Prognostic factors and outcomes in Italian patients undergoing curative gastric cancer surgery

Posteraro, Brunella; Persiani, Roberto; Dall’Armi, Valentina; Biondi, Alberto; Arzani, Dario; Sicoli, Federico; Bonassi, Stefano; D’Ugo, Domenico; Ricciardi, Walter; Boccia, Stefania

doi:10.1016/j.ejso.2013.11.002

Cited by 30 publications

(18 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a group of 157 patients with GC who underwent curative surgery in China, H pylori positivity and quantitative PCR were related to N staging, but were not associated with a difference in OS or RFS (15). These findings have been replicated in similar populations (16), as well as in distal gastric cancer (17), stage IV noncardiac gastric cancer (18) and proximal gastric cancer crossing the GEJ (19). There are however some studies that report negative outcomes with H pylori infection.…”

Section: Discussionsupporting

confidence: 52%

Effect of Helicobacter pylori infection on outcomes in resected gastric and gastroesophageal junction cancer

Kolb

Özbek

Harpaz

et al. 2017

J. Gastrointest. Oncol.

View full text Add to dashboard Cite

Background:Helicobacter pylori (H pylori) infection is a known risk factor for gastric cancer (GC) and has been linked with gastroesophageal junction (GEJ) cancer. Studies examining the relationship between H.pylori infection, GC characteristics and prognosis are limited and have yielded conflicting results. We report on the clinicopathologic characteristics and oncologic outcomes of gastric and GEJ cancer patients with and without a history of H. pylori treated at our institution. Results: Ninety-five patients were identified. The majority of patients were male (61%), white (36%) or Asian (34%), with median age at diagnosis 64. Tumors were stage I (51%), stage II (23%), stage III (25%), and stage IV (1%). H pylori infection status was documented at the time of cancer diagnosis in 89 (94%) patients, and following cancer diagnosis and treatment in 6 (6%) patients. Younger age at diagnosis, Asian race and Lauren histologic classification were associated with H Pylori infection. H pylori positive patients exhibited higher 5-year OS and 5-year RFS compared to H pylori negative patients, though the difference was not statistically significant in either univariate or multivariate analyses. Conclusions:In this retrospective series of predominantly early stage GC and GEJ cancers, H. pylori positive patients were significantly younger at cancer diagnosis and were more frequently Asian compared to H. pylori negative patients. Other demographic and histologic classifications except for Lauren histologic classification were similar between the two groups. H pylori positive patients appeared to have improved outcomes compared to H. pylori negative patients.

show abstract

Section: Discussionsupporting

confidence: 52%

Effect of Helicobacter pylori infection on outcomes in resected gastric and gastroesophageal junction cancer

Kolb

Özbek

Harpaz

et al. 2017

J. Gastrointest. Oncol.

View full text Add to dashboard Cite

show abstract

“…Previous studies have investigated the association between cigarette smoking and survival of stomach cancer, but the results have not been consistent. Most studies have demonstrated a null or inverse association of smoking with overall survival . On the other hand, a Japanese study has demonstrated a significant association of ever‐smoking with an increased risk of stomach cancer death .…”

Section: Discussionmentioning

confidence: 99%

“…However, a large‐scale Korean study obtained a conflicting result, that is, a significant association between prediagnosis smoking and better survival . Some studies from Western countries have reported no association . Thus, evidence for the prognostic effect of smoking has been inconsistent.…”

mentioning

confidence: 99%

Associations of cigarette smoking and alcohol drinking with stomach cancer survival: A prospective patient cohort study in Japan

Minami

Kanemura

Oikawa

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

Cigarette smoking and alcohol drinking may affect the prognosis of stomach cancer, but evidence has been inconsistent. We investigated the associations between pretreatment smoking and alcohol drinking and the risk of all-cause and stomach cancer death among 1,576 patients with histologically confirmed stomach cancer diagnosed during 1997-2010 at a single hospital in Japan. Histories of smoking and alcohol drinking were assessed using a self-administered questionnaire. The patients were followed until December 31, 2013. The Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During 9,625.1 person-years, 670 all-cause and 419 stomach cancer deaths were documented. Among the patients overall, ever-drinking was significantly associated with an increased risk of all-cause death (HR: 1.25; 95% CI: 1.03-1.51), but not stomach cancer death. Positive linear associations with the frequency of drinking (p = 0.02) and the amount of alcohol consumed per day (p = 0.03) were observed for the risk of all-cause death. Ever-smoking was not related to either the risk of all-cause or stomach cancer death. Conversely, among the patients who underwent curative resection, a significant positive association was found between ever-smoking and the risk of stomach cancer death (HR: 2.44; 95% CI: 1.17-5.08). A positive association was also found for earlier age at start of smoking (p = 0.0046). Pretreatment smoking and alcohol drinking have significant effects on stomach cancer survival. Lifestyle adjustments throughout life may improve survival.

show abstract

“…The lack of an observed relationship for former smoking may be due to the protective association reported by Park et al [9] however, this study lacked information on cancer stage. There was a modest dose-response relationship observed with increasing smoking exposure from moderate to heavy (moderate n=6 studies [9,58,73,[75][76][77] , HR 1.13, 95% CI 0.81 to 1.58; heavy n=2 studies [75,76], HR 1.97, 95% CI 1.08 to 3.59). Only one study [24] examined the influence of post-diagnosis smoking and reported a worse survival in patients who were smokers compared to those who were non-smokers in the Shanghai Cohort study (HR 1.76, 95% CI 1.11 to 2.79).…”

Section: Gastric Cancer Smoking and Survival In Gastric Cancer Patientsmentioning

confidence: 93%

“…A total of 10 studies [9,24,55,58,61,[73][74][75][76][77][78] which evaluated the influence of smoking on overall survival in gastric cancer patients were identified (Supplementary table 2). Five studies were population-based and smoking exposure was primarily reported for the period prior to cancer diagnosis.…”

Section: Gastric Cancer Smoking and Survival In Gastric Cancer Patientsmentioning

confidence: 99%

Do smoking and alcohol behaviours influence GI cancer survival?

McMenamin

McCain

Kunzmann

2017

Best Practice & Research Clinical Gastroenterology

View full text Add to dashboard Cite

Little is known about the role of alcohol and smoking in GI cancer survival compared to GI cancer development. We systematically reviewed the evidence for a role of smoking and alcohol in prognosis among GI cancer patients and inform whether smoking or alcohol cessation interventions or guidelines for GI cancer patients are likely to improve prognosis. A total of 84 relevant studies were identified. Continued smokers, particularly heavy smokers, had worse prognosis than never smokers in most GI cancers. However, more evidence is needed to establish the likely impact of smoking cessation interventions amongst GI cancer patients. Heavy alcohol drinkers had worse prognosis in oesophageal squamous cell carcinoma and hepatocellular carcinoma patients. Light alcohol consumption was not associated with worse prognosis from any GI cancer, though further studies are needed. UK guidelines for the general population recommending under 14 units (∼7 drinks) per week may be sufficient for GI cancer patients, until further evidence is available.

show abstract

Prognostic factors and outcomes in Italian patients undergoing curative gastric cancer surgery

Cited by 30 publications

References 43 publications

Effect of Helicobacter pylori infection on outcomes in resected gastric and gastroesophageal junction cancer

Effect of Helicobacter pylori infection on outcomes in resected gastric and gastroesophageal junction cancer

Associations of cigarette smoking and alcohol drinking with stomach cancer survival: A prospective patient cohort study in Japan

Do smoking and alcohol behaviours influence GI cancer survival?

Contact Info

Product

Resources

About