Prognosis of primary thyroid lymphoma: Demographic, clinical, and pathologic predictors of survival in 1,408 cases

Graff-Baker, Amanda; Roman, Sanziana A.; Thomas, Daniel C.; Udelsman, Robert; Sosa, Julie Ann

doi:10.1016/j.surg.2009.09.020

Cited by 171 publications

(199 citation statements)

References 20 publications

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“…Stage IE applies to disease exclusively in the thyroid; stage IIE refers to a lymphoma involving the thyroid and regional lymph nodes; stage IIIE designates disease involving the thyroid and lymph nodes on both sides of the diaphragm and/or the spleen; stage IVE applies to disseminated disease or multiorgan involvement. The majority (56%) of primary thyroid lymphomas are classified as stage IE, with only 11% classified as stage IVE (2). Primary thyroid lymphoma occurs disproportionately in women (about 70% of cases) and at …”

Section: Discussionmentioning

confidence: 99%

Concurrent Abdominal and Thyroid Lymphoma: A Case Report

Moore

Russell

Hoang

et al. 2018

AACE Clinical Case Reports

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Objective: Thyroid lymphoma constitutes a rare presentation of extranodal, diffuse, large B-cell lymphoma (DLBCL) and represents a small proportion of thyroid cancers. In this article, we present a case report of extranodal DLBCL presenting with simultaneous thyroid, abdominal, and retroperitoneal involvement. We also review the relevant epidemiologic literature and treatment modalities of thyroid lymphoma as well as providing a potential pathophysiologic mechanism.Methods: A literature search was conducted using the databases PubMed and Google Scholar for primary thyroid lymphoma and extranodal lymphoma involving the thyroid. Publications were selected based upon size of patient cohorts, treatment modalities investigated, quality of the data, as well as subsequent citation frequency. Articles most recently published, and therefore belonging to the post-rituximab era, were favored.

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Section: Discussionmentioning

confidence: 99%

Concurrent Abdominal and Thyroid Lymphoma: A Case Report

Moore

Russell

Hoang

et al. 2018

AACE Clinical Case Reports

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“…Links among auto-immune disease, chronic antigenic stimulation, and PTL have been demonstrated, and Hashimoto's thyroiditis represents the major risk factor (1,12,14) especially in a delay of 20-30 years after initial diagnosis (5,7,10,12) . Commonly, Hashimoto's thyroiditis is considering as a causal factor of primary thyroid MALT lymphoma, which itself may evolve into aggressive lymphoma (6,12,14,15) , by activating B-cells to secrete antibodies, conducting to hyperplasia or malignant transformation of lymphoid tissue (4) . Concerning our patients, we didn't notice any antecedent of Hashimot's thyroiditis, but we suggest a pre-existing chronic thyroiditis within 3 patients having a biologic hypothyroidism.…”

Section: Discussionmentioning

confidence: 99%

“…We describe different subtypes of NHL which are classified according to histological and immunological features, having different natural histories, and therapeutic responses (3,5) . Diffuse large B-cell lymphoma is the predominant subtype accounting 50% to 68% of PTL, followed by the extranodal marginal zone B-cell lymphoma of MALT which occurring in 23% of PTL, and less common mantle cell lymphoma, SLL, and follicular lymphoma (1,2,4,6,7) . The present paper aimed to evaluate the clinicopathological features and treatment outcomes of patients with primary thyroid lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Primary Thyroid Lymphoma : An Uncommon Etiology of Compressive Goiter

Meherzi¹,

Bellakhdher²,

Khaireddine³

et al. 2017

IAM

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Primary thyroid non-Hodgkin's lymphoma is a rare entity. It is defined as a lymphoma occurring in the thyroid gland with or without the involvement of regional lymph nodes. Diffuse large B-cell lymphoma is the predominant subtype, followed by the extranodal marginal zone B-cell lymphoma of MALT, mantle cell lymphoma, SLL, and follicular lymphoma. Hashimoto's thyroiditis is considering as a causal factor. Diffuse large B-cell lymphoma and mantle cell lymphoma are known by an aggressive course while MALT lymphoma and small lymphocytic lymphoma (SLL) are characterized by an indolent clinical course. The most common clinical presentation is an enlarging painless neck mass, growing rapidly and causing an obstruction of the upper airway. Differential diagnosis is an anaplastic carcinoma, squamous cell carcinoma, metastasis of unknown primary and thyroiditis. The sensitivity and the specificity of the FNAC can be increased if consolidated by the use of the flow cytometry, the immunohistochemistry (IHC) and PCR.Three modalities of treatment could be proposed: surgery, radiotherapy, and chemotherapy-dependent on the histologic subtype.

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“…Women are more commonly affected than men (2-8:1) [47,49,50]. Patients typically present in the sixth or seventh decade of life, with men often presenting at a younger age than women [49][50][51][52]. Most thyroid lymphomas are nonHodgkin's lymphomas (NHLs) of B-cell origin.…”

Section: Hashimoto's Thyroiditis and Thyroid Lymphomamentioning

confidence: 99%

Hashimoto’s Thyroiditis And Cancer: A Review

Salti

2017

int arch med

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Background: No consensus exists on the association betweenHashimoto's thyroiditis (HT) and cancer. To resolve this controversy, this review aimed to evaluate the relationship between the two conditions. Methods:Using pub-med database, we searched studies relevant to the topic focusing on the association between HT and papillary thyroid cancer (PTC), as well as the association between HT and primary thyroid lymphoma (PTL).Findings: Both HT and PTC are common worldwide, and the two conditions may be closely related. However, the relationship remains controversial. Some studies found that PTC coexisted with HT 2.8-fold more frequently, with variable prevalence ranging from 0.5 to 30%. In contrast to surgical and pathological series that suggested a positive correlation between the two diseases and even a cause-and-effect relationship, the other studies evaluating fine-needle aspirate specimens did not find a statistically significant correlation. On the other hand, the relationship between PTL and HT appears well established. Conclusion:The existing data provide inconsistent evidence favoring a causal relationship between HT and PTC. Prospective studies are needed to further elucidate the relationship. However patients with HT are at risk for PTL. Therefore careful observation and follow-up of HT patients is recommended.

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Prognosis of primary thyroid lymphoma: Demographic, clinical, and pathologic predictors of survival in 1,408 cases

Cited by 171 publications

References 20 publications

Concurrent Abdominal and Thyroid Lymphoma: A Case Report

Concurrent Abdominal and Thyroid Lymphoma: A Case Report

Primary Thyroid Lymphoma : An Uncommon Etiology of Compressive Goiter

Hashimoto’s Thyroiditis And Cancer: A Review

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