Prognostic factors for amputation in the case of envenoming by snakes of the<i>Bothrops</i>genus (Viperidae)

Jorge, Miguel Tanús; Ribeiro, Lucilene Arilho; O’Connell, João Lucas

doi:10.1080/00034983.1999.11813436

Cited by 35 publications

(32 citation statements)

References 14 publications

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“…A necrose dos tecidos favorece o aparecimento de infecções, com formação de abscessos 19 20 22 . Como a amputação é resultado justamente da ocorrência de necrose e/ou infecção, da mesma forma, não se observou associação da sua ocorrência com a incoagulabilidade sangüínea, o que corrobora dados anteriores 21 . Vale ressaltar, entretanto, que um outro estudo mostrou ocorrência de associação de incoagulabilidade com abscesso 34 .…”

Section: Methodsunclassified

“…A destruição de tecidos e a inoculação de bactérias, juntamente com o veneno, podem levar à infecção e à formação de abscessos 18 20 22 . Distúrbios funcionais permanentes e até mesmo a perda do membro acometido podem ocorrer 21 31 34 42 . O distúrbio da coagulação é, provavelmente, a manifestação sistêmica mais comum que, às vezes, exterioriza-se clinicamente por sangramentos distantes dos ferimentos causados pelos dentes inoculadores 42 .…”

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Fatores associados à incoagulabilidade sangüínea no envenenamento por serpentes do gênero Bothrops

Oliveira

Ribeiro

Jorge

2003

Rev. Soc. Bras. Med. Trop.

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Resumo Com o objetivo de conhecer fatores associados à incoagulabilidade sangüínea no envenenamento botrópico, foram obtidas informações de 2.991 prontuários médicos de pacientes atendidos no Instituto Butantan de 1981 a 1990. Associaram-se positivamente à incoagulabilidade sangüínea (p<0,05): picadas no final do ano e em extremidades dos membros inferiores; dor, edema e equimose local; hemorragia e choque; dose de antiveneno; tempo do acidente à chegada ao Instituto Butantan. Associaram-se negativamente à incoagulabilidade (p<0,05): tamanho de Bothrops jararaca; uso de torniquete; tempo entre a chegada ao Instituto Butantan e o início da administração do antiveneno. Não se associaram à incoagulabilidade (p>0,05): horário do acidente; presença de presa recém-deglutida no tubo digestivo da serpente; sexo e idade do paciente; ocorrência de bolha, necrose, abscesso e incisão local, amputação, insuficiência renal e óbito. Pode-se concluir que, embora a incoagulabilidade sangüínea apresente associação com manifestações precoces do envenenamento, não tem boa associação com a evolução clínica do paciente. Palavras-chaves: Bothrops jararaca. Coagulação sangüínea. Fatores prognósticos.Abstract This study aimed at assessing, in the envenoming by Bothrops, factors that are associated with blood incoagulability. Information was obtained from the charts of 2,991 patients admitted to Instituto Butantan, from 1981 to 1990. Factors positively associated with blood incoagulability (p<0.05) were: snake bite in the late months of the year; bites in the distal segments of the lower limbs; pain, edema, and bruising at the bite site; systemic bleeding and shock; dose of antivenom administered; time between bite and admission to Instituto Butantan. Size of the snake Bothrops jararaca; use of a tourniquet; and time between arrival to Instituto Butantan and start of the antivenom administration were negatively associated with blood incoagulability (p<0,05). Factors not associated with blood incoagulability (p>0.05) were: time of the bite; presence of recently swallowed prey in the snake gut; gender and age of the patient; blister, necrosis, and abscess at the bite site; occurrence of amputation, renal failure and death; presence of an incision at the bite site. We conclude that although blood incoagulability is associated with early manifestations of Bothrops envenoming, it is not associated with the clinical outcome. Key-words: Bothrops jararaca. Blood coagulability. Prognostic factors.

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Section: Methodsunclassified

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Fatores associados à incoagulabilidade sangüínea no envenenamento por serpentes do gênero Bothrops

Oliveira

Ribeiro

Jorge

2003

Rev. Soc. Bras. Med. Trop.

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“…Antivenom administration initiated rapidly after envenomation, can neutralize systemic effects, but neutralization of local tissue damage is a more difficult task. In a number of snake bite cases, lack of neutralization of local effects results in permanent sequelae, with tissue loss (Jorge et al, 1999. In the current study, the effect of a low-level semiconductor GaAs laser on the local pathological alterations induced by B. atrox snake venom was investigated. The effects of low-power lasers are caused by nonthermal mechanisms (King, 1989) produced by light interaction with tissue, resulting in biomodulatory effects through photochemical interactions (Basford, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…The mice were euthanised after 72 h in a CO2 chamber. The gastrocnemius muscles were collected for histological processing, as described previously by Santos-Filho and coworkers (Jorge et al, 1999).…”

Section: Histological Examination Of Myonecrosismentioning

confidence: 99%

INFLUENCE OF A LOW-LEVEL SEMICONDUCTOR GALLIUM ARSENATE LASER IN EXPERIMENTAL ENVENOMATION INDUCED BY <i>BOTHROPS ATROX</i> SNAKE VENOM

Sousa¹

2012

American Journal of Pharmacology and Toxicology

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Bothrops atrox is responsible for the majority of snakebite accidents in Brazilian Amazon and its venom can cause prominent local tissue damage. Experimental groups consisted of five male mice, each administered either ) was administered intramuscularly. The site of venom injection was irradiated by GaAs laser and some animals received antivenom intraperitoneally. GaAs laser irradiation administered in conjunction with antivenom, reduced pain, oedema, inflammation and myonecrosis induced by B. atrox venom in mice. The combined antivenom and GaAs laser treatment was more effective than separately treatments. The results suggest that laser therapy may reduce the local effects induced by B. atrox venom when associated with antivenom.

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“…Venom is a mixture of proteins, lipids, steroids, amino polysaccharides, amines and other compounds which damage various functional systems of the body at the same time. The management of snake bite is a critical problem due to scarcity of Antivenom and adverse reactions ranging from pruritus, urticaria to potential fatal anaphylaxis shocks that develop during treatment 18 . The commercially available polyvalent antivenom neutralizes the systemic effects of venom lethality but fails to nullify the local tissue damage like necrosis which results in permanent sequelae 19 .…”

Section: Discussionmentioning

confidence: 99%

Studies on Efficacy of Medicinal Plants Against the Lethality of Naja Naja Snake Envenomation

N¹,

D²,

M³

et al. 2016

J. Pharm. Sci. Innov.

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Chloroform and aqueous extracts of the selected medicinal plant were evaluated for qualitative phytochemical analysis and inhibiting property of (toxic) lethal factors like PLA2, coagulant activity, proteolytic activity and acetylcholine esterase activity of venom. Many of the extracts under this study exhibited significant inhibitory properties of venom components. (Aqueous and chloroform extracts of Jatropha gossypifolia effectively inhibited the PLA2 activity of Naja naja up to 87 and 85%). Proteolytic activity induced by venom of Naja naja was inhibited up to 63% and 57 % by the aqueous extracts of Antidesma bunius and Sida acuta. Serum coagulation of the venom was inhibited by Commelina bengalensis, Antidesma bunius and many others while Inhibition of acetylcholine esterase was exhibited by chloroform extracts of Antidesma bunius (67%) and aqueous extract of Jatropha gossypifolia (72%) Some of the plants showed promising antivenom potential by inhibiting various in vitro activities of venom. The extracts of Antidesma bunius and Calyopteris floribunda showed good inhibition of venom pathological activities. Further investigation on the identification and characterization of the compounds responsible for the antivenom properties has to be done which can revolutionize the treatment of snake bite.

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Prognostic factors for amputation in the case of envenoming by snakes of theBothropsgenus (Viperidae)

Cited by 35 publications

References 14 publications

Fatores associados à incoagulabilidade sangüínea no envenenamento por serpentes do gênero Bothrops

Fatores associados à incoagulabilidade sangüínea no envenenamento por serpentes do gênero Bothrops

INFLUENCE OF A LOW-LEVEL SEMICONDUCTOR GALLIUM ARSENATE LASER IN EXPERIMENTAL ENVENOMATION INDUCED BY <i>BOTHROPS ATROX</i> SNAKE VENOM

Studies on Efficacy of Medicinal Plants Against the Lethality of Naja Naja Snake Envenomation

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