Prognostic evaluation of severe sepsis and septic shock: Procalcitonin clearance vs Δ Sequential Organ Failure Assessment

External validation and improvement of LiFe score as a prediction tool in critically ill cirrhosis patients

“…Furthermore, the SOFA score has been validated to predict mortality better than other scoring systems, with potentially better prediction at 48 h after admission . Our findings were consistent with results reported previously, which showed that the SOFA score was highly correlated with outcome . Although the LiFe score concentration at admission was a prominent predictor of ICU mortality in the MIMIC‐III datasets, the AUC for predicting ICU mortality was lower than the SOFA score (AUC 0.708 vs. 0.762, respectively), as shown in a previous report .…”

Diagnosing and Managing Sepsis by Probing the Host Response to Infection: Advances, Opportunities, and Challenges

“…PCT may play an additional role as a prognostic marker in patients with sepsis. While a single PCT value at presentation has not shown substantial prognostic value (34), multiple studies have demonstrated that PCT can aid in assessing the risk of mortality when measured serially (35)(36)(37). PCT has received FDA clearance for assessing the risk of progression to severe sepsis and septic shock in the critically ill and assessing 28-day all-cause mortality for patients diagnosed with severe sepsis or septic shock, when measured serially over several days.…”

Ang-2, Tie-2, and Ang-2/Tie-2 ratio serum levels as diagnostic and prognostic biomarkers of sepsis in critically ill patients

“…The combination of several biomarkers may reduce the limitations of sensitivity and specificity inherent in the use of single biomarkers and this is the main reason the current study investigated the roles of Ang-2 and Tie-2, without the aim of making direct comparisons of different markers [8,12,36].…”