Lessons from arthritis and cell therapy in cancer patients point to therapy for severe disease

Although our data suggest that 1:1 FFP:RBC reduced coagulopathy, this did not translate into a survival benefit. Our findings indicate that the relationship between coagulopathy and mortality is more complex, and further clinical investigation is necessary before recommending routine 1:1 in the exsanguinating trauma patient.

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Nonoperative management of high-grade liver injuries can be safely accomplished. Mortality is low; however, complications in grade 4 and 5 injuries should be anticipated and may require a combination of operative and nonoperative management strategies.

Blunt vertebral artery injury is associated with complex cervical spine fractures involving subluxation, extension into the foramen transversarium, or upper C1 to C3 fractures. Routine screening should incorporate these findings to maximize yield while limiting the use of invasive procedures.

At least part of the difference in structure between the two commonly used preparations of nerve growth factor (NGF) proteins, /3 and 2.5S NGF, is explained by proteolytic modification of the C termini of their two peptide chains. In /3NGF isolated from the purified 7S NGF complex, the major species, ^NGF, has C-terminal arginine residues on both its t From the Departments of Genetics and Biochemistry and the