Association of MALAT-1 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus

Mao, Yan-Mei; He, Yisheng; Wu, Guo-Cui; Hu, Yun; Xiang, Kun; Liao, Tao; Yan, Yu-Lu; Yang, Xiao‐Ke; Shuai, Zongwen; Wang, Guihong; Pan, Hai‐Feng; Ye, Dong‐Qing

doi:10.1177/09612033211040366

Cited by 10 publications

(6 citation statements)

References 31 publications

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“…On the other hand, MALAT1 is the key regulatory factor in the pathogenesis of SLE due to it exerting detrimental effects through the regulation of SIRT1 signaling [14]. The MALAT1 rs4102217 polymorphism is associated with susceptibility to SLE in humans [24]. The characteristics of CASC2 and MALAT1 suggest that they may affect the phenotype (i.e., histological class) of lupus nephritis.…”

Section: Discussionmentioning

confidence: 99%

Urinary Long Non-Coding RNA Levels as Biomarkers of Lupus Nephritis

Szeto

Poon

et al. 2023

IJMS

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Background: Emerging evidence suggests that long non-coding RNA (lncRNA) plays important roles in the regulation of gene expression. We determine the role of using urinary lncRNA as a non-invasive biomarker for lupus nephritis. Method: We studied three cohorts of lupus nephritis patients (31, 78, and 12 patients, respectively) and controls (6, 7, and 24 subjects, respectively). The urinary sediment levels of specific lncRNA targets were studied using real-time quantitative polymerase chain reactions. Results: The severity of proteinuria inversely correlated with urinary maternally expressed gene 3 (MEG3) (r = −0.423, p = 0.018) and ANRIL levels (r = −0.483, p = 0.008). Urinary MEG3 level also inversely correlated with the SLEDAI score (r = −0.383, p = 0.034). Urinary cancer susceptibility candidate 2 (CASC2) levels were significantly different between histological classes of nephritis (p = 0.026) and patients with pure class V nephritis probably had the highest levels, while urinary metastasis-associated lung carcinoma transcript 1 (MALAT1) level significantly correlated with the histological activity index (r = −0.321, p = 0.004). Urinary taurine-upregulated gene 1 (TUG1) level was significantly lower in pure class V lupus nephritis than primary membranous nephropathy (p = 0.003) and minimal change nephropathy (p = 0.04), and urinary TUG1 level correlated with eGFR in class V lupus nephritis (r = 0.706, p = 0.01). Conclusions: We identified certain urinary lncRNA targets that may help the identification of lupus nephritis and predict the histological class of nephritis. Our findings indicate that urinary lncRNA levels may be developed as biomarkers for lupus nephritis.

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Section: Discussionmentioning

confidence: 99%

Urinary Long Non-Coding RNA Levels as Biomarkers of Lupus Nephritis

Szeto

Poon

et al. 2023

IJMS

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“…Metastasis‐associated lung adenocarcinoma transcript1 (MALAT‐1) is upregulated in several cancer cell types and promotes tumour growth and metastasis 60,61 . Mao et al found that MALAT‐1 gene polymorphisms rs4102217 locus was associated with the risk of SLE 62 . Although there are inconsistent findings regarding altered MALAT1 expression in SLE patients, a pathophysiological role for this lncRNA has been noted.…”

Section: Lncrnas In Peripheral Blood and Bone Marrow Samples From Slementioning

confidence: 99%

“…60,61 Mao et al found that MALAT-1 gene polymorphisms rs4102217 locus was associated with the risk of SLE. 62 Although there are inconsistent findings regarding altered MALAT1 expression in SLE patients, a pathophysiological role for this lncRNA has been noted. Yang et al demonstrated that MALAT-1 expression was aberrantly increased in PBMCs of SLE patients and predominantly expressed in human monocytes.…”

Section: Malat-1mentioning

confidence: 99%

Long non‐coding RNAs in systemic lupus erythematosus: New insights into disease pathogenesis and diagnosis

Chen

Cheng

et al. 2022

Scand J Immunol

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Systemic lupus erythematosus (SLE) is a remarkable heterogeneous autoimmune disease that is sometimes hard to diagnose at the early stage and can lead to premature mortality. Long non‐coding RNAs (lncRNAs) are a class of non‐protein‐coding RNAs greater than 200 nucleotides in length that can regulate gene expression in various human diseases, including SLE. Peripheral blood samples and renal tissue samples from SLE patients were used for study. Abnormally expressed lncRNAs in SLE have been shown to influence several signalling pathways, including the IFN‐I, MAPK and WNT pathways. This can affect cellular phenotypes like cell activation, differentiation skewing, cytokine production and cell apoptosis. Many of the reported lncRNAs may be useful for diagnosing, evaluating progression and predicting potential organ damage in SLE patients. While numerous lncRNAs play important roles in SLE, more basic and clinical studies are warranted to clarify the function of these regulatory molecules and determine their diagnostic value.

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“…MALAT1 has been demonstrated in cancers of breast, cervix, gallbladder, lung, ovary, pancreas, prostate, glioma, hepatocellular carcinoma and multiple myeloma [12]. There are also isolated studies on the role of long non-coding RNA Malat1 in the development of pathology of vessels, including lupus erythematosus [13], coronary artery disease [14] and the development of atherosclerosis, which is a predictor of stroke. It is reported that MALAT1 involved in the protection of cerebral microvessels after ischemic insult from a RNA sequencing study.…”

Section: Table 1 -Anthropometric Indicators In Persons Of Different S...mentioning

confidence: 99%

Association Between Malat1 Rs4102217-Polymorphic Variant and Ishemic Atherothrombotic Stroke Development in People With Increased Body Mass Index

Moiseіenko

Harbuzova

Obukhova

2022

EUMJ

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Background. The recent discovery of a group of mediators known as long non-coding RNAs (lncRNAs) is the basis for research that will reduce the risk of cardiovascular disease in the long run. lncRNAs are expressed depending on conditions, and there is ample evidence of their involvement in a variety of biological processes. Indeed, lncRNA abnormalities are directly related to human diseases, including cardiovascular pathology and other diseases. LncRNA MALAT1 is one of the numerous factors causing functional changes in ischemic atherothrombotic stroke (IATS), in particular, it affects the functioning of endothelial cells and is involved in the implementation of inflammatory processes and regulation of autophagy. All those conditions play a role in the development of atherosclerosis, which underlies the pathogenesis of IATS. The effects of rs4102217-polimorphism of MALAT1 on IATS were poorly explored. This research aimed to find out, whether MALAT1 was associated with the susceptibility to IATS in patients with overweight. Materials and Methods. A total of 200 ischemic atherothrombotic stroke patients and 234 controls without acute cardiovascular pathology were enrolled in this study. The rs4102217-polymorphisms in the promoter of MALAT1 were genotyped by using Real-Time PCR. Calculations were made using Statistical Package for the Social Sciences software (SPSS, version 17.0). A value of P ˂ 0.05 was considered as statistically significant. Results. The SNP rs4102217 in the promoter of MALAT1 was associated with the risk of ischemic atherothrombotic stroke in people with increased body mass index (BMI ≥ 25 kg/m2) (Dominant model: adjusted OR = 1.66, 95% CI, 1,024–2,700, P = 0.040) Conclusions. The results showed that c-carriers with elevated BMI were 1.66 times more likely to develop ischemic atherothrombotic stroke.

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Association of MALAT-1 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus

Cited by 10 publications

References 31 publications

Urinary Long Non-Coding RNA Levels as Biomarkers of Lupus Nephritis

Urinary Long Non-Coding RNA Levels as Biomarkers of Lupus Nephritis

Long non‐coding RNAs in systemic lupus erythematosus: New insights into disease pathogenesis and diagnosis

Association Between Malat1 Rs4102217-Polymorphic Variant and Ishemic Atherothrombotic Stroke Development in People With Increased Body Mass Index

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