Prognosis of cerebellar astrocytomas in children

Villarejo, F.; Diego, Jose Maria Belinchón de; Riva, Á. Gómez de la

doi:10.1007/s00381-007-0449-8

Cited by 29 publications

(15 citation statements)

References 27 publications

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“…Ten-year progression-free survival rates range from 81% to 93% [29][30][31]. In our series, surgery alone was largely successful in disease control.…”

Section: Discussionmentioning

confidence: 82%

Outcome of children with low-grade cerebellar astrocytoma: long-term complications and quality of life

et al. 2008

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Objects To study the long-term outcome of surgically treated low-grade cerebellar astrocytomas in children. Materials and methods We followed 31 consecutive patients under 16 years of age who were diagnosed between 1980 and 2005 in a single institution. In 21 of 31 survivors (median follow-up time 7.9 years; range 5.6-27.4 years) who agreed to participate, tumor control, neurological and cognitive complications, and their impact on behavioral and emotional adjustment and health-related quality of life (HRQoL) were comprehensively assessed qualitatively and quantitatively. Results Neurological sequelae were found in 43%. However, age-appropriate ability to perform daily life activities was normal in all patients. Remarkably, cognitive deficits leading to significant school problems occurred in 19% and behavioral and emotional adjustment disturbances in 27%. In comparison with healthy controls, the survivors rated their HRQoL similarly or even higher. Conclusion Childhood low-grade cerebellar astrocytomas have an excellent cure rate by tumor surgery alone. When compared with other pediatric brain tumors, the risk of neurological, cognitive, emotional, and behavioral complications is relatively small. HRQoL is similar to that of healthy controls.

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“…Ten-year progression-free survival rates range from 81% to 93% [29][30][31]. In our series, surgery alone was largely successful in disease control.…”

Section: Discussionmentioning

confidence: 82%

Outcome of children with low-grade cerebellar astrocytoma: long-term complications and quality of life

et al. 2008

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“…The prognosis depends particularly on the completeness of resection and tumor characteristics such as location, gross structure, and size. Complete resection, hemispheric location, small size, and presence of cysts are favorable prognostic factors (7).…”

Section: Astrocytomamentioning

confidence: 99%

Neuroimaging of pediatric posterior fossa tumors including review of the literature

Poretti

Meoded

Huisman

2011

Magnetic Resonance Imaging

176

148

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Conventional, anatomical MRI is an essential tool for diagnosis and evaluation of location, quality, and extent of posterior fossa tumors, but offers limited information regarding tumor grade and type. Advanced MRI techniques such as diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) may improve the specific diagnosis of brain tumors in the posterior fossa in children. In this review the conventional neuroimaging findings, as well as the DWI, and DTI characteristics of common pediatric posterior fossa tumors are discussed and summarized.

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“…[6] Vilarejo et al ., concluded from their study that completeness of excision and tumor characteristics affected prognosis. [24] Pencalet et al ., found that brain stem involvement was a very significant factor, as it had a direct bearing on neurological outcome and length of survival as well as an indirect bearing on recurrence as these children were more likely to have an incomplete excision of tumor. [13] Kurwale et al ., studying recurrences in PA, found that radiology, histology and proliferative indices did not offer any prognostic information.…”

Section: Cerebellar Astrocytomasmentioning

confidence: 99%

Management of posterior fossa gliomas in children

Sridhar

Venkatprasanna

2011

J Pediatr Neurosci

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Brain tumours form the most common type of solid tumour in children and more that 50% of these are infratentorial. Cerebellar astrocytomas and brain stem gliomas are the commonest posterior fossa glial tumours in children. Cerebellar astrocytomas represent up to 10% of all primary brain tumours and up to 25% of posterior fossa tumors in children, with Low grade gliomas forming the commonest of the cerebellar gliomas. They commonly present with symptoms and signs of raised intracranial pressure due to obstructive hydrocephalus. Radiologically they may be solid or cystic with or without a mural nodule. Surgical excision is the mainstay of treatment and forms the most consistent factor influencing progression free and long term survival. While majority of the tumours are pilocytic astrocytomas, they may also be fibrillary astrocytomas or even high grade tumours. Tumour histology does not appear to be an independent factor in the prognosis of these children, and therefore no palliative treatment after surgery is advocated. Brain stem gliomas account for approximately 10% of all pediatric brain tumours. Cranial nerve signs, ataxia and cerebellar signs with or without symptoms and signs of raised intracranial pressure are classically described symptoms and signs. Radiographic findings and clinical correlates can be used to categorize brain stem tumours into four types: diffuse, focal, exophytic and cervicomedullary. Histologically most brain stem gliomas are fibrillary astrocytomas. Diffuse brain stem gliomas are the most commonly seen tumour in the brain stem. These lesions are malignant high grade fibrillary astrocytomas. Focal tumours of the brain stem are demarcated lesions generally less than 2 cms in size, without associated edema. Most commonly seen in the midbrain or medulla, they form a heterogeneous pathological group, showing indolent growth except when the lesion is a PNET. Dorsally exophytic tumours lie in the fourth ventricle, while cervicomedullary lesions are similar to spinal intramedullary tumours. Expanding lesions are the only lesions amenable for excision while infiltrative and ventral lesions are not.

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Prognosis of cerebellar astrocytomas in children

Cited by 29 publications

References 27 publications

Outcome of children with low-grade cerebellar astrocytoma: long-term complications and quality of life

Outcome of children with low-grade cerebellar astrocytoma: long-term complications and quality of life

Neuroimaging of pediatric posterior fossa tumors including review of the literature

Management of posterior fossa gliomas in children

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