Prognostic Factors for Clinical Outcomes According to Time after Direct Pulp Capping

Cho, Sin‐Yeon; Seo, Deog-Gyu; Lee, Shin-Jae; Lee, Jung-Hyun; Lee, Seung-Jong; Jung, Ioan

doi:10.1016/j.joen.2012.11.034

Cited by 113 publications

(110 citation statements)

References 25 publications

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“…2,3,4,5 This aggression may be enough to cause impaired regenerative potential and loss of pulp vitality, depending on the previous condition of the pulp tissue. 25,26 Moreover, the loss of progenitor cells during this process has an aging effect that may reduce the regenerative capability of the pulp to withstand future challenges. 6 Therefore, the development of biomaterials that facilitate pulp regeneration of the remaining vital pulp tissues is desired to promote dental pulp self-repair, and regenerate dentin on exposed pulp.…”

Section: Discussionmentioning

confidence: 99%

Chitosan-collagen biomembrane embedded with calcium-aluminate enhances dentinogenic potential of pulp cells

et al. 2016

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The development of biomaterials capable of driving dental pulp stem cell differentiation into odontoblast-like cells able to secrete reparative dentin is the goal of current conservative dentistry. In the present investigation, a biomembrane (BM) composed of a chitosan/collagen matrix embedded with calcium-aluminate microparticles was tested. The BM was produced by mixing collagen gel with a chitosan solution (2:1), and then adding bioactive calcium-aluminate cement as the mineral phase. An inert material (polystyrene) was used as the negative control. Human dental pulp cells were seeded onto the surface of certain materials, and the cytocompatibility was evaluated by cell proliferation and cell morphology, assessed after 1, 7, 14 and 28 days in culture. The odontoblastic differentiation was evaluated by measuring alkaline phosphatase (ALP) activity, total protein production, gene expression of DMP-1/DSPP and mineralized nodule deposition. The pulp cells were able to attach onto the BM surface and spread, displaying a faster proliferative rate at initial periods than that of the control cells. The BM also acted on the cells to induce more intense ALP activity, protein production at 14 days, and higher gene expression of DSPP and DMP-1 at 28 days, leading to the deposition of about five times more mineralized matrix than the cells in the control group. Therefore, the experimental biomembrane induced the differentiation of pulp cells into odontoblast-like cells featuring a highly secretory phenotype. This innovative bioactive material can drive other protocols for dental pulp exposure treatment by inducing the regeneration of dentin tissue mediated by resident cells.

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Section: Discussionmentioning

confidence: 99%

Chitosan-collagen biomembrane embedded with calcium-aluminate enhances dentinogenic potential of pulp cells

et al. 2016

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“…Common strategies for this purpose are pulp capping and pulpotomy, which consist of capping of the exposed living pulp with bioactive materials [3]. Because a capping material comes into contact with the exposed pulp tissues, the bioactivity and biocompatibility of the pulp-capping materials are important factors in determining the treatment outcome [4].…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of a nanoparticulate bioceramic paste for dental pulp repair

et al. 2014

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“…Overall, all available studies show MTA to have excellent biocompatibility (Torabinejad et al 1995b;Pitt Ford et al 1996;Koh et al 1997;Torabinejad & Chivian 1999;Keiser et al 2000) with an exceptional sealing ability against microbial challenges (Torabinejad et al 1993Torabinejad & Chivian 1999). It can be concluded that current research indicates MTA is the preferable material for direct pulp capping and the rational alternative to CH in vital pulp therapy Cho et al 2013) (Fig. 4.5).…”

Section: Physiochemical Propertiesmentioning

confidence: 93%

“…Furthermore, some additives necessary for the hard setting of CH may also be toxic to pulp tissue (Liard-Dumtschin et al 1984). Therefore, MTA has advantages when compared to CH in pulp capping procedures due to better dimensional stability, sustained alkaline pH and equal or improved bioactive properties (Fridland & Rosado 2005;Sarkar et al 2005;Dreger et al 2012;Cho et al 2013). …”

Section: Comparison With Calcium Hydroxidementioning

confidence: 99%

MTA in Vital Pulp Therapy

Dammaschke¹,

Camp

Bogen

2014

Mineral Trioxide Aggregate

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Prognostic Factors for Clinical Outcomes According to Time after Direct Pulp Capping

Cited by 113 publications

References 25 publications

Chitosan-collagen biomembrane embedded with calcium-aluminate enhances dentinogenic potential of pulp cells

Chitosan-collagen biomembrane embedded with calcium-aluminate enhances dentinogenic potential of pulp cells

In vitro and in vivo evaluation of a nanoparticulate bioceramic paste for dental pulp repair

MTA in Vital Pulp Therapy

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