Prognostic analysis of postoperative clinically nonmetastatic renal cell carcinoma

Abstract

Objectives:To investigate the survival characteristics of postoperative nonmetastatic renal cell carcinoma (RCC) patients, and the predictive value of a prognostic model. Materials and Methods:We retrospectively evaluated data from 1202 postoperative nonmetastatic RCC patients who were treated between 1999 and 2012 at West China Hospital, Sichuan University (Chengdu, China). In addition, we also evaluated data relating to 53 205 cases acquired from the Surveillance, Epidemiology, and End Results (SEER) program. Survival analysis was performed on the cases, and subgroups, using the Kaplan-Meier and Cox regression methods. The concordance index of the Stage Size Grade Necrosis (SSIGN), Leibovich, and the UCLA integrated staging system, scores was determined to evaluate the accuracy of these outcome prediction models. Results:The 5-year overall survival rate for RCC cases in West China Hospital was 87.6%; this was higher than that observed for SEER cases. Survival analysis identified several factors that exerted significant influence over prognosis, including the time of surgery, Eastern Cooperative Oncology Group performance status, tumor stage, size, nuclear differentiation, pathological subtypes, along with necrotic and sarcomatoid differentiation. Moreover tumor stage, size, and nuclear grade were all identified as independent predictors for both our cases and those from the SEER program. Patient groups with advanced RCC, and poorly differentiated RCC subgroups, were both determined to have a poor prognosis. The SSIGN model yielded the best predictive value as a prognostic model, followed by the Leibovich, and UCLA integrated staging system; this was the case for our patients, and for sub-groups with a poor prognosis. Conclusion: The prognosis of RCC was mostly influenced by tumor stage, size, and nuclear differentiation. SSIGN may represent the most suitable prognostic model for the Chinese population. |SHAO et Al.

Novel Blood Indicators of Progression and Prognosis in Renal Cell Carcinoma: Red Cell Distribution Width-to-Lymphocyte Ratio and Albumin-to-Fibrinogen Ratio

“…RCC is a common urinary tract tumour with high incidence and poor prognosis, and it is usually diagnosed at an advanced stage, leading to poor treatment effect [ 1 – 3 ]. At present, RCC is mainly treated by surgery, and metastatic RCC can be supplemented by drug therapy, radiotherapy, and chemotherapy.…”

“…When RCC is diagnosed, about 30% of RCC patients are already in the advanced stage of the disease; therefore, the risk of postoperative recurrence is high [ 2 ]. Even in patients with local RCC, about one-third of patients after surgery may have cancer metastasis [ 3 ]. Despite advances in treatment, the prognosis of patients with advanced RCC is still not satisfactory.…”

An immune scores-based nomogram for predicting overall survival in patients with clear cell renal cell carcinoma

“…[ 39 ] Moreover, the results of this study show that tumor stage and grade could significantly affect the prognosis of ccRCC, which was in line with previous findings. [ 40 ] Tumors with later stages and grades tend to be more aggressive and have higher malignant potential. It has been reported in the literature that right-sided RCC was correlated with better survival than left-sided RCC, [ 41 ] which also supports our data.…”

Prospective evaluation of hematological parameters in preoperative renal cell cancer patients

“…Approximately one third of the patients diagnosed with RCC are found to be in the advanced stage [ 4 ]. In patients who are diagnosed with RCC at an early stage and operated on, the probability of metastasis during follow-up is 30 percent [ 5 ]. In RCC, the clinical parameters of the patient are as important as other parameters such as the stage, grade or histological type in determining the prognosis of the disease.…”