Prognostic factors affecting graft and patient survival in cadaveric and living kidney transplantation

Kim, S. J.; Lee, H. H.; Lee, D. S.; Lee, Kwang‐Woong; Joh, Jae‐Won; Woo, Doo Hyun; Kwon, Ghee Young; Oh, Hayoung; Kim, Y. G.; Huh, Wooseong; Kim, D. J.; Kim, G. S.; Lee, S. K.; Lee, B. B.

doi:10.1016/j.transproceed.2004.08.071

Cited by 12 publications

(17 citation statements)

References 7 publications

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“…In our multivariate analysis of all patients, LD recipients continued to have a survival advantage over the referent DD group, except in the oldest LD category where the results were not significantly different. As expected, both short-and long-term graft survivals for recipients of a younger LD kidney (age [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] was significantly better than the ideal DD. Interestingly, an advantage was also seen for children who received kidneys from LD aged 50-54 yr of age.…”

Section: Resultssupporting

confidence: 56%

“…The one‐yr allograft survival in pediatric recipients for LD and DD in the 1995–2004 North American Pediatric Renal Trials and Collaborative Studies cohorts was reported as 96% and 93%, while the seven‐yr survival was 76% and 65%, respectively. Therefore, recipients of LD transplants appear to have longer short‐ and long‐term allograft survival overall (1–3, 6, 7, 12, 14–26).…”

mentioning

confidence: 99%

“…Many risk factors for long‐term allograft survival have been evaluated in kidney transplant recipients. Immunologic factors include acute and chronic rejection and primary renal disease recurrence, while non‐immunologic factors include donor factors such as age, race, and co‐morbidities and recipient factors such as age and race (1–3, 8, 11, 13, 20, 21, 24, 27–37). With the steady decline in the incidence of AR, non‐immunologic factors become relatively more important determinants of long‐term allograft survival, and patterns of graft survival within donor source groups have emerged.…”

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confidence: 99%

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The relationship of donor source and age on short‐ and long‐term allograft survival in pediatric renal transplantation

Dale-Shall

Smith

McBride³

et al. 2009

Pediatric Transplantation

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Limited pediatric data on allograft survival from advanced aged kidney donors exist. To determine the influence of donor source and age on allograft survival in pediatric renal transplant recipients, we analyzed the OPTN database. Allograft survival for 7291 pediatric renal transplants was evaluated. Up to five yr post-transplantation, graft survival was higher for LD vs. DD recipients. At seven yr, allograft survival was 71% in 18-54 yr-old LD recipients, 59.1% in >or=55 yr-old LD, and 45.1% in >or=50 yr-old DD recipients. An approximate 35% improvement in allograft survival in 18-54 yr-old LD recipients was observed. Multivariate results showed that recipients of LD 35-49 (aRR 0.66, 95% CI 0.55-0.80) and LD 50-54 (aRR 0.65, 95% CI 0.45-0.94) have a graft survival advantage over the ideal DD. In LD >or=55 yr, no improvement in graft survival was observed when compared with the 18-34 yr-old DD. In summary, we observed in a pediatric population, <55 yr-old LD kidneys afford improved long-term allograft survival when compared with DD kidney recipients. Increasing awareness of the long-term graft survival advantage for children receiving an LD kidney, even from older donors, should be a priority.

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Section: Resultssupporting

confidence: 56%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The relationship of donor source and age on short‐ and long‐term allograft survival in pediatric renal transplantation

Dale-Shall

Smith

McBride³

et al. 2009

Pediatric Transplantation

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“…There has been some controversial discussion regarding the best reconstruction method for evaluating CT data in the setting of donor work‐up [22]. For arterial assessment we preferred to view CT images first with a scroll modus in axial and coronal reconstructions (slice thickness, 1 mm).…”

Section: Discussionmentioning

confidence: 99%

Preoperative evaluation of living kidney donors using multirow detector computed tomography: comparison with digital subtraction angiography and intraoperative findings

Hänninen¹,

Denecke²,

Stelter³

et al. 2005

Transplant Int

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Summary To assess the accuracy of multirow detector computed tomography (MDCT) for the evaluation of renal anatomy for preoperative donor assessment in living related kidney transplantation. MDCT‐scans (4‐ and 16‐slice‐CT) of 51 consecutive living kidney donors (age, 51.6 ± 9.7 years; range, 28–68 years) were analysed by three blinded observers and compared with digital subtraction angiography (DSA) and surgery. Contrast‐enhanced MDCT was performed with 1 mm slice thickness reconstruction interval during arterial and venous phases. Supernumerary renal arteries, veins, early branching of vessels and abnormalities of the ureters were documented. The overall accuracy of computed tomography angiography (CTA) for detection and classification of surgically relevant arterial variants was 97% (99/102). The interpretation of 16‐channel MDCT images was correct in all cases (accuracy, 100%), while the four‐channel CTA had three incorrect results regarding the differentiation of early branching vessels from double renal arteries (accuracy, 93%). The overall accuracy of DSA was 91%. Renal vein abnormalities were correctly diagnosed with MDCT in 100% compared with 89% correct findings with DSA. There were three kidneys with incomplete ureter duplication, detected both with MDCT and DSA. MDCT demonstrated superior accuracy compared with non‐selective DSA for the preoperative assessment of renal anatomy in living kidney donors; and for the distinction of supernumerary arteries versus early branching patterns, 16‐channel CTA data were better than those of the four‐channel system.

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“…Já a transfusão de CH, foi forte fator de risco independente de mortalidade, fato concordante com outros estudos realizados em TH adulto92,146 e pediátrico173,174 .A sobrevida global dos pacientes ao longo de 1 ano, 5 anos e 10 anos pó-TH foi, respectivamente, de 87,1%; 81,5% e 80,3% e a sobrevida global dos enxertos foi, respectivamente, de 87,1%; 77,7% e 75,6%, valores compatíveis com resultados obtidos em outros grandes centros33,37 . A análise comparativa entre as curvas de sobrevida de pacientes e enxertos, demonstrou uma menor sobrevida de ambos ao longo de 1, 5 e 10 anos no grupo ACH, em comparação ao grupo BCH, confirmando relatos prévios de que a transfusão de CH aumenta o número de complicações pós-operatórias, bem como, abrevia a sobrevida de pacientes e enxertos92,93,146,147,175 .…”

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Influência da transfusão de concentrado de hemácias na evolução pós-operatória de crianças submetidas a transplante hepático com doador vivo

Gordon¹

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Este trabalho é dedicado: Aos meus pais, Henry e Renata, que me ensinaram a importância do estudo, do respeito e da perseverança, guiando-me e incentivando-me, diariamente, desde a mais tenra infância. Ao meu esposo, José Antônio, por testemunhar as incontáveis horas de sacrifício e dedicação, por zelar pela família e por seu amor incondicional. Aos meus filhos, Mariana e Victor que, apesar do meu cansaço e impaciência frequentes, me compreenderam e me apoiaram até o fim. AGRADECIMENTOS A Deus, pela graça da vida, da saúde, da família, do amparo, da misericórdia, por me guiar nas horas incertas e me fortalecer perante às dificuldades, me fazendo realizar este sonho.

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Prognostic factors affecting graft and patient survival in cadaveric and living kidney transplantation

Cited by 12 publications

References 7 publications

The relationship of donor source and age on short‐ and long‐term allograft survival in pediatric renal transplantation

The relationship of donor source and age on short‐ and long‐term allograft survival in pediatric renal transplantation

Preoperative evaluation of living kidney donors using multirow detector computed tomography: comparison with digital subtraction angiography and intraoperative findings

Influência da transfusão de concentrado de hemácias na evolução pós-operatória de crianças submetidas a transplante hepático com doador vivo

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