Prognostic effect of the new 5-factor modified frailty index in patients undergoing carotid endarterectomy with regional anesthesia – A prospective cohort study

Araújo-Andrade, Leonardo; Rocha‐Neves, João; Gamas, Luís; Ribeiro, Hugo; Pereira-Macedo, Juliana; Dias-Neto, Marina; Teixeira, José Fernando; Andrade, José

doi:10.1016/j.ijsu.2020.05.074

Cited by 19 publications

(4 citation statements)

References 41 publications

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“…In predicting poor postoperative prognosis the MFI-5 has been validated and shown to have signi cant agreement with the MFI-11 in the context of upper orthopaedics and multiorgan resections [9][10][11][12][13]. Early identi cation of frail patients and early intervention for diagnosis and treatment are in line with the theory of perioperative applications to enhance postoperative recovery [14,15].…”

Section: Introductionmentioning

confidence: 81%

Application of MFI-5 assessment in severe complications and unfavourable outcomes after radical resection of colorectal cancer

Huang

et al. 2023

Preprint

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BACKGROUND/OBJECTIVE Frailty " is a hallmark of physiologic decline of multiple organ systems and places elderly colorectal cancer patients at increased risk for poor prognosis. While 11 modified frailty indices (MFI-11) have been shown to predict adverse outcomes after radical resection of colorectal cancer, 5 modified frailty indices (MFI-5) have not been studied in this population. Methods Retrospective analysis of patients over 65 years of age who underwent radical resection of colorectal cancer. The MFI-5 score was calculated for each patient, and an MFI-5 score ≥ 2 was defined as frailty. Univariate and multivariate analyses the MFI-5 were performed to determine the value of adverse outcomes and complications after surgery. Results The incidence of serious postoperative complications (53% vs. 30%; P = 0.001) and length of hospital stay [19.00 (15.00-24.50) vs. 17.00 (14.00–20.00); P < 0.05] were significantly prolonged in patients with a MFI5 score ≥ 2. MFI-5 score greater than 2 was an independent risk factor for severe postoperative complications (odds ratio 2.297; 95% confidence interval 1.216 to 4.339; P = 0.01) and an MFI-5 score predicted severe postoperative complications with an area under the ROC curve of 0.629 (95% confidence interval 0.551 to 0.707; P < 0.05). Conclusion The MFI-5 is a sensitive tool for predicting serious complications, prolonged hospital stay, and mortality after radical resection of colorectal carcinoma. The MFI-5 is a practical clinical assessment tool for identifying high-risk patients and supporting preoperative optimization.

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Section: Introductionmentioning

confidence: 81%

Application of MFI-5 assessment in severe complications and unfavourable outcomes after radical resection of colorectal cancer

Huang

et al. 2023

Preprint

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“…Dependent functional status was more prevalent in deceased patients and was an independent predictor of postoperative MI. Prior studies have proven that patients not independent in activities of daily living have a higher incidence of comorbid disease and exhibit more often malnutrition and cognitive dysfunction [26, 27]. Furthermore, evidence shows that these patients have a greater mortality rate when compared with functionally independent individuals [26, 27].…”

Section: Discussionmentioning

confidence: 99%

“…Prior studies have proven that patients not independent in activities of daily living have a higher incidence of comorbid disease and exhibit more often malnutrition and cognitive dysfunction [26, 27]. Furthermore, evidence shows that these patients have a greater mortality rate when compared with functionally independent individuals [26, 27]. As such, preoperative dependent functional status could be used as an indicator of adverse outcomes following surgical interventions.…”

Section: Discussionmentioning

confidence: 99%

Red Blood Cell Distribution Width Predicts Myocardial Infarction and Mortality After Vascular Surgery–A Prospective Cohort Study

et al. 2022

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“…Patients with frailty were divided into high and low groups according to the cut-off values of MFI-5 in previous studies. 13,14 A high MFI-5 score was defined as ≥3.…”

Section: Patientsmentioning

confidence: 99%

The 5‐factor modified frailty index is a novel predictive marker of death from other diseases after curative gastrectomy for gastric cancer

Maeda,

Eto,

Yoshida

et al. 2023

Geriatrics Gerontology Int

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AimThe 5‐factor modified frailty index (MFI‐5) is a stratification tool to evaluate a patient's frailty. This study determined whether the MFI‐5 is associated with short‐ and long‐term outcomes after curative gastrectomy in patients with gastric cancer.MethodsWe retrospectively reviewed 447 consecutive patients who underwent curative gastrectomy, and evaluated their overall survival (OS), relapse‐free survival (RFS) and cancer‐specific survival.ResultsA total of 75 patients (16.8%) had high MFI‐5 scores (MFI‐5 ≥3). A high MFI‐5 score was significantly associated with advanced age, male sex and severe postoperative complications. Patients with high MFI‐5 scores had significantly poorer OS and RFS than those with low MFI‐5 scores (5‐year OS, 80.3% vs 59.7%, P < 0.01; 5‐year RFS, 77.4% vs 54.9%, P < 0.01). Additionally, a high MFI‐5 score was an independent predictor for OS (hazard ratio 1.69, 95% CI 1.09–2.61; P = 0.02) and RFS (hazard ratio, 1.80, 95% CI 1.19–2.74; P = 0.01). However, cancer‐specific survival was not significantly different between the two groups.ConclusionsThe MFI‐5 score can be predictive of postoperative morbidity and deaths from other disease after curative gastrectomy after curative gastrectomy for gastric cancer. Geriatr Gerontol Int 2023; ••: ••–••.

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Prognostic effect of the new 5-factor modified frailty index in patients undergoing carotid endarterectomy with regional anesthesia – A prospective cohort study

Cited by 19 publications

References 41 publications

Application of MFI-5 assessment in severe complications and unfavourable outcomes after radical resection of colorectal cancer

Application of MFI-5 assessment in severe complications and unfavourable outcomes after radical resection of colorectal cancer

Red Blood Cell Distribution Width Predicts Myocardial Infarction and Mortality After Vascular Surgery–A Prospective Cohort Study

The 5‐factor modified frailty index is a novel predictive marker of death from other diseases after curative gastrectomy for gastric cancer

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