Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population

Martínez-Campos, Cecilia; Torres-Poveda, Kirvis; Camorlinga‐Ponce, Margarita; Flores-Luna, Lourdes; Maldonado‐Bernal, Carmen; Madrid‐Marina, Vicente; Torres, Javier

doi:10.1186/s12885-019-5627-z

Cited by 28 publications

(16 citation statements)

References 51 publications

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“…A study by Posada-Sanchez [26] describe frequencies similar to rs1800872 to Mexican residents in Los Angeles (USA) reported in HapMap [25], however, our results for this SNP in the CG are very similar to those reported by Martinez-Campos [27], although all studies agree that the C allele and their corresponding homozygous are the most frequent. This phenomenon has been described in N-ERD genetics studies.…”

Section: Discussionsupporting

confidence: 80%

IL10 rs1800872 Is Associated with Non-Steroidal Anti-Inflammatory Drugs Exacerbated Respiratory Disease in Mexican-Mestizo Patients

et al. 2020

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Non-steroidal anti-inflammatory drugs (NSAID) exacerbated respiratory disease (N-ERD) is a disease integrated by asthma, nasal polyps, and hypersensitivity to non-steroidal anti-inflammatory drugs (NSAID). Genetic association studies have explored single nucleotide polymorphisms (SNPs) in genes involved in theoretical pathophysiological mechanisms, but most of these lack replication of findings in second populations. Our objective was to evaluate the association of SNPs in candidate genomic regions described in Asian and European subjects with N-ERD in Mexican-mestizo patients. We designed a replicative study in two stages. We included 381 SNPs selected by fine mapping of associated genes in a microarray, which were tested in three groups: N-ERD (N), asthma (A), and control group (CG); by means of GoldenGate array, positive results by genetic models were validated in the second stage in another population through qPCR with the same methodology. In the allelic model, we identified 11 SNPs in N vs. CG comparison, and five in N vs. A and A vs. CG, respectively. By genetics models, all SNPs in PPARG, rs13239058 in TBXAS1, and rs1554286 and rs1800872 in IL10 were associated in both models. In the second stage, only rs1800872CC showed an association in the dominant model comparing N vs. GC, p = 0.004, OR = 0.44. In conclusion, rs1800872 in IL10 was the only associated with N-ERD in Mexican-mestizo patients.

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Section: Discussionsupporting

confidence: 80%

IL10 rs1800872 Is Associated with Non-Steroidal Anti-Inflammatory Drugs Exacerbated Respiratory Disease in Mexican-Mestizo Patients

et al. 2020

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“…There are a lot of articles about SNPs of IL-4/IL-13 or their receptors and association with gastric (summary in Supplemental Table S4 [ 45 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 ]) or colorectal (summary in Supplemental Table S5 [ 62 , 137 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 ]) cancer. Some of them revealed certain kinds of SNPs may serve as a risk factor or prognostic marker for each disease [ 150 ].…”

Section: Snps In Il-4/13 and Their Receptors In Gastric And Colon mentioning

confidence: 99%

Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer

Song

Traub

Shi

et al. 2021

IJMS

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Interleukin (IL)-4 and -13 are structurally and functionally related cytokines sharing common receptor subunits. They regulate immune responses and, moreover, are involved in the pathogenesis of a variety of human neoplasms. Three different receptors have been described for IL-4, but only IL-4 receptor type II (IL-4Rα/IL-13Rα1) is expressed in solid tumors. While IL-13 can also bind to three different receptors, IL-13 receptor type I (IL-4Rα/IL-13Rα1/IL-13Rα2) and type II (IL-4Rα/IL-13Rα1) are expressed in solid tumors. After receptor binding, IL-4 and IL-13 can mediate tumor cell proliferation, survival, and metastasis in gastric or colon cancer. This review summarizes the results about the role of IL-4/IL-13 and their receptors in gastric and colon cancer.

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“…BMI ≥24 was used to designate over-weight in Chinese, and rs1532268 TT genotype had poor prognosis in patients with low BMI (BMI<24), while the effect of BMI on gastric cancer is still inconsistent [32][33][34]. H. pylori infection is another important factor in GC risk [35], significant relationship between rs1532268 polymorphism and clinical outcomes was also observed in the patients with H. pylori infection. And for females it also showed worse OS and RFS, who was considered as low gastric cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms in folate-metabolizing genes associated with gastric cancer prognosis in northwest China subjects

et al. 2020

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Influence of folate metabolism has long been studied in cancer and copies evidences have suggested that the key genes involved were correlated with GC risk and prognosis. However, their genetically association and contribution for GC prognosis are still elusive. To evaluate the effect of folate metabolism related genes polymorphisms on the prognosis of gastric cancer (GC), the genotype of seven single nucleotide polymorphisms (SNPs) of three genes were selected and genotyped in a cohort of 664 GC patients, including genes of Methylenetetrahydrofolate reductase (MTHFR), Methionine synthase reductase (MTRR), and Methionine synthase (MTR). Kaplan-Meier Curve, long-rank tests and multivariate Cox proportional hazard model were used for prognosis analysis. The results demonstrated that TT or CT/TT genotypes of SNP rs1532268 in MTRR gene coding region are significantly associated with a poorer overall survival (OS) when compared with CC genotype (HR=2.340, 95% CI: 1.240-4.414, p=0.009; or HR=1.502, 95% CI: 1.083-2.085, p=0.015, respectively). Furthermore, comparing to that of the CC genotype, the detrimental effect of rs1532268 TT genotype was also evident in the special subgroups of GC patients, especially in patients with BMI<24 and H. pylori infection. Moreover, significant association between increased relapse and TT genotype of rs1532268 was also observed in patients who are females, BMI<24 and without chemotherapy. In addition, the joint analysis demonstrated that integration of rs1532268 genotypes and BMI, H. pylori infection status, clinical stage and tumor site may significantly improve the predictive abilities for predicting OS of GC patients. In conclusion, it suggested that the MTRR rs1532268 polymorphism is significantly associated with clinical outcomes of GC patients, especially in those with lower BMI (BMI<24) or positive H. pylori infection status, which warrants further validation. And the polymorphism of MTRR rs1532268 may be a potential prognostic factor for GC patients.

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Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population

Cited by 28 publications

References 51 publications

IL10 rs1800872 Is Associated with Non-Steroidal Anti-Inflammatory Drugs Exacerbated Respiratory Disease in Mexican-Mestizo Patients

IL10 rs1800872 Is Associated with Non-Steroidal Anti-Inflammatory Drugs Exacerbated Respiratory Disease in Mexican-Mestizo Patients

Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer

Genetic polymorphisms in folate-metabolizing genes associated with gastric cancer prognosis in northwest China subjects

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