Human Chorionic Somatomamotraophin and Its Clinical Significance

Hartog, M.

doi:10.1111/j.1365-2265.1972.tb00392.x

Cited by 10 publications

(3 citation statements)

References 80 publications

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“…A number of previous publications indicate of human placental lactogen (HPL) levels in that the plasma levels of HPL in normal maternal blood may be useful in the supervision pregnancy show no significant variation during of high risk pregnancies (Hartog, 1972; Genaz-a 24-hour period and that they are unaffected by zani et al, 1972), but the value of the test exercise, meals, maternal glucose and insulin is still controversial. levels (Spellacy et al, 1966; Grumbach et af., In the last few years a number of methods for 1968 ;Tyson et al, 1971).…”

Section: Many Reports Indicate That Serial Determinationsmentioning

confidence: 99%

Variations in Maternal Plasma Levels of Human Placental Lactogen (Hpl) in Normal Pregnancy and Labour

Lindberg

Nilsson

1973

BJOG

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Summary Plasma levels of human placental lactogen (HPL) in normal pregnancy from the 22nd week until delivery were measured with a rapid radioimmunoassay. The HPL concentration in plasma rose steadily up to the 37th week and thereafter gradually decreased until delivery. Individual women followed during the latter part of pregnancy showed a characteristic pattern with very small deviations from their original relative level within the normal range. Significant fluctuations in HPL levels were noted during a 24‐hour period of sampling and during shorter periods. No systematic circadian variation was observed. The variations showed no clear relation to sleep, meals or light exercise. During spontaneous and induced labour significant fluctuations in HPL concentrations occurred but these were of the same magnitude as those during the latter part of normal pregnancy; no correlation between HPL levels and uterine contraction and relaxation was found. Strenuous physical exercise during the last month of pregnancy sufficient to affect the fetal heart rate did not influence the HPL levels.

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Section: Many Reports Indicate That Serial Determinationsmentioning

confidence: 99%

Variations in Maternal Plasma Levels of Human Placental Lactogen (Hpl) in Normal Pregnancy and Labour

Lindberg

Nilsson

1973

BJOG

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“…The growth hormone and prolactin-like activities attributed to HPL (Grumbach, Kaplan, Sciarra & Burr, 1968;Frantz, Kleinberg & Noel, 1972) may be important in modulating biochemical processes in pregnancy such as glucose homeostasis, luteolysis, protein and fat metabolism (for reviews see Grumbach et al 1968;Brody, 1969;Hartog, 1972). The prolactin-like activity of HPL has been demonstrated by the proliferation of the pigeon crop sac (Li, 1970) and by its effect on mouse (Frantz & Kleinberg, 1970) and rabbit (Forsyth & Myres, 1971) cultured lobulo-alveolar mammary tissue.…”

Section: Introductionmentioning

confidence: 99%

Uptake of 125i-Labelled Human Placental Lactogen and Human Placental Lactogen by the Tissues of Normal and Lactating Rats

Reddy¹,

Watkins²

1975

Journal of Endocrinology

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The rate of clearance from the circulation and uptake into tissues of radioactive label was studied after i.v. injection of 125-I-labelled human placental lactogen (HPL) into rats at various stages of pregnancy. The half-life was obtained for the disappearance of the trichloroacetic acid-precipitable material from the plasma. The half-life, t1/2(S), calculated over the first 5 min after injection of the hormone was 5.4 equals or minus 1.1 (S.D.) min, while a half-life, t1/2(L), of 27.9 equals or minus 2.3 min was obtained from the decay period of 15-35 min. In the non-pregnant and pregnant rat the highest ratio of the radioactivity in an organ to that in the blood was 12-14:1 in the kidney. That the kidney is mainly involved in the uptake of exogenous HPL is further confirmed by the application of the histochemical immunoperoxidase technique. Human placental lactogen was localized in the cells of the proximal tubules of the cortex and to a lesser extent in the tubular lumen and the tubules of the medulla region. UPTAKE OF HPL in vivo occurs in the mammary gland tissue of the post-partum rat and reaches a maximum uptake between 15 and 30 min after injection of the hormone. Furthermore, specific uptake of HPL was observed on the alveolar cell membranes after the incubation of paraffin-embedded sections of formalin-fixed mammary gland and subsequent treatment by the peroxidase-labelled antibody method. These findings support the work of others who have demonstrated the presence of specific membrane receptors in the mammary gland for hormones with prolactin-like activity.

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“…Our observation that sebum production is in creased during pregnancy, at a time when oestrogens are being produced in quantilies of the order of 200 mg per day ( 10), suggcsts that a powerful sebotrophic stimulus is produced during pregnancy. This sebotrophic factor is unlikely to be chorionic somatomammotrophin ( HCS, formerly called pla cental lactogen) since serum HCS levels are usually eleva1ed in twin pregnancies (11 ), whereas we found the mean SER 10 be slightly depressed in women with twins, compared with lhat in women with a single foelus.…”

Section: Discussionmentioning

confidence: 54%

The sebotrophic effect of pregnancy

Burton,

Shuster,

Cartlidge

1975

Acta Derm Venereol

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The sebum excretion rate (SER) in forehead skin was measured in late pregnancy and 8-20 weeks after delivery in 43 women. There was considerable individual variation but the mean SER during pregnancy was significantly higher than in a control group of non-pregnant women and it showed a large and significant decrease to the control level after delivery. This suggests that a powerful sebotrophic hormone is secreted during pregnancy. The mean SER during pregnancy in women with twins or triplets was no greater than the SER in women with a single foetus. This suggests that the sebotrophic factor of pregnancy is unlikely to be of placental origin, and is in keeping with the idea that the sebotrophic factor may come from the pituitary.

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Human Chorionic Somatomamotraophin and Its Clinical Significance

Cited by 10 publications

References 80 publications

Variations in Maternal Plasma Levels of Human Placental Lactogen (Hpl) in Normal Pregnancy and Labour

Variations in Maternal Plasma Levels of Human Placental Lactogen (Hpl) in Normal Pregnancy and Labour

Uptake of 125i-Labelled Human Placental Lactogen and Human Placental Lactogen by the Tissues of Normal and Lactating Rats

The sebotrophic effect of pregnancy

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