Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma

Abstract

Abstract. The purpose of this study was to explore the factors associated with the recurrence of adenoid cystic carcinomas (ACCs). We examined the recurrence values of clinicopathological variables and GLUT-1, p-Akt and PI3K expression in 42 patients with ACC. Of the 42 patients, 17 developed recurrence following initial surgery. The positive rates of GLUT-1, PI3K and p-Akt protein expression in ACC were 38.1, 38.1 and 50.0%, respectively. The expression of GLUT-1, p-Akt or PI3K protein in ACC was higher than that in inflammatory lesions or benign tumors. Our study demonstrated that T stage, a positive resection margin, perineural invasion, surgery without postoperative radiotherapy and the expression of GLUT-1, PI3K and p-Akt were factors predictive of recurrence by univariate analyses. In multivariate analyses, perineural invasion, a positive resection margin and p-Akt were significant predictors of recurrence. Initial surgery is very significant in the recurrence of ACC. Overexpression of GLUT-1, PI3K and p-Akt may also play a role in its development and recurrence.

Overexpression of Malic Enzyme 2 Indicates Pathological and Clinical Significance in Oral Squamous Cell Carcinoma

“…Furthermore, a recent study reported that SOX2, Slug and ALDH are overexpressed in human head and neck cancer [30][31][32][33]. Our result indicated that a close association between SOX2, Slug, ALDH1 and ME2.…”

Roles of glucose transporter-1 and the phosphatidylinositol 3-kinase/protein kinase B pathway in cancer radioresistance (Review)

“…Significant correlations between GLUT-1 and PI3K expression (r=0.394, p=0.01), between GLUT-1 and p-Akt expression (r=0.528, P<0.001), and between p-Akt and PI3K expression (r=0.528, P<0.001) were also observed. In this study, a multivariate analysis showed that p-Akt was a significant predictor of recurrence and that GLUT-1 expression was associated with T stage (according to the TNM classification) and distant metastasis of ACC (118). In a ceruminous adenoma of the external auditory canal, it was also shown by immunohistochemistry that tumor cells were positive for GLUT-1, HIF-1, PI3K and p-Akt (119).…”

Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1

“…GLUT-1 overexpression enables the transport of increased levels of glucose to fulfil the high metabolic rate and rapid growth requirements of malignant cells. In our previous study, it was demonstrated that overexpression of GLUT-1 may have a role in the development of recurrence of ACC-2 cells ( 2 ). In addition, GLUT-1 has been suggested as a potential therapeutic target in other types of cancer ( 14 , 15 ).…”