“…The metabolic changes of normal pregnancy are characterized by a rise of plasma FFA (Kalkhoff et al, 1964), the development of insulin resistance (Burt, 1960), and an increased insulin response to glucose (Spellacy & Goetz, 1963;Spellacy et al, 1965). Established diabetics usually require more insulin during pregnancy, and diabetes may first become manifest during pregnancy in individuals who are presumably genetically predisposed (Hagbard & Svanborg, 1960). Although the hormonal changes of pregnancy are very complex it seems likely that these changes are, at least in part, the result of HCS secretion.…”