Prognostic comparison between peripheral and central types of squamous cell carcinoma of the lung in patients undergoing surgical resection.

Mizushima, Yutaka; Yamashita, Ryohei; Kusajima, Yoshinori; Sugiyama, Soichi

doi:10.3892/or.7.2.319

Cited by 14 publications

(12 citation statements)

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“…Overall 5-year survival remains very poor for lung cancer, and there is little difference in 5-year survival rates between patients with central and peripheral tumors (56,57). At the same time, survival is better for early-stage tumors which are V3 cm compared with >3 cm in diameter (58), and 35% of peripheral tumors in our study were V3 cm compared with 14% of tumors in a central location.…”

Section: Discussionmentioning

confidence: 51%

Influence of Type of Cigarette on Peripheral versus Central Lung Cancer

Brooks

Austin

Heelan

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Objectives: Adenocarcinoma has replaced squamous cell carcinoma as the most common cell type of lung cancer in the United States. It has been proposed that this shift is due to the increased use of filter and lower-tar cigarettes, resulting in increased delivery of smoke to peripheral regions of the lungs, where adenocarcinoma usually occurs. We reviewed radiologic data to evaluate the hypothesis that tumors in smokers of cigarettes with lower-tar yield are more likely to occur peripherally than tumors in smokers of higher-yield cigarettes. Methods: At two urban academic medical centers, we reviewed computed tomographic scans, chest radiographs, and medical records to assign tumor location (peripheral or central) for 330 smokers diagnosed with carcinoma of the lung between 1993 and 1999. We compared the proportion of tumors in a peripheral versus central location by lifetime filter use and average lifetime tar rating (<21 and z z z21 mg). Results: Tumor location (69% peripheral and 31% central) was unrelated to cigarette filter use. Smokers of cigarettes with lower-tar ratings were more likely than those with higher ratings to have peripheral rather than central tumors (odds ratio, 1.76; 95% confidence interval, 0.89-3.47). When restricted to subjects with adenocarcinoma or squamous cell carcinoma, the odds ratio (95% confidence interval) was 2.31 (1.05-5.08).

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Section: Discussionmentioning

confidence: 51%

Influence of Type of Cigarette on Peripheral versus Central Lung Cancer

Brooks

Austin

Heelan

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…31 The 3-type classification is not common but our figure for the central type, 31%, appears slightly lower than that reported by others, 41-47%. 5,7,30,32 The percentages of smokers in the examined cases were high (male 91% and female 60%), compared with 48.3 and 13.6%, respectively, in the Japanese general population, 33 in line with the fact that SCC of the lung is strongly associated with smoking. Funai et al (2003) reported similar rates for central and peripheral types, 30 and with division into only these 2 categories, we also found no significant difference.…”

Section: Discussionmentioning

confidence: 71%

p53 mutation spectra for squamous cell carcinomas at different levels of human bronchial branches

Shimmyo

Hashimoto

Kobayashi

et al. 2006

Intl Journal of Cancer

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The question of whether squamous cell carcinomas (SCCs) arising in different sites of lung are caused by different etiological factors is of obvious importance for prevention, early detection and effective treatment. We here subclassified a large series of resected SCCs (74 cases) into 3 tumor-sites, central (main to segmental bronchi), intermediate (subsegmental to sub-subsegmental) and peripheral (distal to sub-subsegmental bronchi), and examined relationships with p53 mutational spectra and smoking history to provide clues to etiological factors. The rate for GfiA transitions at CpG sites considered to be caused by endogenous mechanism was higher in central (40%) than in intermediate (0%) and peripheral (14%) lesions, in spite of highest percentage of heavy smokers. In contrast, GfiT transversions associated with tobacco smoke carcinogens were most frequent (50%) in the intermediate location, although proportions of heavy smoker's ratio were the same among the locations when confined to p53 mutation cases. In the periphery, other mutations were highest (67%) compared with 33 and 50% in the central and intermediate regions, respectively. Thus, different etiological factors may be playing causal roles in the development of SCCs in different locations of bronchial tree. Furthermore, the results suggest that more extensive study of the influence of tobacco smoke carcinogens on endogenous mechanisms is warranted.

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“…Association with consolidative obstructive pneumonias may result in "false" measurements of tumor diameter when they obscure the gross determination of tumor size, thereby affecting T1/T2 designation. One aspect of the histologic evaluation of squamous carcinoma that has been noted to resemble lepidic growth of adenocarcinoma is the ability of squamous cell carcinomas to grow on alveolar basement membranes and within alveolar spaces in a nondestructive fashion by solid cohesive aggregates of neoplastic squamous epithelium [13][14][15][16][17][18][19][20][21]. This pattern of growth could confound the adequacy of size-based T staging for squamous carcinomas as it has for small adenocarcinomas of the lung [22,23].…”

Section: Introductionmentioning

confidence: 99%

Peripheral squamous cell carcinoma of lung: patterns of growth with particular focus on airspace filling

Yousem

2009

Human Pathology

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Prognostic comparison between peripheral and central types of squamous cell carcinoma of the lung in patients undergoing surgical resection.

Cited by 14 publications

References 0 publications

Influence of Type of Cigarette on Peripheral versus Central Lung Cancer

Influence of Type of Cigarette on Peripheral versus Central Lung Cancer

p53 mutation spectra for squamous cell carcinomas at different levels of human bronchial branches

Peripheral squamous cell carcinoma of lung: patterns of growth with particular focus on airspace filling

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