Prognostic Factors Affecting the Clinical Outcome of Adenoid Cystic Carcinoma of the Head and Neck

Ko, Yoon Ho; Lee, Myung Ah; Hong, Yong-Kil; Lee, Kyung Shik; Jung, Chan Kwon; Kim, Yeon Sil; Sun, Dong‐Il; Kim, Bum Soo; Kim, Min‐Sik; Kang, Jin Hyoung

doi:10.1093/jjco/hym119

Cited by 95 publications

(107 citation statements)

References 26 publications

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“…However, the long-term outcome of these treatments is unfavorable (6). Several studies have identified clinicopathological factors in ACC with an unfavorable effect on survival, including old age, tumor location, advanced stage, solid histological subtype, high grade, tumor-node-metastasis (TNM) staging, major nerve involvement, the presence of perineural invasion, a positive surgical margin and lymph node metastasis (7,8). However, the real prognostic and recurrence factors are still unknown.…”

Section: Introductionmentioning

confidence: 99%

Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma

et al. 2012

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Abstract. The purpose of this study was to explore the factors associated with the recurrence of adenoid cystic carcinomas (ACCs). We examined the recurrence values of clinicopathological variables and GLUT-1, p-Akt and PI3K expression in 42 patients with ACC. Of the 42 patients, 17 developed recurrence following initial surgery. The positive rates of GLUT-1, PI3K and p-Akt protein expression in ACC were 38.1, 38.1 and 50.0%, respectively. The expression of GLUT-1, p-Akt or PI3K protein in ACC was higher than that in inflammatory lesions or benign tumors. Our study demonstrated that T stage, a positive resection margin, perineural invasion, surgery without postoperative radiotherapy and the expression of GLUT-1, PI3K and p-Akt were factors predictive of recurrence by univariate analyses. In multivariate analyses, perineural invasion, a positive resection margin and p-Akt were significant predictors of recurrence. Initial surgery is very significant in the recurrence of ACC. Overexpression of GLUT-1, PI3K and p-Akt may also play a role in its development and recurrence.

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Section: Introductionmentioning

confidence: 99%

Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma

et al. 2012

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“…Consequently, the prognosis of adenoid cystic carcinoma remains clinically unpredictable. 6,7 Furthermore, considerable previous research has linked Ki-67 expression with the aggressiveness and prognosis of adenoid cystic carcinoma, although the results are still perplexing. 8 For these reasons, the research reported here used previously unstudied samples of adenoid cystic carcinoma supplied by the Department of Anatomical Pathology, Dr. Hasan Sadikin Hospital, Bandung.…”

Section: Discussionmentioning

confidence: 99%

“…6 In other words, the prognosis of adenoid cystic carcinoma is clinically unpredictable. 7 Furthermore, a considerable body of research has linked Ki-67 expression with the aggressiveness and prognosis of adenoid cystic carcinoma, although results remain inconclusive. 8 Consequently, it is important to predict the prognosis of the tumor.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Ki-67 expression as clinicopathological parameters in predicting the prognosis of adenoid cystic carcinoma

Kintawati

Darjan

Yohana

2017

Dent. J. (Maj. Ked. Gigi)

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“…The common sites of metastasis are lungs, bone, liver and brain. Metastasis to the spinal vertebrae is extremely rare though perineural invasion in margin positive surgical resections have been noted in literature [3][4][5][6]. Typically, low back or neck pain is the commonest presentation of spinal metatstasis, followed by weakness, sensory loss, and bladder dysfunction [7].…”

Section: Discussionmentioning

confidence: 99%

“…The median time to locoregional recurrence is two years and distant metastasis is three years with a three and five year disease free survival rates being 64.3% and 36.1% respectively [6].…”

Section: Discussionmentioning

confidence: 99%

Extradural Spinal Metastasis of Adenoid Cystic Carcinoma (ACC): A Case Report

Kumar¹

2015

JCDR

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A 45-year-old male presented to the neurosurgery out patient department with diffuse low back pain radiating to the right girdle since two months and inability to walk since two days. The pain was continuous in nature, exaggerated on activity and was persistent during the night with relief on taking analgesics. He had no associated co-morbid illness and or habituations. There was no history of trauma or tuberculosis.Patient gave a past history of primary submandibular gland tumour resection 11 years back followed by radiation therapy. The diagnosis of ACC was rendered on the excised specimen (as per outside histopathology reports). He was advised an FDG-PET (Positron emission testing) scan, however differed the same. Nine years later, he developed a recurrent nodule at the previous scar and was detected to have recurrent disease on fine needle aspiration cytology. He underwent a wide local excision of the lesion with modified radical neck dissection (done at KMC, Manipal). The final histopathology was reported as ACC with negative margins and nodal metastasis (6 out of 12 isolated were positive for metastasis). He deferred palliative radiation therapy and was kept on regular follow-up. examinationOn clinical examination patient had mild spastic gait (Ashworth grade 4) [1] with bilateral lower limb spasticity. Power was 5/5 in both lower limbs. There was sensory loss below L1 level on the right side, and below L3 on the left side with gross involvement of the posterior column with no involvement of bowel or bladder. Bilateral knee and ankle jerk were brisk (3+) [1]. Mouth opening was restricted with Grade II trismus, intraoral examination revealing a densely fibrosed buccal mucosa [2] on the irradiated side. Rest of the oral cavity examination was unremarkable. He had a keloid formation over the operative site. On the outset, with the history of malignancy and an acute progression of lower limb motor function loss, our primary clinical diagnosis was (a) spinal metastasis, second was (b) epidural haematoma with compression over the traversing roots and less likely (c) bleed into a pre-existing meningioma. Adenoid cystic carcinoma (ACC) is a rare malignant tumour of the major salivary glands. It accounts for 10-15% of all salivary gland tumours and 1% of all head and neck tumours. Surgical resection followed by radiation is the choice of treatment for ACC. However, late loco-regional recurrence and metastasis is often seen emphasizing the importance of long-term follow-up.We report an unusual case of extradural metastasis of ACC in the dorsal spine. The primary submandibular gland tumour was resected 11 y back. A recurrence had been detected two years prior to the occurrence of spinal metastasis. Surgical decompression was done which was followed by palliative radiotherapy. Patient is symptomatically better, ambulant and on regular follow-up.Keywords: Adenoid cystic carcinoma, Compressive syndrome, Extradural spinal metastasis, Perineural invasion InvestigationMagnetic resonance imaging (MRI) of the dorso-lumbar sp...

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Prognostic Factors Affecting the Clinical Outcome of Adenoid Cystic Carcinoma of the Head and Neck

Cited by 95 publications

References 26 publications

Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma

Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma

Analysis of Ki-67 expression as clinicopathological parameters in predicting the prognosis of adenoid cystic carcinoma

Extradural Spinal Metastasis of Adenoid Cystic Carcinoma (ACC): A Case Report

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