Prognostic and clinicopathological significance of long noncoding RNA MALAT-1 expression in patients with non-small cell lung cancer: A meta-analysis

Liu, Xiaoli; Huang, Guichuan; Zhang, Jing; Zhang, Longju; Liang, Zongan

doi:10.1371/journal.pone.0240321

Cited by 9 publications

(6 citation statements)

References 31 publications

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“…26 A meta-analysis of patients with non-small-cell lung cancer showed that high expression of MALAT-1 in tumor tissues was associated with shorter overall survival. 27 Similarly, the role of MALAT-1 in a variety of autoimmune diseases should not be ignored. MALAT-1 inhibited the inflammatory response of articular chondrocytes induced by IL-1β by blocking the activation of the JNK signaling pathway, enhancing chondrocyte proliferation, and inhibiting chondrocyte apoptosis and extracellular matrix degradation.…”

Section: Discussionmentioning

confidence: 99%

Association of MALAT-1 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus

Mao

et al. 2021

Lupus

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Background: Abnormal expression and function of long non-coding RNAs (lncRNAs) are closely related to the pathogenesis of systemic lupus erythematosus (SLE). In this study, we aimed to investigate the association of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) gene single-nucleotide polymorphisms (SNPs) with susceptibility and clinical characteristics of SLE patients. Methods: A case-control study including 489 SLE patients and 492 healthy controls was conducted. Four MALAT-1 SNPs (rs4102217, rs591291, rs11227209, and rs619586) were genotyped in all subjects, their correlation with SLE susceptibility and clinical characteristics were also analyzed. Results: Results showed that the rs4102217 locus was associated with the risk of SLE. In recessive models, the GG+CG genotype of rs4102217 was associated with the decreased risk of SLE compared to CC ( p = 0.036, OR = 0.348, 95% CI: 0.124–0.975). In additive models, the GG genotype of rs4102217 was associated with the decreased risk of SLE compared to CC ( p = 0.040, OR = 0.355, 95% CI: 0.127–0.996). However, no association was found between MALAT-1 gene polymorphism and clinical manifestations of SLE (all p > 0.05). Conclusion: In summary, MALAT-1 rs4102217 is associated with susceptibility to SLE, suggesting that MALAT-1 may play a role in SLE.

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Section: Discussionmentioning

confidence: 99%

Association of MALAT-1 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus

Mao

et al. 2021

Lupus

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“…It is highly important that MALAT1 expression was not detected in 73.4% of plasma samples after DNAse treatment. Τhis observation, combined with the lack of DNAse treatment, may explain the ambiguous results of various studies that characterized MALAT1 either as oncogene or as tumor suppressor and consequently report that its expression is upregulated or downregulated, respectively [ 21 , 30 , 49 , 50 ]. One of the few studies that performed DNAse treatment before quantification of MALAT1 expression demonstrated that MALAT1 is a metastasis-suppressing lncRNA rather than a metastasis promoter lncRNA in breast cancer [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Genomic DNA Contamination on the Detection of Circulating Long Non-Coding RNAs: The Paradigm of MALAT1

et al. 2021

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The presence of contaminating gDNA in RNA preparations is a frequent cause of false positives in RT-PCR-based analysis. However, in some cases, this cannot be avoided, especially when there are no exons–intron junctions in the lncRNA sequences. Due to the lack of exons in few of long noncoding RNAs (lncRNAs) and the lack of DNAse treatment step in most studies reported so far, serious questions are raised about the specificity of lncRNA detection and the potential of reporting false-positive results. We hypothesized that minute amounts of gDNA usually co-extracted with RNA could give false-positive signals since primers would specifically bind to gDNA due to the lack of junction. In the current study, we evaluated the effect of gDNA and other forms of DNA like extrachromosomal circular DNAs (eccDNAs) contamination and the importance of including a DNAse treatment step on lncRNAsexpression.As a model, we have chosen as one of the most widely studied lncRNAs in cancer namely MALAT1, which lacks exons. When we tested this hypothesis in plasma and primary tissue samples from NSCLC patients, our findings clearly indicated that results on MALAT1 expression are highly affected by the presence of DNA contamination and that the DNAse treatment step is absolutely necessary to avoid false positive results.

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“…overexpression of lncRNA-MALAT1 in the serum exosomes of NSCLC patients was positively correlated with the tumor stage and lymph node metastasis (32). Moreover, knockdown of lncRNA-MALAT1 suppressed the progression of NSCLC by inhibiting growth and metastasis and facilitating apoptosis, possibly by upregulating miR-185-5p and decreasing the expression of MDM4 in NSCLC (33).…”

Section: Any Additional Considerations If Applicable N/amentioning

confidence: 91%

Research progress regarding long-chain non-coding RNA in lung cancer: a narrative review

Yu¹,

He²,

Lu³

et al. 2022

J Thorac Dis

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Background and Objective: Lung cancer is the main cause of cancer-related death worldwide, and its incidence rate is high. Traditional methods of lung cancer screening, such as those based on X-ray, lowdose computed tomography (LDCT), positron emission computed tomography (PET/CT), electronic bronchoscopy, and serum tumor markers were not satisfied with the urgent need in improving the patient survival rate. Thus, biomarkers for early diagnosis and prognosis of lung cancer are extremely needed.Studies have identified a variety of long-chain non-coding RNAs (lncRNAs) that are expressed at abnormal levels in patients with lung cancer which was believed as a potential biomarker for the diagnosis and prognostic evaluation of lung cancer. This review aims to discuss the role of lncRNAs in non-small cell lung cancer (NSCLC), so as to provide insights into the prognosis of lung cancer. Methods:We searched PubMed database of the related scientific researches with outcomes from 09/16/2011 to 05/02/2022 focusing on lncRNA application in lung cancer via searching terms of "lncRNA AND lung cancer", "lncRNA AND non-small cell lung cancer", "lncRNA AND drug resistance", "lncRNA AND radio sensitivity". Published articles written in English available to readers were considered.

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Prognostic and clinicopathological significance of long noncoding RNA MALAT-1 expression in patients with non-small cell lung cancer: A meta-analysis

Cited by 9 publications

References 31 publications

Association of MALAT-1 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus

Association of MALAT-1 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus

The Effect of Genomic DNA Contamination on the Detection of Circulating Long Non-Coding RNAs: The Paradigm of MALAT1

Research progress regarding long-chain non-coding RNA in lung cancer: a narrative review

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