a total of 433 sBOT patients, enclosing 10 studies [3,[11][12][13][14][15][21][22][23][24], were analysed. The recurrence rate for C, USO and USO + CC were respectively 43.2% (95% CI = 0.349-0.519), 32.1% (95% CI = 0.251-0.400) and 15.3% (95% CI = 0.064-0.320).…”

“…While fertility sparing surgery is widely accepted and performed, there is a lack of randomised controlled trials evaluating its outcome and consequently there is a lack of standardised treatment guidelines. Recent reports have stirred the debate regarding the optimal conservative treatment for women with BOT [2][3][4][5]. The aim of the present study is to examine the optimal oncological approach of fertility sparing surgery in women with unilateral BOT (cystectomy (C) versus unilateral salpingo-oophorectomy (USO)) and in women with bilateral BOT (C + contralateral C (CC) versus USO + CC), as well as fertility outcomes.…”

In Ovo Progression of Borderline Ovarian Tumors

“…Risk factors such as age, histology, and type of surgery (for example fertility sparing surgery); appear to be associated with a higher risk for recurrence. Histologic parameters such as peritoneal implants, microinvasion, and micropapillary pattern do not seem to be associated with a higher recurrence rate [9,10]. Tumor markers, such as CA-125 and CA 19-9 are increased in BOTs, with a higher increase of CA-125 in serous BOT (SBOT) and CA 19-9 in MBOT [11].…”