Associations of cigarette smoking and alcohol drinking with stomach cancer survival: A prospective patient cohort study in Japan

Minami, Yuko; Kanemura, Seiki; Oikawa, Takuya; Suzuki, Shinichi; Hasegawa, Yasuhiro; Miura, Koh; Nishino, Yoshikazu; Kakugawa, Yoichiro; Fujiya, Tsuneaki

doi:10.1002/ijc.31408

Cited by 24 publications

(24 citation statements)

References 38 publications

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“…Alcohol consumption was reported to increase the occurrence of gastric cancer and lead to a worse prognosis in clinical studies [3]. In this study, we found that alcohol treatment promoted MMP2/7/9/13 expression in both AGS and HGC-27 cells.…”

Section: Discussionsupporting

confidence: 58%

“…A recent study indicated that the global adult alcohol consumption per-capita increased from 5.9 L in 1990 to 6.5 L in 2017, and would increase to 7.6 L by 2030 [27]. Epidemiological studies have found that alcohol was associated with the occurrence and prognosis of gastric cancer [3,4], while the underlying mechanism by which alcohol promotes gastric cancer development remains unclear. In this study, we investigated the role of alcohol in the invasion and proliferation of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The stomach is one of the major target organs of alcohol. Epidemiological studies indicated that alcohol increases both the incidence and mortality of gastric cancer [3,4]. However, the exact effects of alcohol on gastric cancer and the underlying mechanism (s) by which alcohol promotes gastric cancer development are still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Alcohol Consumption Promotes the Invasion and Proliferation of Gastric Cancer

Ding¹,

Wang²,

Kang³

et al. 2019

Journal of Nutritional Oncology

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Objective To determine the effects of alcohol on the invasion and proliferation of gastric cancer. Methods In an in vitro study, gastric cancer cells were treated with different concentrations of alcohol. The protein levels of matrix metalloproteinase (MMP)2/7/9/13, Cyclin D and PCNA were determined by Western blot. The transcription levels of MMP2/7/9/13 were determined by qRT-PCR. An MMPs inhibitor (GM6001) was used to analyze the role of MMPs in the invasion of gastric cancer cells. In an in vivo experiment, the effects of alcohol on the proliferation of gastric cancer was analyzed in a heterotopic transplantation animal tumor model. Results The protein levels of MMP2/7/9/13 were increased in gastric cancer cells (AGS and HGC-27) compared with normal gastric epithelial cells (GES). Alcohol treatment resulted in further elevation of the MMPs expression in the cancer cells and promoted the invasion of the gastric cancer cells. GM6001 inhibited these effects. In addition, alcohol treatment promoted the expression of Cyclin D and PCNA in cancer cells and gastric tumor proliferation in the animal model. Conclusion Alcohol consumption promoted the invasion and proliferation of gastric cancer. Confirmation should be obtained in further studies in additional models.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

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Alcohol Consumption Promotes the Invasion and Proliferation of Gastric Cancer

Ding¹,

Wang²,

Kang³

et al. 2019

Journal of Nutritional Oncology

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“…However, the association between alcohol consumption and GC is still controversial. For instance, some prospective studies have reported an increased risk for GC in alcohol consumers while other studies have reported a lack of association [10–12]. Similarly, meta-analyses studies have reported either an increased risk for GC associated to alcohol consumption or no association [13–15].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population

et al. 2019

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Background Helicobacter pylori infection is recognized as the main risk factor for gastric cancer (GC), the fifth most common neoplasia worldwide. H. pylori interacts with the immune system, disrupting the cytokine network and inducing chronic inflammation. This work aimed to evaluate the association between single nucleotide polymorphisms (SNPs) in selected cytokine gene promoters and GC. Methods The study included 359 subjects, 125 GC patients, 109 intestinal metaplasia (IM) patients and 125 asymptomatic controls. DNA was extracted from white blood cells and nine SNPs in cytokine gene promoters were genotyped using predesigned 5′-endonulease assays. The association of the SNPs with IM and GC was evaluated using multinomial regression models. Results Both genotypes, TC ( OR = 0.51, 95% CI = 0.27–0.98) and TT ( OR = 0.42, 95% CI = 0.20–0.91) in the locus − 509 of the TGF-β promoter were significantly associated with GC. The TT genotype in the locus − 819 of the IL-10 promoter was also significantly associated with GC ( OR = 0.37, 95% CI = 0.17–0.81). No significant association was found with SNPs IL-4 –590 T/C (rs1800629), IL-6 –573G/C (rs1800796), IL-10 –592C/A (rs1800872), IL-10 –1082A/G (rs1800896), and, IFN-γ –1615C/T (rs2069705). Conclusions SNPs in TGFβ (− 509 C/T, rs1800469) and IL-10 (− 819 C/T, rs1800871) promoters were associated with a lower risk for GC in a Mexican population.

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“…If the between-study heterogeneity was moderate to high (I 2 ≥ 50%), the source of heterogeneity was investigated using a sequential algorithm [17]. tional factors [5] and behavioral factors such as cigarette smoking [6] and drinking alcohol [6,7], as well as Helicobacter pylori infection [8], also contribute to the development of stomach cancer. These factors are largely modifiable and preventable, and therefore can be considered when designing effective prevention programs.…”

Section: Sensitivity Analysismentioning

confidence: 99%

Risk factors for stomach cancer: a systematic review and meta-analysis

Moradi²,

et al. 2020

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OBJECTIVES: This report provides information on 14 behavioral and nutritional factors that can be addressed in stomach cancer prevention programs.METHODS: PubMed, Web of Science, and Scopus were searched through December 2018. Reference lists were also screened. Observational studies addressing the associations between stomach cancer and behavioral factors were analyzed. Between-study heterogeneity was investigated using the χ2, τ2, and I2 statistics. The likelihood of publication bias was explored using the Begg and Egger tests and trim-and-fill analysis. Effect sizes were expressed as odds ratios (ORs) with 95% confidence intervals (CIs) using a random-effects model.RESULTS: Of 52,916 identified studies, 232 (including 33,831,063 participants) were eligible. The OR (95% CI) of factors associated with stomach cancer were as follows: Helicobacter pylori infection, 2.56 (95% CI, 2.18 to 3.00); current smoking, 1.61 (95% CI, 1.49 to 1.75); former smoking 1.43 (95% CI, 1.29 to 1.59); current drinking, 1.19 (95% CI, 1.10 to 1.29); former drinking, 1.73 (95% CI, 1.17 to 2.56); overweight/obesity, 0.89 (95% CI, 0.74 to 1.08); sufficient physical activity, 0.83 (95% CI, 0.68 to 1.02); consumption of fruits ≥3 times/wk, 0.48 (95% CI, 0.37 to 0.63); consumption of vegetables ≥3 times/wk, 0.62 (95% CI, 0.49 to 0.79); eating pickled vegetables, 1.28 (95% CI, 1.09 to 1.51); drinking black tea, 1.00 (95% CI, 0.84 to 1.20); drinking green tea, 0.88 (95% CI, 0.80 to 0.97); drinking coffee, 0.99 (95% CI, 0.88 to 1.11); eating fish ≥1 time/wk 0.79 (95% CI, 0.61 to 1.03); eating red meat ≥4 times/wk 1.31 (95% CI, 0.87 to 1.96), and high salt intake 3.78 (95% CI, 1.74 to 5.44) and 1.34 (95% CI, 0.88 to 2.03), based on two different studies.CONCLUSIONS: This meta-analysis provided a clear picture of the behavioral and nutritional factors associated with the development of stomach cancer. These results may be utilized for ranking and prioritizing preventable risk factors to implement effective prevention programs.

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Associations of cigarette smoking and alcohol drinking with stomach cancer survival: A prospective patient cohort study in Japan

Cited by 24 publications

References 38 publications

Alcohol Consumption Promotes the Invasion and Proliferation of Gastric Cancer

Alcohol Consumption Promotes the Invasion and Proliferation of Gastric Cancer

Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population

Risk factors for stomach cancer: a systematic review and meta-analysis

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