Background and Aims: Globally, lung cancer is the most cause of fatalities for women, followed by breast cancer (BC). Since survival corresponds negatively with the stage of cancer at diagnosis and delayed BC identification leading to high fatality rate. This study aims to evaluate the occurrence of breast malignancy among females in Saudi Arabia (KSA) and Egypt. Also, compare between causes, risk factors of breast cancer and treatment. Methods:cross sectional study was done among females in KSA and Egypt, data was collected from patients in the BC center through interviews. Online questionnaire was distributed to evaluate the prevalence and awareness level of females about BC clinical signs, methods of examination & risk factors of BC. Results: The total participants were 1089 women (546 Saudis and 543 Egyptians), women with BC (5.5% Saudis and 6.7% Egyptians). There was a significance difference among Saudis and Egyptians who are having BC in all demographic characteristics measured. The presence of BC within relatives from the first and second degree, age of menarche, age of menopause, aging, obesity was considered as risk factors of BC. Low level of awareness level about BC was observed. Conclusion: Young and old ages of Saudi and Egyptian females with BC, with relatively little information about it. Effective interventions could improve the implementation of successful programs about prevention, screening, early detection and treatment of BC. Programs for university and high school students should teach breast self-examination techniques.