Prognosis of Elderly Japanese Patients Aged ≥80 Years Undergoing Hemodialysis

Hatakeyama, Shingo; Matsubara, Hiromi; Hamano, Itsuto; Kusaka, Ayumu; Narita, Takuma; Oikawa, Masaaki; Noro, Daisuke; Hagiwara, K.; Ishimura, Hirofumi; Yoneyama, Takahiro; Hashimoto, Yasuhiro; Koie, Takuya; Saitoh, Hisao; Funyu, Tomihisa; Οhyama, Chikara

doi:10.1155/2013/693514

Cited by 13 publications

(21 citation statements)

References 24 publications

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“…The survival of our patients beyond age 80 is similar or even better in comparison to other single-center studies of recent years [5,8,9]. Single-center data usually show better results than registry data, which represent all patients.…”

Section: Discussionsupporting

confidence: 65%

“…Duration and intensity of pre-dialysis nephrology care depend on referral practice and show considerable regional differences especially when concerning the elderly [1,5,7,8,11,12,13,14,15]. This is mainly due to the varying judgment of referring primary care physicians and non-nephrology specialists [16] who stress on the importance of local networks.…”

Section: Discussionmentioning

confidence: 99%

“…In the same year in Japan, 22% of all dialysis patients were 80 years or older, and the number seems to be on the increase every single year [5]. …”

Section: Introductionmentioning

confidence: 99%

“…Dialysis data, especially in the age group of octogenarians and nonagenarians, are rare [5,7,8]. Therefore, we analyzed the outcomes of our patients in this age group, particularly going by the influence of pre-ESRD care.…”

Section: Introductionmentioning

confidence: 99%

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Hemodialysis in Patients Over 80 Years

Leimbach¹,

Kron²,

Czerny³

et al. 2015

Nephron

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Background: In Germany, every fifth patient starting dialysis is now 80 years of age or older. The question that is currently relevant is not whether we have to treat patients who are older than 80. Rather the question now is how to treat this elderly group of patients. Methods: Single centre data of all dialysis patients aged over 80 were analyzed with regard to survival, social circumstances, vascular access, and pre-dialysis nephrology care. Results: Between 2001 and 2012, 76 patients over 80 years started chronic ambulatory hemodialysis treatment. One-year survival was 87%, 3-year survival 52%, 5-year survival 27% and 10-year survival 9%. Patients (n = 55) with more than 3 months of nephrological care prior to dialysis (3-161 months, median 31 months) survived significantly longer then patients (n = 21) having had less than 3 months contact with nephrologists. On 31st December 2012 there were 38 patients aged ≥80 (median age 84, 80-95 years) in the chronic hemodialysis program accounting for 19% of all dialysis patients of this center. Thirty patients (79%) had been in long-term nephrological care prior to dialysis initiation (3-161 months, median 45 months). Thirty one patients (82%) started the first dialysis treatment with a functioning shunt access. Conclusion: Long-term pre-dialysis nephrology care is of most importance for successful dialysis treatment in the elderly, especially in octogenarians and nonagenarians. It enables the early establishment of functioning vascular access and careful scheduling of first dialysis treatment and increases survival. The long-term use of catheters can be avoided in almost all patients above the age of 80.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

“…In the same year in Japan, 22% of all dialysis patients were 80 years or older, and the number seems to be on the increase every single year [5]. …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hemodialysis in Patients Over 80 Years

Leimbach¹,

Kron²,

Czerny³

et al. 2015

Nephron

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show abstract

“…The incidence and prevalence of dialysis among the elderly population are found to be growing more rapidly when compared to its incidence and prevalence among the younger age groups [1][2][3][4] . An increasing number of patients cross the age of 80 when they have to be started on dialysis [4,5] .…”

Section: Introductionmentioning

confidence: 99%

Comorbidities, Hospitalization, and Living Status of Dialysis Patients Over 80 Years

Leimbach

Kron

Pommer³

et al. 2016

Blood Purif

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Background: An increasing number of patients start dialysis when they are over 80 years or reaches their eighties on dialysis. The burden of dialysis can affect their quality of life. Methods: Clinical and social data of all patients aged 80 years or older who underwent chronic dialysis treatment in a single center were analyzed. Results: Fifty-nine patients aged between 80 and 92 years were in chronic dialysis treatment on December 31, 2015. Median time on dialysis was 57 months (3-330 months). Hospitalization rate and days in hospital were lower in this group than in younger patients (1.05 vs. 1.34 hospitalizations; 8.3 vs. 9.0 hospital days per patient and year) despite the presence of many comorbidities. The median patency of the currently used arteriovenous shunt was 70 months (6-194 months). Social status was comparable with the population of the rest of the same average age range. Conclusion: Dialysis patients aged ≥80 years have a satisfactory quality of life with no more complications than younger patients.

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The impact of muscle mass loss and deteriorating physical function on prognosis in patients receiving hemodialysis

Kitamura

Takazono

Yamaguchi

et al. 2021

Sci Rep

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Muscle mass loss and worsening physical function are crucial issues in patients receiving hemodialysis (HD). However, few studies have investigated the association between temporal changes in muscle mass and physical function in a large number of HD patients. We examined 286 patients receiving HD (males, 58%; age, 66.8 ± 13.0 years) at a single center, and calculated the percent changes in psoas muscle mass index (%PMI) using computed tomography over two screenings, once per year (July 2011–June 2013). Physical function was evaluated using the Eastern Cooperative Oncology Group Performance Status (ECOG-PS) (range 0–4). The observation period was from July 2012 to June 2021. The median %PMI was -9.5%, and those with the lowest quartile of %PMI (< −20.5%) showed a significantly poor prognosis compared with other patients (p < 0.001). Multivariable logistic regression analysis revealed that these patients tended to have decreased physical function (ECOG-PS 2–4) [odds ratio (OR): 2.46, p < 0.001] and albumin levels (OR: 0.22, p = 0.007). Multiple-factor-adjusted Cox regression analyses showed that %PMI (hazard ratio: 0.99, p = 0.004) and each ECOG-PS stage (1–4 vs. 0) (p < 0.01) were associated with mortality. Augmenting physical activities in daily life and serum albumin levels should be considered to maintain muscle mass and improve the prognosis of patients receiving HD.

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Prognosis of Elderly Japanese Patients Aged ≥80 Years Undergoing Hemodialysis

Cited by 13 publications

References 24 publications

Hemodialysis in Patients Over 80 Years

Hemodialysis in Patients Over 80 Years

Comorbidities, Hospitalization, and Living Status of Dialysis Patients Over 80 Years

The impact of muscle mass loss and deteriorating physical function on prognosis in patients receiving hemodialysis

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