Prognostic Factors and Survival Analysis of Antimitochondrial Antibody-Positive Primary Biliary Cirrhosis in Chinese Patients

Zhao, Dan-Tong; Liao, Huiyu; Liu, Yanmin; Zhao, Yan; Xia, Feng; Hu, Yan

doi:10.1007/s10620-011-1661-7

Cited by 11 publications

(20 citation statements)

References 31 publications

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“…In PBC patients without AIH features, the risk factors were consistent with published studies [34,41,42], but IgG levels were not considered as risk factors, unlike another study in Chinese patients [43]. For those patients with AIH features, the predictive role of AST was unexpected.…”

Section: Discussionsupporting

confidence: 75%

The Natural History and Prognosis of Primary Biliary Cirrhosis with Clinical Features of Autoimmune Hepatitis

Yang

Wang

et al. 2015

Clinic Rev Allerg Immunol

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Although a variant of primary biliary cirrhosis (PBC) characterized by features of autoimmune hepatitis (AIH) has been recognized for many years, few studies with ample numbers of patients have focused on its natural history. This study aimed to clarify the natural history, prognosis, and response to therapy in a cohort of patients with PBC with AIH features. We retrospectively analyzed 277 PBC patients without AIH features and 46 PBC patients with AIH features seen between September 2004 and April 2014. The 5-year adverse outcome-free survival of PBC patients with AIH features was 58% compared to 81% in PBC patients without AIH features. Multivariate analysis in the patients with AIH features indicated that total bilirubin ≥ 2.70× the upper limit of normal predicted a poor prognosis (p = 0.008, relative risk 8.39, 95% confidence interval (CI) 1.73, 40.73). Combination therapy with ursodeoxycholic acid (UDCA) and immunosuppression provided better short-term responses in PBC patients with AIH features, defined by multiple criteria. Higher aspartate aminotransferase (AST) level at accession suggested better prognosis for PBC patients with AIH features while worse prognosis for PBC patients without AIH features. PBC patients with AIH features differ from those without AIH features in terms of natural history, prognostic indicators, and response to therapy.

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Section: Discussionsupporting

confidence: 75%

The Natural History and Prognosis of Primary Biliary Cirrhosis with Clinical Features of Autoimmune Hepatitis

Yang

Wang

et al. 2015

Clinic Rev Allerg Immunol

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“…However, the predictive role of male sex remains controversial . Furthermore, whether past hepatitis B virus (HBV) infection, which is common in China and other HBV endemic areas, is associated with a poorer prognosis remains uncertain …”

Section: Introductionmentioning

confidence: 99%

Prognosis of 732 ursodeoxycholic acid‐treated patients with primary biliary cholangitis: A single center follow‐up study from China

Chen

Duan

et al. 2018

J of Gastro and Hepatol

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Background and Aim The impact of male sex and past hepatitis B virus (HBV) infection on survival of primary biliary cholangitis (PBC) are issues at discussion. The aim of the present study was to identify risk factors for transplant‐free survival (TRS) in Chinese PBC patients who received ursodeoxycholic acid (UDCA), with special focus on the impact of male sex and past HBV infection. Methods We followed up PBC patients who received UDCA at our institute between January 2000 and December 2017 until their death, liver transplantation, or censored on April 1, 2018, by interview and review of medical records. We used Cox proportional hazards model and Kaplan–Meier method. Results Out of 976 PBC patients, 732 UDCA‐treated patients (female : male = 6.2:1) with required clinical and laboratory data were enrolled in this study. The median follow‐up period were 4.8 years (interquartile range: 2.8–7.1 years). The overall 5‐, 10‐, and 15‐year TRS rates were 86.7% (95% CI: 83.8–88.1), 71.1% (95% CI: 65.0–77.2), and 59.2% (95% CI: 44.5–73.9), respectively. The survival was significantly worse for male patients and older patients (≥ 55 years) (log‐rank test: P < 0.05 for both). On multivariate analysis, male sex, cirrhosis, serum bilirubin, and serum albumin were independent predictors for TRS. There was no significant difference in survivals between patients with (n = 167) and without (n = 219) past HBV infection (log‐rank test: P = 0.293). Conclusions In this large Chinese cohort of UDCA‐treated PBC patients, male sex was associated with shorter survival, whereas past HBV infection was not associated with poorer outcome.

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“…Primary biliary cirrhosis (PBC) is a chronic intrahepatic biliary disease featured by elevated serum alkaline phosphatase (ALP), the presence of antimitochondrial antibody (AMA), and pathological evidence of nonsuppurative destructive cholangitis and destruction of interlobular bile ducts . Although the overall 5‐year survival rate of patients with PBC is about 80–90%, a significant proportion of patients suffer from cirrhosis‐related complications or hepatic malignancies . The clinical course of PBC is typically slow and progressive but differs significantly among individuals.…”

Section: Introductionmentioning

confidence: 99%

New simple prognostic score for primary biliary cirrhosis: Albumin‐bilirubin score

Chan

Wong

et al. 2015

J of Gastro and Hepatol

103

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Prognostic Factors and Survival Analysis of Antimitochondrial Antibody-Positive Primary Biliary Cirrhosis in Chinese Patients

Abstract: Most Chinese PBC patients in this study were symptomatic at diagnosis and had significant mortality. Mayo risk score, and serum IgG were independent prognostic factors for survival.

Cited by 11 publications

References 31 publications

The Natural History and Prognosis of Primary Biliary Cirrhosis with Clinical Features of Autoimmune Hepatitis

The Natural History and Prognosis of Primary Biliary Cirrhosis with Clinical Features of Autoimmune Hepatitis

Prognosis of 732 ursodeoxycholic acid‐treated patients with primary biliary cholangitis: A single center follow‐up study from China

New simple prognostic score for primary biliary cirrhosis: Albumin‐bilirubin score

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